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Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia.
Dement Geriatr Cogn Disord. 2008; 26(4):323-9.DG

Abstract

BACKGROUND/AIMS

Alzheimer's disease (AD) is preceded by prodromal states. To determine the neuroanatomical basis for the relationship among such states, we assessed surface conformations of the hippocampus in AD, mild cognitive impairment (MCI) and subjective memory impairment (SMI).

METHODS

Hippocampal surfaces were reconstructed three-dimensionally via large-deformation high-dimensional MRI brain mapping in 14 SMI, 15 MCI, 12 AD and 13 controls. The surfaces were divided a priori into lateral, superior and inferior-medial zones, which approximated the CA1, combined CA2, CA3, CA4 subfields and the subiculum, respectively.

RESULTS

Group differences reached statistical significance in the lateral zone (F = 3.2, d.f. = 3, p = 0.033) and inferior-medial zone (F = 2.8, d.f. = 3, p = 0.049) subfields. The groups differed in total hippocampal volume only at the trend level (F = 2.5, d.f. = 3, p = 0.071). Surface deformation maps revealed similar patterns in SMI, MCI and AD subjects, but quantitative differences were significant only when comparing MCI and AD with control subjects.

CONCLUSIONS

Hippocampal surface deformation in the CA1 subfield was most pronounced in AD, less so in MCI and minor in SMI subjects. These results suggest that hippocampus degeneration develops gradually in AD, and may be observable long before dementia is apparent.

Authors+Show Affiliations

Department of Psychiatry, University of Cologne, Cologne, Germany. ralf.tepest@uk-koeln.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18841017

Citation

Tepest, Ralf, et al. "Hippocampal Surface Analysis in Subjective Memory Impairment, Mild Cognitive Impairment and Alzheimer's Dementia." Dementia and Geriatric Cognitive Disorders, vol. 26, no. 4, 2008, pp. 323-9.
Tepest R, Wang L, Csernansky JG, et al. Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia. Dement Geriatr Cogn Disord. 2008;26(4):323-9.
Tepest, R., Wang, L., Csernansky, J. G., Neubert, P., Heun, R., Scheef, L., & Jessen, F. (2008). Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia. Dementia and Geriatric Cognitive Disorders, 26(4), 323-9. https://doi.org/10.1159/000161057
Tepest R, et al. Hippocampal Surface Analysis in Subjective Memory Impairment, Mild Cognitive Impairment and Alzheimer's Dementia. Dement Geriatr Cogn Disord. 2008;26(4):323-9. PubMed PMID: 18841017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hippocampal surface analysis in subjective memory impairment, mild cognitive impairment and Alzheimer's dementia. AU - Tepest,Ralf, AU - Wang,Lei, AU - Csernansky,John G, AU - Neubert,Philip, AU - Heun,Reinhard, AU - Scheef,Lukas, AU - Jessen,Frank, Y1 - 2008/10/08/ PY - 2008/06/27/accepted PY - 2008/10/9/pubmed PY - 2009/2/10/medline PY - 2008/10/9/entrez SP - 323 EP - 9 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 26 IS - 4 N2 - BACKGROUND/AIMS: Alzheimer's disease (AD) is preceded by prodromal states. To determine the neuroanatomical basis for the relationship among such states, we assessed surface conformations of the hippocampus in AD, mild cognitive impairment (MCI) and subjective memory impairment (SMI). METHODS: Hippocampal surfaces were reconstructed three-dimensionally via large-deformation high-dimensional MRI brain mapping in 14 SMI, 15 MCI, 12 AD and 13 controls. The surfaces were divided a priori into lateral, superior and inferior-medial zones, which approximated the CA1, combined CA2, CA3, CA4 subfields and the subiculum, respectively. RESULTS: Group differences reached statistical significance in the lateral zone (F = 3.2, d.f. = 3, p = 0.033) and inferior-medial zone (F = 2.8, d.f. = 3, p = 0.049) subfields. The groups differed in total hippocampal volume only at the trend level (F = 2.5, d.f. = 3, p = 0.071). Surface deformation maps revealed similar patterns in SMI, MCI and AD subjects, but quantitative differences were significant only when comparing MCI and AD with control subjects. CONCLUSIONS: Hippocampal surface deformation in the CA1 subfield was most pronounced in AD, less so in MCI and minor in SMI subjects. These results suggest that hippocampus degeneration develops gradually in AD, and may be observable long before dementia is apparent. SN - 1421-9824 UR - https://www.unboundmedicine.com/medline/citation/18841017/Hippocampal_surface_analysis_in_subjective_memory_impairment_mild_cognitive_impairment_and_Alzheimer's_dementia_ L2 - https://www.karger.com?DOI=10.1159/000161057 DB - PRIME DP - Unbound Medicine ER -