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Serum glycated albumin levels are influenced by smoking status, independent of plasma glucose levels.
Acta Diabetol. 2009 Jun; 46(2):141-4.AD

Abstract

Serum glycated albumin (GA) is the clinical markers reflecting recent plasma glucose levels. We have previously clarified that serum GA levels are low for obesity and chronic inflammation is involved in the obesity-associated decrease in GA levels through acceleration of albumin catabolism. The present study investigated whether smoking, which is a representative factor that increases CRP, affects serum GA levels. One hundred and three male subjects with normal glucose tolerance (70 nonsmokers, 33 smokers) were enrolled in this study. Smokers and nonsmokers displayed no significant differences in fasting plasma glucose (FPG), oral glucose tolerance test 2-h glucose and HbA(1C). CRP levels were significantly higher in smokers than in nonsmokers (P < 0.05). Serum GA levels were significantly lower in smokers than in nonsmokers (P < 0.05). Stepwise multivariate regression analysis identified FPG and age as positively associated, and BMI and smoking as negatively associated with serum GA levels. In conclusion, serum GA levels were significantly lower in smokers than in nonsmokers. Smoking was identified as a significant negative explanatory variable for serum GA levels. These findings suggest that the inflammation-induced acceleration of albumin metabolism may be involved in the mechanism by which smoking is associated with serum GA levels.

Authors+Show Affiliations

Department of Internal Medicine, Kinki Central Hospital, Kuruma-zuka 3-1, Itami, Hyogo, 664-8533, Japan. koga_m@kich.itami.hyogo.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18839052

Citation

Koga, Masafumi, et al. "Serum Glycated Albumin Levels Are Influenced By Smoking Status, Independent of Plasma Glucose Levels." Acta Diabetologica, vol. 46, no. 2, 2009, pp. 141-4.
Koga M, Saito H, Mukai M, et al. Serum glycated albumin levels are influenced by smoking status, independent of plasma glucose levels. Acta Diabetol. 2009;46(2):141-4.
Koga, M., Saito, H., Mukai, M., Otsuki, M., & Kasayama, S. (2009). Serum glycated albumin levels are influenced by smoking status, independent of plasma glucose levels. Acta Diabetologica, 46(2), 141-4. https://doi.org/10.1007/s00592-008-0072-5
Koga M, et al. Serum Glycated Albumin Levels Are Influenced By Smoking Status, Independent of Plasma Glucose Levels. Acta Diabetol. 2009;46(2):141-4. PubMed PMID: 18839052.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum glycated albumin levels are influenced by smoking status, independent of plasma glucose levels. AU - Koga,Masafumi, AU - Saito,Hiroshi, AU - Mukai,Mikio, AU - Otsuki,Michio, AU - Kasayama,Soji, Y1 - 2008/10/07/ PY - 2008/05/16/received PY - 2008/09/12/accepted PY - 2008/10/8/pubmed PY - 2009/7/30/medline PY - 2008/10/8/entrez SP - 141 EP - 4 JF - Acta diabetologica JO - Acta Diabetol VL - 46 IS - 2 N2 - Serum glycated albumin (GA) is the clinical markers reflecting recent plasma glucose levels. We have previously clarified that serum GA levels are low for obesity and chronic inflammation is involved in the obesity-associated decrease in GA levels through acceleration of albumin catabolism. The present study investigated whether smoking, which is a representative factor that increases CRP, affects serum GA levels. One hundred and three male subjects with normal glucose tolerance (70 nonsmokers, 33 smokers) were enrolled in this study. Smokers and nonsmokers displayed no significant differences in fasting plasma glucose (FPG), oral glucose tolerance test 2-h glucose and HbA(1C). CRP levels were significantly higher in smokers than in nonsmokers (P < 0.05). Serum GA levels were significantly lower in smokers than in nonsmokers (P < 0.05). Stepwise multivariate regression analysis identified FPG and age as positively associated, and BMI and smoking as negatively associated with serum GA levels. In conclusion, serum GA levels were significantly lower in smokers than in nonsmokers. Smoking was identified as a significant negative explanatory variable for serum GA levels. These findings suggest that the inflammation-induced acceleration of albumin metabolism may be involved in the mechanism by which smoking is associated with serum GA levels. SN - 1432-5233 UR - https://www.unboundmedicine.com/medline/citation/18839052/Serum_glycated_albumin_levels_are_influenced_by_smoking_status_independent_of_plasma_glucose_levels_ L2 - https://dx.doi.org/10.1007/s00592-008-0072-5 DB - PRIME DP - Unbound Medicine ER -