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No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer.
Cancer Epidemiol Biomarkers Prev. 2008 Oct; 17(10):2585-93.CE

Abstract

BACKGROUND

Increased insulin-like growth factor (IGF)-I and IGF-II concentrations are related to increased colorectal cancer risk. Isoflavones have been associated with reduced colorectal cancer risk, and may affect the IGF system because of their weak estrogenic activity. The aim of the study was to investigate the effect of isolated isoflavones on serum concentrations of IGF system components.

MATERIALS AND METHODS

We conducted a randomized, placebo-controlled, double-blinded, crossover trial in four hospitals in the Netherlands to investigate the effect of an 8-week supplementation with red clover-derived isoflavones (84 mg/d) on serum IGF-I concentrations. In addition, serum concentrations of IGF-II and IGF binding proteins (IGFBP)-1, IGFBP-2, and IGFBP-3 were assessed. Normal colorectal tissue biopsies were obtained after the first intervention period and mRNA expression of IGF-I, IGF-II, IGFBP-3, and IGF-IR was evaluated. Our study population consisted of 34 postmenopausal women with a family history of colorectal cancer or a personal history of colorectal adenomas.

RESULTS

Isoflavone supplementation did not significantly affect serum concentrations of total IGF-I (mean relative within-person difference; IGF-I, -2.0%; 95% confidence interval, -8.0% to 3.9%). IGF-II and IGFBPs were also not significantly altered after isoflavone supplementation. Colorectal tissue mRNA expression of IGF system components did not significantly differ between individuals on isoflavone supplementation and those who received placebo.

CONCLUSIONS

The results of our trial, supported by a qualitative review of soy trials published to date, suggest that isoflavones do not significantly affect circulating levels of IGF system components. Increased levels of IGF-I, as observed in most of these trials, are likely due to simultaneous protein supplementation.

Authors+Show Affiliations

Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, the Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18842999

Citation

Vrieling, Alina, et al. "No Effect of Red Clover-derived Isoflavone Intervention On the Insulin-like Growth Factor System in Women at Increased Risk of Colorectal Cancer." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 10, 2008, pp. 2585-93.
Vrieling A, Rookus MA, Kampman E, et al. No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2585-93.
Vrieling, A., Rookus, M. A., Kampman, E., Bonfrer, J. M., Bosma, A., Cats, A., van Doorn, J., Korse, C. M., Witteman, B. J., van Leeuwen, F. E., van't Veer, L. J., & Voskuil, D. W. (2008). No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(10), 2585-93. https://doi.org/10.1158/1055-9965.EPI-08-0329
Vrieling A, et al. No Effect of Red Clover-derived Isoflavone Intervention On the Insulin-like Growth Factor System in Women at Increased Risk of Colorectal Cancer. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2585-93. PubMed PMID: 18842999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. AU - Vrieling,Alina, AU - Rookus,Matti A, AU - Kampman,Ellen, AU - Bonfrer,Johannes M G, AU - Bosma,Astrid, AU - Cats,Annemieke, AU - van Doorn,Jaap, AU - Korse,Catharina M, AU - Witteman,Ben J M, AU - van Leeuwen,Flora E, AU - van't Veer,Laura J, AU - Voskuil,Dorien W, PY - 2008/10/10/pubmed PY - 2008/12/17/medline PY - 2008/10/10/entrez SP - 2585 EP - 93 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 10 N2 - BACKGROUND: Increased insulin-like growth factor (IGF)-I and IGF-II concentrations are related to increased colorectal cancer risk. Isoflavones have been associated with reduced colorectal cancer risk, and may affect the IGF system because of their weak estrogenic activity. The aim of the study was to investigate the effect of isolated isoflavones on serum concentrations of IGF system components. MATERIALS AND METHODS: We conducted a randomized, placebo-controlled, double-blinded, crossover trial in four hospitals in the Netherlands to investigate the effect of an 8-week supplementation with red clover-derived isoflavones (84 mg/d) on serum IGF-I concentrations. In addition, serum concentrations of IGF-II and IGF binding proteins (IGFBP)-1, IGFBP-2, and IGFBP-3 were assessed. Normal colorectal tissue biopsies were obtained after the first intervention period and mRNA expression of IGF-I, IGF-II, IGFBP-3, and IGF-IR was evaluated. Our study population consisted of 34 postmenopausal women with a family history of colorectal cancer or a personal history of colorectal adenomas. RESULTS: Isoflavone supplementation did not significantly affect serum concentrations of total IGF-I (mean relative within-person difference; IGF-I, -2.0%; 95% confidence interval, -8.0% to 3.9%). IGF-II and IGFBPs were also not significantly altered after isoflavone supplementation. Colorectal tissue mRNA expression of IGF system components did not significantly differ between individuals on isoflavone supplementation and those who received placebo. CONCLUSIONS: The results of our trial, supported by a qualitative review of soy trials published to date, suggest that isoflavones do not significantly affect circulating levels of IGF system components. Increased levels of IGF-I, as observed in most of these trials, are likely due to simultaneous protein supplementation. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18842999/No_effect_of_red_clover_derived_isoflavone_intervention_on_the_insulin_like_growth_factor_system_in_women_at_increased_risk_of_colorectal_cancer_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18842999 DB - PRIME DP - Unbound Medicine ER -