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C-reactive protein: vascular risk marker in elderly patients with mental illness.
Dement Geriatr Cogn Disord 2008; 26(3):251-6DG

Abstract

BACKGROUND

There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics.

METHODS

In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease.

RESULTS

Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment.

CONCLUSION

The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP.

Authors+Show Affiliations

Department of Psychogeriatrics, Clinical Science, Lund University Hospital, Lund, Sweden.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18841009

Citation

Nilsson, Karin, et al. "C-reactive Protein: Vascular Risk Marker in Elderly Patients With Mental Illness." Dementia and Geriatric Cognitive Disorders, vol. 26, no. 3, 2008, pp. 251-6.
Nilsson K, Gustafson L, Hultberg B. C-reactive protein: vascular risk marker in elderly patients with mental illness. Dement Geriatr Cogn Disord. 2008;26(3):251-6.
Nilsson, K., Gustafson, L., & Hultberg, B. (2008). C-reactive protein: vascular risk marker in elderly patients with mental illness. Dementia and Geriatric Cognitive Disorders, 26(3), pp. 251-6. doi:10.1159/000160957.
Nilsson K, Gustafson L, Hultberg B. C-reactive Protein: Vascular Risk Marker in Elderly Patients With Mental Illness. Dement Geriatr Cogn Disord. 2008;26(3):251-6. PubMed PMID: 18841009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - C-reactive protein: vascular risk marker in elderly patients with mental illness. AU - Nilsson,Karin, AU - Gustafson,Lars, AU - Hultberg,Björn, Y1 - 2008/10/08/ PY - 2008/07/04/accepted PY - 2008/10/9/pubmed PY - 2009/1/9/medline PY - 2008/10/9/entrez SP - 251 EP - 6 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 26 IS - 3 N2 - BACKGROUND: There is increasing evidence that vascular disease contributes to cognitive impairment and dementia. Clarification of the role of vascular risk factors in dementia is important because most are modifiable, in contrast to other risk factors such as age and genetics. METHODS: In 428 patients with mental illness we have investigated the relation of vascular disease to diagnoses, and a biochemical parameter, C-reactive protein (CRP), which is associated with inflammation and vascular disease. RESULTS: Patients with vascular disease showed higher CRP levels than patients without vascular disease. Furthermore, patients with Alzheimer's disease showed lower CRP levels than patients with vascular dementia, mild cognitive impairment or depression. There is no obvious reason for this finding, since it could not be attributed to drug treatment. CONCLUSION: The findings indicate that the control of conventional vascular risk factors and therapy could be guided by the level of CRP. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/18841009/C_reactive_protein:_vascular_risk_marker_in_elderly_patients_with_mental_illness_ L2 - https://www.karger.com?DOI=10.1159/000160957 DB - PRIME DP - Unbound Medicine ER -