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Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women.
Nutrition 2008 Nov-Dec; 24(11-12):1153-8N

Abstract

OBJECTIVE

To evaluate the effects of soy isoflavone supplementation on profile lipid and endogenous hormone levels.

METHODS

In this double-blind, placebo-controlled study, 47 postmenopausal women 47-66 y of age received 40 mg of isoflavone (n = 25) or 40 mg of casein placebo (n = 22). Cardiovascular risk factors were assessed by evaluating lipid profile at baseline and after 6 mo of treatment. To examine the effects of this regime on endogenous hormone levels, follicle-stimulating hormone and beta-estradiol were measured. Urinary isoflavone concentrations (genistein and daidzein) were measured as markers of both compliance and absorption using high performance liquid chromatography. Baseline characteristics were compared by the unpaired Student's t-test. Within-group changes were determined by paired Student's t-test and comparison between the isoflavone and casein placebo groups were determined by analysis of variance.

RESULTS

Lipid levels (low-density lipoprotein and total cholesterol) similarly decreased in both groups. High-density lipoprotein increased significantly in both groups and cannot thus be attributable to treatment; the reason for such variation is unknown and can be attributed to chance or to bias (even that of a real placebo effect in both groups or perhaps in spontaneous changes in exercise and dietary habits of patients after their inclusion). Furthermore, in both groups very low-density lipoprotein and triacylglycerol levels increased in a non-significant manner.

CONCLUSION

The results of the present study do not support any biologically significant estrogenic effects of isoflavone on the parameters assessed. Further research will be necessary to definitively assess the safety and efficacy of isoflavone.

Authors+Show Affiliations

Department of Clinical, Toxicological and Bromatological Analysis, Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18842392

Citation

Rios, Danyelle Romana A., et al. "Lack of Effects of Isoflavones On the Lipid Profile of Brazilian Postmenopausal Women." Nutrition (Burbank, Los Angeles County, Calif.), vol. 24, no. 11-12, 2008, pp. 1153-8.
Rios DR, Rodrigues ET, Cardoso AP, et al. Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women. Nutrition. 2008;24(11-12):1153-8.
Rios, D. R., Rodrigues, E. T., Cardoso, A. P., Montes, M. B., Franceschini, S. A., & Toloi, M. R. (2008). Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women. Nutrition (Burbank, Los Angeles County, Calif.), 24(11-12), pp. 1153-8. doi:10.1016/j.nut.2008.06.030.
Rios DR, et al. Lack of Effects of Isoflavones On the Lipid Profile of Brazilian Postmenopausal Women. Nutrition. 2008;24(11-12):1153-8. PubMed PMID: 18842392.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lack of effects of isoflavones on the lipid profile of Brazilian postmenopausal women. AU - Rios,Danyelle Romana A, AU - Rodrigues,Edna T, AU - Cardoso,Ana Paula Z, AU - Montes,Marlise Boneti A, AU - Franceschini,Sílvio A, AU - Toloi,Maria Regina T, Y1 - 2008/10/08/ PY - 2008/03/29/received PY - 2008/06/02/revised PY - 2008/06/19/accepted PY - 2008/10/10/pubmed PY - 2009/1/30/medline PY - 2008/10/10/entrez SP - 1153 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 24 IS - 11-12 N2 - OBJECTIVE: To evaluate the effects of soy isoflavone supplementation on profile lipid and endogenous hormone levels. METHODS: In this double-blind, placebo-controlled study, 47 postmenopausal women 47-66 y of age received 40 mg of isoflavone (n = 25) or 40 mg of casein placebo (n = 22). Cardiovascular risk factors were assessed by evaluating lipid profile at baseline and after 6 mo of treatment. To examine the effects of this regime on endogenous hormone levels, follicle-stimulating hormone and beta-estradiol were measured. Urinary isoflavone concentrations (genistein and daidzein) were measured as markers of both compliance and absorption using high performance liquid chromatography. Baseline characteristics were compared by the unpaired Student's t-test. Within-group changes were determined by paired Student's t-test and comparison between the isoflavone and casein placebo groups were determined by analysis of variance. RESULTS: Lipid levels (low-density lipoprotein and total cholesterol) similarly decreased in both groups. High-density lipoprotein increased significantly in both groups and cannot thus be attributable to treatment; the reason for such variation is unknown and can be attributed to chance or to bias (even that of a real placebo effect in both groups or perhaps in spontaneous changes in exercise and dietary habits of patients after their inclusion). Furthermore, in both groups very low-density lipoprotein and triacylglycerol levels increased in a non-significant manner. CONCLUSION: The results of the present study do not support any biologically significant estrogenic effects of isoflavone on the parameters assessed. Further research will be necessary to definitively assess the safety and efficacy of isoflavone. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/18842392/Lack_of_effects_of_isoflavones_on_the_lipid_profile_of_Brazilian_postmenopausal_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(08)00303-1 DB - PRIME DP - Unbound Medicine ER -