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[Study on the genetic characteristics of the avian influenza virus strain A/Zhejiang/16/2006].

Abstract

OBJECTIVE

To study the genetic characteristics of avian influenza virus strain A/Zhejiang/ 16/2006 which was isolated from the case first reported in Zhejiang province.

METHODS

Complete genome of A/Zhejiang/16/2006 including eight segments were sequenced and compared on the genetic homogeneity with sequences of the similar strains provided through domestic and overseas sources.

RESULTS

There were 11 amino acids showing differences on HA between A/Zhejiang/16/2006 and the H5N1 isolates of neighboring countries, but these differences had not affected the stability of glycosylation sites. In the NA region, 20 amino acids located in the 49th to 68th position were found absent in the isolates obtained after 1997. Eight segments of H5N1 isolates, circulating in the mainland of China in the recent years, formed a separate branch compared to the strains in neighboring countries and there was also obviously different from the strains isolated in Hong Kong and Guangzhou in 1996 and 1997. However, several Chinese strains were close to the Hong Kong strains isolated in 1997 but diffferent from the current strains in the phylogenetic tree.

CONCLUSION

The influenza virus strain A/Zhejiang/16/2006 formed a separate branch with the strains isolated in the mainland of China in the past years but it presented an obvious difference with the isolates from the neighboring countries.

Authors+Show Affiliations

Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310009, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18843992

Citation

Lu, Yi-Yu, et al. "[Study On the Genetic Characteristics of the Avian Influenza Virus Strain A/Zhejiang/16/2006]." Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, vol. 29, no. 4, 2008, pp. 351-5.
Lu YY, Yan JY, Xu CP, et al. [Study on the genetic characteristics of the avian influenza virus strain A/Zhejiang/16/2006]. Zhonghua Liu Xing Bing Xue Za Zhi. 2008;29(4):351-5.
Lu, Y. Y., Yan, J. Y., Xu, C. P., Mao, H. Y., Feng, Y., Chen, Y., ... Shi, W. (2008). [Study on the genetic characteristics of the avian influenza virus strain A/Zhejiang/16/2006]. Zhonghua Liu Xing Bing Xue Za Zhi = Zhonghua Liuxingbingxue Zazhi, 29(4), pp. 351-5.
Lu YY, et al. [Study On the Genetic Characteristics of the Avian Influenza Virus Strain A/Zhejiang/16/2006]. Zhonghua Liu Xing Bing Xue Za Zhi. 2008;29(4):351-5. PubMed PMID: 18843992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Study on the genetic characteristics of the avian influenza virus strain A/Zhejiang/16/2006]. AU - Lu,Yi-Yu, AU - Yan,Ju-Ying, AU - Xu,Chang-Ping, AU - Mao,Hai-Yan, AU - Feng,Yan, AU - Chen,Yin, AU - Li,Zhen, AU - Li,Min-Hong, AU - Shi,Wen, PY - 2008/10/11/pubmed PY - 2010/5/29/medline PY - 2008/10/11/entrez SP - 351 EP - 5 JF - Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi JO - Zhonghua Liu Xing Bing Xue Za Zhi VL - 29 IS - 4 N2 - OBJECTIVE: To study the genetic characteristics of avian influenza virus strain A/Zhejiang/ 16/2006 which was isolated from the case first reported in Zhejiang province. METHODS: Complete genome of A/Zhejiang/16/2006 including eight segments were sequenced and compared on the genetic homogeneity with sequences of the similar strains provided through domestic and overseas sources. RESULTS: There were 11 amino acids showing differences on HA between A/Zhejiang/16/2006 and the H5N1 isolates of neighboring countries, but these differences had not affected the stability of glycosylation sites. In the NA region, 20 amino acids located in the 49th to 68th position were found absent in the isolates obtained after 1997. Eight segments of H5N1 isolates, circulating in the mainland of China in the recent years, formed a separate branch compared to the strains in neighboring countries and there was also obviously different from the strains isolated in Hong Kong and Guangzhou in 1996 and 1997. However, several Chinese strains were close to the Hong Kong strains isolated in 1997 but diffferent from the current strains in the phylogenetic tree. CONCLUSION: The influenza virus strain A/Zhejiang/16/2006 formed a separate branch with the strains isolated in the mainland of China in the past years but it presented an obvious difference with the isolates from the neighboring countries. SN - 0254-6450 UR - https://www.unboundmedicine.com/medline/citation/18843992/[Study_on_the_genetic_characteristics_of_the_avian_influenza_virus_strain_A/Zhejiang/16/2006]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=0254-6450&year=2008&vol=29&issue=4&fpage=351 DB - PRIME DP - Unbound Medicine ER -