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Regulation of vitamin D homeostasis: implications for the immune system.
Nutr Rev. 2008 Oct; 66(10 Suppl 2):S125-34.NR

Abstract

Vitamin D homeostasis in the immune system is the focus of this review. The production of both the activating (25- and 1alpha-hydroxylase) and the metabolizing (24-hydroxylase) enzymes by cells of the immune system itself, indicates that 1,25(OH)(2)D(3) can be produced locally in immune reaction sites. Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities.

Authors+Show Affiliations

The Laboratory for Experimental Medicine and Endocrinology (LEGENDO), Katholieke Universiteit Leuven , Leuven, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18844839

Citation

van Etten, Evelyne, et al. "Regulation of Vitamin D Homeostasis: Implications for the Immune System." Nutrition Reviews, vol. 66, no. 10 Suppl 2, 2008, pp. S125-34.
van Etten E, Stoffels K, Gysemans C, et al. Regulation of vitamin D homeostasis: implications for the immune system. Nutr Rev. 2008;66(10 Suppl 2):S125-34.
van Etten, E., Stoffels, K., Gysemans, C., Mathieu, C., & Overbergh, L. (2008). Regulation of vitamin D homeostasis: implications for the immune system. Nutrition Reviews, 66(10 Suppl 2), S125-34. https://doi.org/10.1111/j.1753-4887.2008.00096.x
van Etten E, et al. Regulation of Vitamin D Homeostasis: Implications for the Immune System. Nutr Rev. 2008;66(10 Suppl 2):S125-34. PubMed PMID: 18844839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of vitamin D homeostasis: implications for the immune system. AU - van Etten,Evelyne, AU - Stoffels,Katinka, AU - Gysemans,Conny, AU - Mathieu,Chantal, AU - Overbergh,Lut, PY - 2008/12/5/pubmed PY - 2009/2/27/medline PY - 2008/12/5/entrez SP - S125 EP - 34 JF - Nutrition reviews JO - Nutr. Rev. VL - 66 IS - 10 Suppl 2 N2 - Vitamin D homeostasis in the immune system is the focus of this review. The production of both the activating (25- and 1alpha-hydroxylase) and the metabolizing (24-hydroxylase) enzymes by cells of the immune system itself, indicates that 1,25(OH)(2)D(3) can be produced locally in immune reaction sites. Moreover, the strict regulation of these enzymes by immune signals is highly suggestive for an autocrine/paracrine role in the immune system, and opens new treatment possibilities. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/18844839/Regulation_of_vitamin_D_homeostasis:_implications_for_the_immune_system_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/j.1753-4887.2008.00096.x DB - PRIME DP - Unbound Medicine ER -