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Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients.
New Microbiol. 2008 Jul; 31(3):435-8.NM

Abstract

An HIV-infected patient started combination antiretroviral therapy with 13 CD4+ cells/microL. Despite sustained virological suppression over the following four years, the anemia did not resolve, and the CD4+ cell counts always remained below 200/microL until co-infection with Leishmania was diagnosed in October 2006 when the patient started complaining of persistent mild fever and asthenia. Once treatment for leishmaniasis was started with miltefosine, CD4+ cell count rose above 400/microL. A new drop in CD4+ cell count was observed when Leishmania DNA turned out again to be positive, but treatment with liposomal amphotericin-B restored immune recovery.

Authors+Show Affiliations

Division of Infectious Diseases, IRCCS San Raffaele, Milan, Italy. nicola.gianotti@hsr.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18843901

Citation

Gianotti, Nicola, et al. "Leishmania Infection Can Hamper Immune Recovery in Virologically Suppressed HIV-infected Patients." The New Microbiologica, vol. 31, no. 3, 2008, pp. 435-8.
Gianotti N, Maillard M, Gaiera G, et al. Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients. New Microbiol. 2008;31(3):435-8.
Gianotti, N., Maillard, M., Gaiera, G., Bestetti, A., Cernuschi, M., De Bona, A., Lazzarin, A., Cinque, P., & Bossolasco, S. (2008). Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients. The New Microbiologica, 31(3), 435-8.
Gianotti N, et al. Leishmania Infection Can Hamper Immune Recovery in Virologically Suppressed HIV-infected Patients. New Microbiol. 2008;31(3):435-8. PubMed PMID: 18843901.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leishmania infection can hamper immune recovery in virologically suppressed HIV-infected patients. AU - Gianotti,Nicola, AU - Maillard,Myriam, AU - Gaiera,Giovanni, AU - Bestetti,Arabella, AU - Cernuschi,Massimo, AU - De Bona,Anna, AU - Lazzarin,Adriano, AU - Cinque,Paola, AU - Bossolasco,Simona, PY - 2008/10/11/pubmed PY - 2008/11/19/medline PY - 2008/10/11/entrez SP - 435 EP - 8 JF - The new microbiologica JO - New Microbiol VL - 31 IS - 3 N2 - An HIV-infected patient started combination antiretroviral therapy with 13 CD4+ cells/microL. Despite sustained virological suppression over the following four years, the anemia did not resolve, and the CD4+ cell counts always remained below 200/microL until co-infection with Leishmania was diagnosed in October 2006 when the patient started complaining of persistent mild fever and asthenia. Once treatment for leishmaniasis was started with miltefosine, CD4+ cell count rose above 400/microL. A new drop in CD4+ cell count was observed when Leishmania DNA turned out again to be positive, but treatment with liposomal amphotericin-B restored immune recovery. SN - 1121-7138 UR - https://www.unboundmedicine.com/medline/citation/18843901/Leishmania_infection_can_hamper_immune_recovery_in_virologically_suppressed_HIV_infected_patients_ L2 - http://www.newmicrobiologica.org/PUB/allegati_pdf/2008/3/435.pdf DB - PRIME DP - Unbound Medicine ER -