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Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
Cancer Epidemiol Biomarkers Prev 2008; 17(10):2800-7CE

Abstract

Epidemiologic evidence supporting a protective role of calcium and vitamin D in colorectal carcinogenesis has been accumulating in Western populations, but it is limited in Asian populations, whose intake of calcium is relatively low. We investigated the association of intakes of these nutrients with colorectal cancer risk in Japanese. Study subjects were participants of a large-scale case-control study in Fukuoka, Japan. Diet was assessed through interview regarding 148 dietary items by showing typical foods or dishes on the display of a personal computer. In a multivariate analysis adjusting for potential confounding variables, calcium intake was significantly, inversely associated with colorectal cancer risk (P for trend=0.01); the odds ratio for the highest versus lowest quintile of calcium intake was 0.64 (95% confidence interval, 0.45-0.93). Higher levels of dietary vitamin D were significantly associated with decreased risk of colorectal cancer among those who had fewer chances of sunlight exposure at work or in leisure (P for trend=0.02). A decreased risk of colorectal cancer associated with high calcium intake was observed among those who had higher levels of vitamin D intake or among those who had a greater chance of daily sunlight exposure, but not among those with medium or lower intake of vitamin D or among those with potentially decreased sunlight exposure. These results add to support for a joint action of calcium and vitamin D in the prevention of colorectal carcinogenesis.

Authors+Show Affiliations

Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, 1-21-1 Toyama, Shinjuku-ku, Tokyo 162-8655, Japan. mizoue@ri.imcj.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18843026

Citation

Mizoue, Tetsuya, et al. "Calcium, Dairy Foods, Vitamin D, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 10, 2008, pp. 2800-7.
Mizoue T, Kimura Y, Toyomura K, et al. Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2800-7.
Mizoue, T., Kimura, Y., Toyomura, K., Nagano, J., Kono, S., Mibu, R., ... Imaizumi, N. (2008). Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(10), pp. 2800-7. doi:10.1158/1055-9965.EPI-08-0369.
Mizoue T, et al. Calcium, Dairy Foods, Vitamin D, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study. Cancer Epidemiol Biomarkers Prev. 2008;17(10):2800-7. PubMed PMID: 18843026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium, dairy foods, vitamin D, and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. AU - Mizoue,Tetsuya, AU - Kimura,Yasumi, AU - Toyomura,Kengo, AU - Nagano,Jun, AU - Kono,Suminori, AU - Mibu,Ryuichi, AU - Tanaka,Masao, AU - Kakeji,Yoshihiro, AU - Maehara,Yoshihiko, AU - Okamura,Takeshi, AU - Ikejiri,Koji, AU - Futami,Kitaroh, AU - Yasunami,Yohichi, AU - Maekawa,Takafumi, AU - Takenaka,Kenji, AU - Ichimiya,Hitoshi, AU - Imaizumi,Nobutoshi, PY - 2008/10/10/pubmed PY - 2008/12/17/medline PY - 2008/10/10/entrez SP - 2800 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 10 N2 - Epidemiologic evidence supporting a protective role of calcium and vitamin D in colorectal carcinogenesis has been accumulating in Western populations, but it is limited in Asian populations, whose intake of calcium is relatively low. We investigated the association of intakes of these nutrients with colorectal cancer risk in Japanese. Study subjects were participants of a large-scale case-control study in Fukuoka, Japan. Diet was assessed through interview regarding 148 dietary items by showing typical foods or dishes on the display of a personal computer. In a multivariate analysis adjusting for potential confounding variables, calcium intake was significantly, inversely associated with colorectal cancer risk (P for trend=0.01); the odds ratio for the highest versus lowest quintile of calcium intake was 0.64 (95% confidence interval, 0.45-0.93). Higher levels of dietary vitamin D were significantly associated with decreased risk of colorectal cancer among those who had fewer chances of sunlight exposure at work or in leisure (P for trend=0.02). A decreased risk of colorectal cancer associated with high calcium intake was observed among those who had higher levels of vitamin D intake or among those who had a greater chance of daily sunlight exposure, but not among those with medium or lower intake of vitamin D or among those with potentially decreased sunlight exposure. These results add to support for a joint action of calcium and vitamin D in the prevention of colorectal carcinogenesis. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18843026/Calcium_dairy_foods_vitamin_D_and_colorectal_cancer_risk:_the_Fukuoka_Colorectal_Cancer_Study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18843026 DB - PRIME DP - Unbound Medicine ER -