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Sex hormones and cognitive decline in elderly men.
Psychoneuroendocrinology. 2009 Jan; 34(1):27-31.P

Abstract

Decline of cognitive function with age may be due, in part, to hormonal changes and it has been hypothesized that higher levels of endogenous sex hormones preserve brain function. The aim of this prospective cohort study was to determine the relative contribution of endogenous sex hormones to cognitive decline in a population-based sample of 242 elderly men aged 73-91 at baseline. Endogenous sex hormone levels were measured at baseline and participants underwent a cognitive assessment at baseline and at follow-up after 4 years. Higher estradiol (total and bioavailable) and estrone levels were associated with an increased risk of cognitive decline in elderly men independent of age, cardiovascular risk factors, atherosclerosis, and APOE genotype. These findings do not support the hypotheses that higher levels of endogenous sex hormones preserve brain function.

Authors+Show Affiliations

Department of Geriatrics, University Medical Center Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

18845400

Citation

Muller, Majon, et al. "Sex Hormones and Cognitive Decline in Elderly Men." Psychoneuroendocrinology, vol. 34, no. 1, 2009, pp. 27-31.
Muller M, van den Beld AW, Grobbee DE, et al. Sex hormones and cognitive decline in elderly men. Psychoneuroendocrinology. 2009;34(1):27-31.
Muller, M., van den Beld, A. W., Grobbee, D. E., de Jong, F. H., & Lamberts, S. W. (2009). Sex hormones and cognitive decline in elderly men. Psychoneuroendocrinology, 34(1), 27-31. https://doi.org/10.1016/j.psyneuen.2008.08.008
Muller M, et al. Sex Hormones and Cognitive Decline in Elderly Men. Psychoneuroendocrinology. 2009;34(1):27-31. PubMed PMID: 18845400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex hormones and cognitive decline in elderly men. AU - Muller,Majon, AU - van den Beld,Annewieke W, AU - Grobbee,Diederick E, AU - de Jong,Frank H, AU - Lamberts,Steven W J, Y1 - 2008/10/08/ PY - 2007/12/17/received PY - 2008/05/08/revised PY - 2008/08/11/accepted PY - 2008/10/11/pubmed PY - 2009/3/25/medline PY - 2008/10/11/entrez SP - 27 EP - 31 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 34 IS - 1 N2 - Decline of cognitive function with age may be due, in part, to hormonal changes and it has been hypothesized that higher levels of endogenous sex hormones preserve brain function. The aim of this prospective cohort study was to determine the relative contribution of endogenous sex hormones to cognitive decline in a population-based sample of 242 elderly men aged 73-91 at baseline. Endogenous sex hormone levels were measured at baseline and participants underwent a cognitive assessment at baseline and at follow-up after 4 years. Higher estradiol (total and bioavailable) and estrone levels were associated with an increased risk of cognitive decline in elderly men independent of age, cardiovascular risk factors, atherosclerosis, and APOE genotype. These findings do not support the hypotheses that higher levels of endogenous sex hormones preserve brain function. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/18845400/Sex_hormones_and_cognitive_decline_in_elderly_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(08)00213-8 DB - PRIME DP - Unbound Medicine ER -