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Circulating malondialdehyde-modified low-density lipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men.
Clin Chim Acta. 2009 Jan; 399(1-2):74-8.CC

Abstract

BACKGROUND

Despite the importance of oxidized LDL and small LDL particles as atherogenic lipoproteins, the relationship between oxidized LDL and the distributions of size subclasses of lipoproteins is not fully proved. We investigated the relationship of circulating malondialdehyde-modified (MDA)-LDL, an oxidized form of LDL, and lipoprotein subclasses in healthy men.

METHODS

The study group consisted of a total of 170 healthy Japanese men (55+/-9 y). Plasma cholesterol concentrations in major lipoproteins and their subclasses were determined by HPLC with gel permeation columns.

RESULTS

In univariate analysis, body mass index, waist circumference, blood pressure, white blood cell count, C-reactive protein, uric acid, fasting insulin, HOMA-IR, total cholesterol, triglycerides, each VLDL subclass cholesterol, each LDL subclass cholesterol, small HDL cholesterol, and very small HDL cholesterol were positively correlated with MDA-LDL, whereas adiponectin and large HDL cholesterol were inversely correlated with MDA-LDL. In stepwise multiple regression analysis, very small LDL cholesterol, medium VLDL cholesterol, very small HDL cholesterol, small HDL cholesterol, and systolic blood pressure were identified as independent determinants of MDA-LDL (R(2)=0.718, p<0.0001).

CONCLUSIONS

Circulating MDA-LDL concentrations are strongly associated with very small LDL cholesterol concentrations in healthy men. HDL size heterogeneity has a biphasic effect on MDA-LDL.

Authors+Show Affiliations

Department of Cardiology, Chunichi Hospital, Nagoya, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18840422

Citation

Takahashi, Ryotaro, et al. "Circulating Malondialdehyde-modified Low-density Lipoprotein Is Strongly Associated With Very Small Low-density Lipoprotein Cholesterol Concentrations in Healthy Men." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 399, no. 1-2, 2009, pp. 74-8.
Takahashi R, Imamura A, Yoshikane M, et al. Circulating malondialdehyde-modified low-density lipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men. Clin Chim Acta. 2009;399(1-2):74-8.
Takahashi, R., Imamura, A., Yoshikane, M., Suzuki, M., Cheng, X. W., Numaguchi, Y., Ikeda, N., Murohara, T., & Okumura, K. (2009). Circulating malondialdehyde-modified low-density lipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men. Clinica Chimica Acta; International Journal of Clinical Chemistry, 399(1-2), 74-8. https://doi.org/10.1016/j.cca.2008.09.015
Takahashi R, et al. Circulating Malondialdehyde-modified Low-density Lipoprotein Is Strongly Associated With Very Small Low-density Lipoprotein Cholesterol Concentrations in Healthy Men. Clin Chim Acta. 2009;399(1-2):74-8. PubMed PMID: 18840422.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating malondialdehyde-modified low-density lipoprotein is strongly associated with very small low-density lipoprotein cholesterol concentrations in healthy men. AU - Takahashi,Ryotaro, AU - Imamura,Akiko, AU - Yoshikane,Mari, AU - Suzuki,Masayuki, AU - Cheng,Xian Wu, AU - Numaguchi,Yasushi, AU - Ikeda,Nobuo, AU - Murohara,Toyoaki, AU - Okumura,Kenji, Y1 - 2008/09/21/ PY - 2008/07/13/received PY - 2008/09/14/revised PY - 2008/09/15/accepted PY - 2008/10/9/pubmed PY - 2009/9/25/medline PY - 2008/10/9/entrez SP - 74 EP - 8 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 399 IS - 1-2 N2 - BACKGROUND: Despite the importance of oxidized LDL and small LDL particles as atherogenic lipoproteins, the relationship between oxidized LDL and the distributions of size subclasses of lipoproteins is not fully proved. We investigated the relationship of circulating malondialdehyde-modified (MDA)-LDL, an oxidized form of LDL, and lipoprotein subclasses in healthy men. METHODS: The study group consisted of a total of 170 healthy Japanese men (55+/-9 y). Plasma cholesterol concentrations in major lipoproteins and their subclasses were determined by HPLC with gel permeation columns. RESULTS: In univariate analysis, body mass index, waist circumference, blood pressure, white blood cell count, C-reactive protein, uric acid, fasting insulin, HOMA-IR, total cholesterol, triglycerides, each VLDL subclass cholesterol, each LDL subclass cholesterol, small HDL cholesterol, and very small HDL cholesterol were positively correlated with MDA-LDL, whereas adiponectin and large HDL cholesterol were inversely correlated with MDA-LDL. In stepwise multiple regression analysis, very small LDL cholesterol, medium VLDL cholesterol, very small HDL cholesterol, small HDL cholesterol, and systolic blood pressure were identified as independent determinants of MDA-LDL (R(2)=0.718, p<0.0001). CONCLUSIONS: Circulating MDA-LDL concentrations are strongly associated with very small LDL cholesterol concentrations in healthy men. HDL size heterogeneity has a biphasic effect on MDA-LDL. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/18840422/Circulating_malondialdehyde_modified_low_density_lipoprotein_is_strongly_associated_with_very_small_low_density_lipoprotein_cholesterol_concentrations_in_healthy_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(08)00468-3 DB - PRIME DP - Unbound Medicine ER -