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Androgens and hair growth.
Dermatol Ther. 2008 Sep-Oct; 21(5):314-28.DT

Abstract

Hair's importance in human communication means that abnormalities like excess hair in hirsutism or hair loss in alopecia cause psychological distress. Androgens are the main regulator of human hair follicles, changing small vellus follicles producing tiny, virtually invisible hairs into larger intermediate and terminal follicles making bigger, pigmented hairs. The response to androgens varies with the body site as it is specific to the hair follicle itself. Normally around puberty, androgens stimulate axillary and pubic hair in both sexes, plus the beard, etc. in men, while later they may also inhibit scalp hair growth causing androgenetic alopecia. Androgens act within the follicle to alter the mesenchyme-epithelial cell interactions, changing the length of time the hair is growing, the dermal papilla size and dermal papilla cell, keratinocyte and melanocyte activity. Greater understanding of the mechanisms of androgen action in follicles should improve therapies for poorly controlled hair disorders like hirsutism and alopecia.

Authors+Show Affiliations

Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK. v.a.randall@bradford.ac.uk.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18844710

Citation

Randall, Valerie Anne. "Androgens and Hair Growth." Dermatologic Therapy, vol. 21, no. 5, 2008, pp. 314-28.
Randall VA. Androgens and hair growth. Dermatol Ther. 2008;21(5):314-28.
Randall, V. A. (2008). Androgens and hair growth. Dermatologic Therapy, 21(5), 314-28. https://doi.org/10.1111/j.1529-8019.2008.00214.x
Randall VA. Androgens and Hair Growth. Dermatol Ther. 2008 Sep-Oct;21(5):314-28. PubMed PMID: 18844710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgens and hair growth. A1 - Randall,Valerie Anne, PY - 2008/10/11/pubmed PY - 2009/1/8/medline PY - 2008/10/11/entrez SP - 314 EP - 28 JF - Dermatologic therapy JO - Dermatol Ther VL - 21 IS - 5 N2 - Hair's importance in human communication means that abnormalities like excess hair in hirsutism or hair loss in alopecia cause psychological distress. Androgens are the main regulator of human hair follicles, changing small vellus follicles producing tiny, virtually invisible hairs into larger intermediate and terminal follicles making bigger, pigmented hairs. The response to androgens varies with the body site as it is specific to the hair follicle itself. Normally around puberty, androgens stimulate axillary and pubic hair in both sexes, plus the beard, etc. in men, while later they may also inhibit scalp hair growth causing androgenetic alopecia. Androgens act within the follicle to alter the mesenchyme-epithelial cell interactions, changing the length of time the hair is growing, the dermal papilla size and dermal papilla cell, keratinocyte and melanocyte activity. Greater understanding of the mechanisms of androgen action in follicles should improve therapies for poorly controlled hair disorders like hirsutism and alopecia. SN - 1529-8019 UR - https://www.unboundmedicine.com/medline/citation/18844710/Androgens_and_hair_growth_ DB - PRIME DP - Unbound Medicine ER -
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