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Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs.
Phytother Res. 2009 Mar; 23(3):317-23.PR

Abstract

Xiexin decoction (XXD), a classic pyretolysis formula, is composed of Rhei Rhizoma (DH), Radix Scutellaria (HQ) and Coptis Chinensis (HL) and is commonly used in the clinical setting. The aim of this study was to investigate the pharmacokinetic differences of the five anthraquinones in rats after oral administration of XXD and different combinations of its constituent herbs. Twenty rats were randomly divided into four groups and were administered one of the four extracts: DH, DH-HQ, DH-HL and XXD (DH-HQ-HL) via intragastric gavage. Anthraquinone concentrations in plasma were determined by an HPLC technique. Pharmacokinetic parameters were calculated from the plasma concentration-time data. Compared with DH alone, the DH-HL combination decreased C(max) of all five anthraquinones and AUC of four anthraquinones (except physcion), and the DH-HQ combination decreased AUC of aloe-emodin and C(max) of rhein. Finally, XXD increased AUC of all five anthraquinones compared with DH-HL combination. These results showed that the oral bioavailabilities of five anthraquinones were decreased significantly by combining DH with HL, whereas HQ weakened the effect of HL that inhibited the absorption of anthraquinones.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Yan D
Laboratory of Pharmacokinetics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Ma Y
No affiliation info available
Shi R
No affiliation info available
Xu D
No affiliation info available
Zhang N
No affiliation info available

MeSH

Administration, OralAnimalsAnthraquinonesChromatography, High Pressure LiquidCoptisDrugs, Chinese HerbalPlant ExtractsPlant PreparationsRandom AllocationRatsRats, Sprague-DawleyReproducibility of ResultsRheumScutellaria baicalensis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18844291

Citation

Yan, Dongming, et al. "Pharmacokinetics of Anthraquinones in Xiexin Decoction and in Different Combinations of Its Constituent Herbs." Phytotherapy Research : PTR, vol. 23, no. 3, 2009, pp. 317-23.
Yan D, Ma Y, Shi R, et al. Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs. Phytother Res. 2009;23(3):317-23.
Yan, D., Ma, Y., Shi, R., Xu, D., & Zhang, N. (2009). Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs. Phytotherapy Research : PTR, 23(3), 317-23. https://doi.org/10.1002/ptr.2622
Yan D, et al. Pharmacokinetics of Anthraquinones in Xiexin Decoction and in Different Combinations of Its Constituent Herbs. Phytother Res. 2009;23(3):317-23. PubMed PMID: 18844291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacokinetics of anthraquinones in Xiexin decoction and in different combinations of its constituent herbs. AU - Yan,Dongming, AU - Ma,Yueming, AU - Shi,Rong, AU - Xu,Desheng, AU - Zhang,Ning, PY - 2008/10/11/pubmed PY - 2009/3/31/medline PY - 2008/10/11/entrez SP - 317 EP - 23 JF - Phytotherapy research : PTR JO - Phytother Res VL - 23 IS - 3 N2 - Xiexin decoction (XXD), a classic pyretolysis formula, is composed of Rhei Rhizoma (DH), Radix Scutellaria (HQ) and Coptis Chinensis (HL) and is commonly used in the clinical setting. The aim of this study was to investigate the pharmacokinetic differences of the five anthraquinones in rats after oral administration of XXD and different combinations of its constituent herbs. Twenty rats were randomly divided into four groups and were administered one of the four extracts: DH, DH-HQ, DH-HL and XXD (DH-HQ-HL) via intragastric gavage. Anthraquinone concentrations in plasma were determined by an HPLC technique. Pharmacokinetic parameters were calculated from the plasma concentration-time data. Compared with DH alone, the DH-HL combination decreased C(max) of all five anthraquinones and AUC of four anthraquinones (except physcion), and the DH-HQ combination decreased AUC of aloe-emodin and C(max) of rhein. Finally, XXD increased AUC of all five anthraquinones compared with DH-HL combination. These results showed that the oral bioavailabilities of five anthraquinones were decreased significantly by combining DH with HL, whereas HQ weakened the effect of HL that inhibited the absorption of anthraquinones. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/18844291/Pharmacokinetics_of_anthraquinones_in_Xiexin_decoction_and_in_different_combinations_of_its_constituent_herbs_ DB - PRIME DP - Unbound Medicine ER -