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The association of glycemic load and carbohydrate intake with colorectal cancer risk in the Multiethnic Cohort Study.
Am J Clin Nutr. 2008 Oct; 88(4):1074-82.AJ

Abstract

BACKGROUND

High-glycemic-load diets may increase colorectal cancer risk through hyperinsulinemic effects.

OBJECTIVE

We analyzed data for 191,004 participants in the Multiethnic Cohort Study to determine the risk of colorectal cancer associated with glycemic load (GL), carbohydrate, and sucrose and to ascertain whether this risk was modified by sex and ethnicity.

DESIGN

During 8 y of follow-up, 2379 incident cases of colorectal adenocarcinoma occurred. We used baseline quantitative food-frequency questionnaire data to assess usual dietary intake over the preceding year. Using Cox regression, we calculated adjusted relative risks (RRs) and 95% CIs for colorectal cancer associated with quintiles of GL, carbohydrate, and sucrose.

RESULTS

For both men and women in this cohort, white rice was the major contributor to GL. In multivariate models, RRs for colorectal cancer decreased significantly with increasing GL in women (RR for the highest quintile versus the lowest: 0.75; 95% CI: 0.57, 0.97; P for trend = 0.02) but not in men (RR: 1.15; 95% CI: 0.89, 1.48; P for trend = 0.19). Results for carbohydrate and sucrose were similar. The inverse association with GL was found in women of all ethnic groups (P for interaction = 0.58). In men, an interaction was found between ethnicity and GL (P < 0.01): white men had a positive association with increasing GL (RR: 1.69; 95% CI: 0.98, 2.92; P for trend < 0.01), but men of other ethnic groups did not.

CONCLUSION

GL and carbohydrate intake appear to protect against colorectal cancer in women in the Multiethnic Cohort, perhaps because a major source of GL is white rice.

Authors+Show Affiliations

Cancer Epidemiology Program, Cancer Research Center of Hawai'i, University of Hawai'i, Honolulu, HI 96813, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18842796

Citation

Howarth, Nancy C., et al. "The Association of Glycemic Load and Carbohydrate Intake With Colorectal Cancer Risk in the Multiethnic Cohort Study." The American Journal of Clinical Nutrition, vol. 88, no. 4, 2008, pp. 1074-82.
Howarth NC, Murphy SP, Wilkens LR, et al. The association of glycemic load and carbohydrate intake with colorectal cancer risk in the Multiethnic Cohort Study. Am J Clin Nutr. 2008;88(4):1074-82.
Howarth, N. C., Murphy, S. P., Wilkens, L. R., Henderson, B. E., & Kolonel, L. N. (2008). The association of glycemic load and carbohydrate intake with colorectal cancer risk in the Multiethnic Cohort Study. The American Journal of Clinical Nutrition, 88(4), 1074-82.
Howarth NC, et al. The Association of Glycemic Load and Carbohydrate Intake With Colorectal Cancer Risk in the Multiethnic Cohort Study. Am J Clin Nutr. 2008;88(4):1074-82. PubMed PMID: 18842796.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of glycemic load and carbohydrate intake with colorectal cancer risk in the Multiethnic Cohort Study. AU - Howarth,Nancy C, AU - Murphy,Suzanne P, AU - Wilkens,Lynne R, AU - Henderson,Brian E, AU - Kolonel,Laurence N, PY - 2008/10/10/pubmed PY - 2008/11/5/medline PY - 2008/10/10/entrez SP - 1074 EP - 82 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 88 IS - 4 N2 - BACKGROUND: High-glycemic-load diets may increase colorectal cancer risk through hyperinsulinemic effects. OBJECTIVE: We analyzed data for 191,004 participants in the Multiethnic Cohort Study to determine the risk of colorectal cancer associated with glycemic load (GL), carbohydrate, and sucrose and to ascertain whether this risk was modified by sex and ethnicity. DESIGN: During 8 y of follow-up, 2379 incident cases of colorectal adenocarcinoma occurred. We used baseline quantitative food-frequency questionnaire data to assess usual dietary intake over the preceding year. Using Cox regression, we calculated adjusted relative risks (RRs) and 95% CIs for colorectal cancer associated with quintiles of GL, carbohydrate, and sucrose. RESULTS: For both men and women in this cohort, white rice was the major contributor to GL. In multivariate models, RRs for colorectal cancer decreased significantly with increasing GL in women (RR for the highest quintile versus the lowest: 0.75; 95% CI: 0.57, 0.97; P for trend = 0.02) but not in men (RR: 1.15; 95% CI: 0.89, 1.48; P for trend = 0.19). Results for carbohydrate and sucrose were similar. The inverse association with GL was found in women of all ethnic groups (P for interaction = 0.58). In men, an interaction was found between ethnicity and GL (P < 0.01): white men had a positive association with increasing GL (RR: 1.69; 95% CI: 0.98, 2.92; P for trend < 0.01), but men of other ethnic groups did not. CONCLUSION: GL and carbohydrate intake appear to protect against colorectal cancer in women in the Multiethnic Cohort, perhaps because a major source of GL is white rice. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/18842796/The_association_of_glycemic_load_and_carbohydrate_intake_with_colorectal_cancer_risk_in_the_Multiethnic_Cohort_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/88.4.1074 DB - PRIME DP - Unbound Medicine ER -