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C-reactive protein: vascular risk marker in elderly patients with mental illness.

Abstract

BACKGROUND

There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics.

METHODS

In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease.

RESULTS

Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment.

CONCLUSION

The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden.

    ,

    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Aging
    Alzheimer Disease
    C-Reactive Protein
    Cerebrovascular Disorders
    Cognition Disorders
    Cystatin C
    Depression
    Female
    Homocysteine
    Humans
    Male
    Mental Disorders
    Middle Aged
    Risk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    18841009

    Citation

    Nilsson, Karin, et al. "C-reactive Protein: Vascular Risk Marker in Elderly Patients With Mental Illness." Dementia and Geriatric Cognitive Disorders, vol. 26, no. 3, 2008, pp. 251-6.
    Nilsson K, Gustafson L, Hultberg B. C-reactive protein: vascular risk marker in elderly patients with mental illness. Dement Geriatr Cogn Disord. 2008;26(3):251-6.
    Nilsson, K., Gustafson, L., & Hultberg, B. (2008). C-reactive protein: vascular risk marker in elderly patients with mental illness. Dementia and Geriatric Cognitive Disorders, 26(3), pp. 251-6. doi:10.1159/000160957.
    Nilsson K, Gustafson L, Hultberg B. C-reactive Protein: Vascular Risk Marker in Elderly Patients With Mental Illness. Dement Geriatr Cogn Disord. 2008;26(3):251-6. PubMed PMID: 18841009.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - C-reactive protein: vascular risk marker in elderly patients with mental illness. AU - Nilsson,Karin, AU - Gustafson,Lars, AU - Hultberg,Björn, Y1 - 2008/10/08/ PY - 2008/07/04/accepted PY - 2008/10/9/pubmed PY - 2009/1/9/medline PY - 2008/10/9/entrez SP - 251 EP - 6 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 26 IS - 3 N2 - BACKGROUND: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics. METHODS: In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease. RESULTS: Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment. CONCLUSION: The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/18841009/C_reactive_protein:_vascular_risk_marker_in_elderly_patients_with_mental_illness_ L2 - https://www.karger.com?DOI=10.1159/000160957 DB - PRIME DP - Unbound Medicine ER -