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Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.
Phytother Res 2009; 23(5):597-602PR

Abstract

Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders.

Authors+Show Affiliations

Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18844286

Citation

Scuderi, Caterina, et al. "Cannabidiol in Medicine: a Review of Its Therapeutic Potential in CNS Disorders." Phytotherapy Research : PTR, vol. 23, no. 5, 2009, pp. 597-602.
Scuderi C, Filippis DD, Iuvone T, et al. Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Phytother Res. 2009;23(5):597-602.
Scuderi, C., Filippis, D. D., Iuvone, T., Blasio, A., Steardo, A., & Esposito, G. (2009). Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. Phytotherapy Research : PTR, 23(5), pp. 597-602. doi:10.1002/ptr.2625.
Scuderi C, et al. Cannabidiol in Medicine: a Review of Its Therapeutic Potential in CNS Disorders. Phytother Res. 2009;23(5):597-602. PubMed PMID: 18844286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. AU - Scuderi,Caterina, AU - Filippis,Daniele De, AU - Iuvone,Teresa, AU - Blasio,Angelo, AU - Steardo,Antonio, AU - Esposito,Giuseppe, PY - 2008/10/11/pubmed PY - 2009/5/23/medline PY - 2008/10/11/entrez SP - 597 EP - 602 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 5 N2 - Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18844286/abstract/Cannabidiol_in_medicine:_a_review_of_its_therapeutic_potential_in_CNS_disorders_ L2 - https://doi.org/10.1002/ptr.2625 DB - PRIME DP - Unbound Medicine ER -