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Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders.

Abstract

Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, Rome, Italy.

    , , , ,

    Source

    Phytotherapy research : PTR 23:5 2009 May pg 597-602

    MeSH

    Animals
    Cannabidiol
    Cannabis
    Central Nervous System Diseases
    Humans

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    18844286

    Citation

    TY - JOUR T1 - Cannabidiol in medicine: a review of its therapeutic potential in CNS disorders. AU - Scuderi,Caterina, AU - Filippis,Daniele De, AU - Iuvone,Teresa, AU - Blasio,Angelo, AU - Steardo,Antonio, AU - Esposito,Giuseppe, PY - 2008/10/11/pubmed PY - 2009/5/23/medline PY - 2008/10/11/entrez SP - 597 EP - 602 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 5 N2 - Cannabidiol (CBD) is the main non-psychotropic component of the glandular hairs of Cannabis sativa. It displays a plethora of actions including anticonvulsive, sedative, hypnotic, antipsychotic, antiinflammatory and neuroprotective properties. However, it is well established that CBD produces its biological effects without exerting significant intrinsic activity upon cannabinoid receptors. For this reason, CBD lacks the unwanted psychotropic effects characteristic of marijuana derivatives, so representing one of the bioactive constituents of Cannabis sativa with the highest potential for therapeutic use.The present review reports the pharmacological profile of CBD and summarizes results from preclinical and clinical studies utilizing CBD, alone or in combination with other phytocannabinoids, for the treatment of a number of CNS disorders. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18844286/abstract/Cannabidiol_in_medicine:_a_review_of_its_therapeutic_potential_in_CNS_disorders_ L2 - https://doi.org/10.1002/ptr.2625 ER -