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[Effects of graft compositions on hematopoietic reconstitution and graft-versus-host disease in related donor peripheral blood stem cell transplantation].
Zhonghua Xue Ye Xue Za Zhi. 2008 May; 29(5):333-6.ZX

Abstract

OBJECTIVE

To explore the effects of graft composition on hematopoietic reconstitution and graft-versus-host disease (GVHD) in HLA-identical related donor peripheral blood stem cell transplantation (PBSCT) for hematological malignancies.

METHODS

The relationship between the number of graft composition and their hematopoietic reconstitution and GVHD in 107 patients with hematological malignancies undergoing HLA-identical related donor PBSCT was retrospectively analyzed.

RESULTS

None of the graft composition numbers had correlation with the time of neutrophil reconstitution. There was a negative correlation between the number of mononuclear cells (MNCs) or CD34+ cells and the time of platelet reconstitution (P < 0.05) with the absolute correlation coefficients below 0.4, and so did between the number of CD34+ or CD34+ CD38- cells and the development of acute GVHD (P < 0.05) and their absolute correlation coefficients. Each lymphocyte subset number had no correlation with acute GVHD. There was a positive correlation between the number of CD25+ CD4+, CD3+ or CD4+ CD3+ cells or CD4+ /CD8+ ratio and the development of chronic GVHD (P < 0.05). And the correlation coefficients all exceeded 0.4, more over, CD25+ CD4+ cells number reached up to 0.78. CD34+, CD34+ CD38- cells number had no correlation with chronic GVHD.

CONCLUSION

In HLA-identical related donor PBSCT, further increasing infused MNC, CD34+, CD34+ CD38- cells can no more accelerated hematopoietic reconstitution after these cells attained their threshold values, otherwise the incidence of cGVHD might increase due to the increase of the accompanied lymphocytes.

Authors+Show Affiliations

Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

18844073

Citation

Zhan, Yu, et al. "[Effects of Graft Compositions On Hematopoietic Reconstitution and Graft-versus-host Disease in Related Donor Peripheral Blood Stem Cell Transplantation]." Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, vol. 29, no. 5, 2008, pp. 333-6.
Zhan Y, Yi ZS, Wei YQ, et al. [Effects of graft compositions on hematopoietic reconstitution and graft-versus-host disease in related donor peripheral blood stem cell transplantation]. Zhonghua Xue Ye Xue Za Zhi. 2008;29(5):333-6.
Zhan, Y., Yi, Z. S., Wei, Y. Q., Huang, F., Zhang, Y. M., Fan, Z. P., & Feng, R. (2008). [Effects of graft compositions on hematopoietic reconstitution and graft-versus-host disease in related donor peripheral blood stem cell transplantation]. Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi, 29(5), 333-6.
Zhan Y, et al. [Effects of Graft Compositions On Hematopoietic Reconstitution and Graft-versus-host Disease in Related Donor Peripheral Blood Stem Cell Transplantation]. Zhonghua Xue Ye Xue Za Zhi. 2008;29(5):333-6. PubMed PMID: 18844073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of graft compositions on hematopoietic reconstitution and graft-versus-host disease in related donor peripheral blood stem cell transplantation]. AU - Zhan,Yu, AU - Yi,Zheng-Shan, AU - Wei,Yong-Qiang, AU - Huang,Fen, AU - Zhang,Yong-Min, AU - Fan,Zhi-Ping, AU - Feng,Ru, PY - 2008/10/11/pubmed PY - 2010/4/9/medline PY - 2008/10/11/entrez SP - 333 EP - 6 JF - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi JO - Zhonghua Xue Ye Xue Za Zhi VL - 29 IS - 5 N2 - OBJECTIVE: To explore the effects of graft composition on hematopoietic reconstitution and graft-versus-host disease (GVHD) in HLA-identical related donor peripheral blood stem cell transplantation (PBSCT) for hematological malignancies. METHODS: The relationship between the number of graft composition and their hematopoietic reconstitution and GVHD in 107 patients with hematological malignancies undergoing HLA-identical related donor PBSCT was retrospectively analyzed. RESULTS: None of the graft composition numbers had correlation with the time of neutrophil reconstitution. There was a negative correlation between the number of mononuclear cells (MNCs) or CD34+ cells and the time of platelet reconstitution (P < 0.05) with the absolute correlation coefficients below 0.4, and so did between the number of CD34+ or CD34+ CD38- cells and the development of acute GVHD (P < 0.05) and their absolute correlation coefficients. Each lymphocyte subset number had no correlation with acute GVHD. There was a positive correlation between the number of CD25+ CD4+, CD3+ or CD4+ CD3+ cells or CD4+ /CD8+ ratio and the development of chronic GVHD (P < 0.05). And the correlation coefficients all exceeded 0.4, more over, CD25+ CD4+ cells number reached up to 0.78. CD34+, CD34+ CD38- cells number had no correlation with chronic GVHD. CONCLUSION: In HLA-identical related donor PBSCT, further increasing infused MNC, CD34+, CD34+ CD38- cells can no more accelerated hematopoietic reconstitution after these cells attained their threshold values, otherwise the incidence of cGVHD might increase due to the increase of the accompanied lymphocytes. SN - 0253-2727 UR - https://www.unboundmedicine.com/medline/citation/18844073/[Effects_of_graft_compositions_on_hematopoietic_reconstitution_and_graft_versus_host_disease_in_related_donor_peripheral_blood_stem_cell_transplantation]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0253-2727&amp;year=2008&amp;vol=29&amp;issue=5&amp;fpage=333 DB - PRIME DP - Unbound Medicine ER -