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[Neuraminidase inhibitors in prophylaxis and treatment of influenza].
Pol Merkur Lekarski. 2008 Jul; 25(145):67-73.PM

Abstract

Influenza is an acute infectious disease which may cause spectacular health, social and economic effects. Influenza may be prevented and treated in a sufficient way. The paper presents general rules of usage of current antiviral drugs--neuraminidase inhibitors--in prophylaxis and treatment of seasonal, avian and pandemic influenza. The paper describes mechanism of action of neuraminidase inhibitors (oseltamivir and zanamivir), their main pharmacokinetic features, dosing and side effects. There was emphasized the necessity of the early introduction of treatment with neuraminidase inhibitors (36-48 hours after first symptoms) and the short duration of treatment (5 days). It is also discussed the role of neuraminidase inhibitors in the clinical management of avian influenza (H5N1) and their role in fighting with a pandemic disease.

Authors+Show Affiliations

Department of Family Medicine, Medical University of Warsaw, Poland. anitsch@amwaw.edu.plNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

18839619

Citation

Nitsch-Osuch, Aneta, et al. "[Neuraminidase Inhibitors in Prophylaxis and Treatment of Influenza]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 25, no. 145, 2008, pp. 67-73.
Nitsch-Osuch A, Brydak LB, Wardyn AK. [Neuraminidase inhibitors in prophylaxis and treatment of influenza]. Pol Merkur Lekarski. 2008;25(145):67-73.
Nitsch-Osuch, A., Brydak, L. B., & Wardyn, A. K. (2008). [Neuraminidase inhibitors in prophylaxis and treatment of influenza]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 25(145), 67-73.
Nitsch-Osuch A, Brydak LB, Wardyn AK. [Neuraminidase Inhibitors in Prophylaxis and Treatment of Influenza]. Pol Merkur Lekarski. 2008;25(145):67-73. PubMed PMID: 18839619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Neuraminidase inhibitors in prophylaxis and treatment of influenza]. AU - Nitsch-Osuch,Aneta, AU - Brydak,Lidia B, AU - Wardyn,Andrzej K, PY - 2008/10/9/pubmed PY - 2008/12/17/medline PY - 2008/10/9/entrez SP - 67 EP - 73 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol. Merkur. Lekarski VL - 25 IS - 145 N2 - Influenza is an acute infectious disease which may cause spectacular health, social and economic effects. Influenza may be prevented and treated in a sufficient way. The paper presents general rules of usage of current antiviral drugs--neuraminidase inhibitors--in prophylaxis and treatment of seasonal, avian and pandemic influenza. The paper describes mechanism of action of neuraminidase inhibitors (oseltamivir and zanamivir), their main pharmacokinetic features, dosing and side effects. There was emphasized the necessity of the early introduction of treatment with neuraminidase inhibitors (36-48 hours after first symptoms) and the short duration of treatment (5 days). It is also discussed the role of neuraminidase inhibitors in the clinical management of avian influenza (H5N1) and their role in fighting with a pandemic disease. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/18839619/[Neuraminidase_inhibitors_in_prophylaxis_and_treatment_of_influenza]_ L2 - https://medlineplus.gov/flu.html DB - PRIME DP - Unbound Medicine ER -