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[Studies on chemical constituents from rhizome of Anemone flaccida].
Zhongguo Zhong Yao Za Zhi. 2008 Jul; 33(14):1696-9.ZZ

Abstract

OBJECTIVE

To study the chemical constituents from Anemone flaccida.

METHOD

Chemical constituents were isolated by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis.

RESULT

Twelve triterpenes were isolated and their structures were identified as follow: oleanolic acid (1), oleanolic acid 3-O-beta-D-glccopyranosyl-(1-->2)-beta-D-xylopyranoside (2), eleutheroside K (3), oleanolic acid 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranoside (4), oleanolic acid 3-O-beta-D-glccopyranosyl-(1-->2)-alpha-L-arabinofurnoside (5), oleanolic acid 3-O-beta-D-glccuronopyranose (6), oleanolic acid 3-O-beta-D-glccuronopyranose methyl ester (7), oleanolic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranosyl (8), oleanolic acid 3-O-beta-D-glccuronopyranose 28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (9), oleanolic acid 3-O-beta-D-glccopyranosyl methyl ester 28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (10), oleanolic acid 3-O-beta-D-glccopyranosyl-(1-->2)-beta-D-xylopyranosyl-28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (11), oleanolic acid 3-O-alpha-L-rh-amnopyranosyl-(1-->2)-alpha-L-arabinopyrnosyl-28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (12).

CONCLUSION

compounds 5-8, 10, 12 were isolated from this plant for the first time. Compounds 2, 5 and 11 showed positive anti-tumor activities.

Authors+Show Affiliations

Zhang LT
The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin 300072, China.
Takaishi Y
No affiliation info available
Zhang YW
No affiliation info available
Duan HQ
No affiliation info available

MeSH

AnemoneAntineoplastic AgentsCell ProliferationDrugs, Chinese HerbalEleutherococcusGlycosidesHeLa CellsHumansMagnetic Resonance SpectroscopyOleanolic AcidPlant ExtractsRhizomeSpectrometry, Mass, Electrospray Ionization

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18841769

Citation

Zhang, Lan-tian, et al. "[Studies On Chemical Constituents From Rhizome of Anemone Flaccida]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 33, no. 14, 2008, pp. 1696-9.
Zhang LT, Takaishi Y, Zhang YW, et al. [Studies on chemical constituents from rhizome of Anemone flaccida]. Zhongguo Zhong Yao Za Zhi. 2008;33(14):1696-9.
Zhang, L. T., Takaishi, Y., Zhang, Y. W., & Duan, H. Q. (2008). [Studies on chemical constituents from rhizome of Anemone flaccida]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 33(14), 1696-9.
Zhang LT, et al. [Studies On Chemical Constituents From Rhizome of Anemone Flaccida]. Zhongguo Zhong Yao Za Zhi. 2008;33(14):1696-9. PubMed PMID: 18841769.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Studies on chemical constituents from rhizome of Anemone flaccida]. AU - Zhang,Lan-tian, AU - Takaishi,Yoshihisa, AU - Zhang,Yan-wen, AU - Duan,Hong-quan, PY - 2008/10/10/pubmed PY - 2009/5/15/medline PY - 2008/10/10/entrez SP - 1696 EP - 9 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 33 IS - 14 N2 - OBJECTIVE: To study the chemical constituents from Anemone flaccida. METHOD: Chemical constituents were isolated by repeated column chromatography (silica gel, Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. RESULT: Twelve triterpenes were isolated and their structures were identified as follow: oleanolic acid (1), oleanolic acid 3-O-beta-D-glccopyranosyl-(1-->2)-beta-D-xylopyranoside (2), eleutheroside K (3), oleanolic acid 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranoside (4), oleanolic acid 3-O-beta-D-glccopyranosyl-(1-->2)-alpha-L-arabinofurnoside (5), oleanolic acid 3-O-beta-D-glccuronopyranose (6), oleanolic acid 3-O-beta-D-glccuronopyranose methyl ester (7), oleanolic acid 28-O-alpha-L-rhamnopyranosyl(1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranosyl (8), oleanolic acid 3-O-beta-D-glccuronopyranose 28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (9), oleanolic acid 3-O-beta-D-glccopyranosyl methyl ester 28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (10), oleanolic acid 3-O-beta-D-glccopyranosyl-(1-->2)-beta-D-xylopyranosyl-28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (11), oleanolic acid 3-O-alpha-L-rh-amnopyranosyl-(1-->2)-alpha-L-arabinopyrnosyl-28-O-alpha-L-rhamnopyranosyl (1-->4)-beta-D-glccopyranosyl (1-->6)-beta-D-glccopyranoside (12). CONCLUSION: compounds 5-8, 10, 12 were isolated from this plant for the first time. Compounds 2, 5 and 11 showed positive anti-tumor activities. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/18841769/[Studies_on_chemical_constituents_from_rhizome_of_Anemone_flaccida]_ DB - PRIME DP - Unbound Medicine ER -