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Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal.
J Am Coll Nutr. 2008 Oct; 27(5):588-95.JA

Abstract

OBJECTIVE

Plant sterols (PS) consumed as a snack may not have the same cholesterol-lowering potential as when consumed with a meal due to poor solubilization. It was hypothesized that the consumption of a single dose, low-fat yogurt rich in PS (1.6 g/d) with a meal over an afternoon snack will lead to favourable changes in plasma lipids, plasma PS concentrations, and cholesterol synthesis without negatively affecting alpha-tocopherol or carotenoids levels.

METHODS

Twenty-six hyperlipidemic males and females completed the randomized trial of three phases (control, single PS dose consumed with a meal, or single PS dose as an afternoon snack) while consuming controlled, low-fat diets. Plasma lipids, cholesterol synthesis rates, plasma PS and serum fat-soluble antioxidants were measured at baseline and after 4 weeks.

RESULTS

Endpoint total cholesterol (TC) levels after the PS snack phase were decreased (p = 0.04) (5.30 +/- 0.2 mmol/L) compared to the control phase (5.53 +/- 0.2 mmol/L). However, endpoints for TC (5.37 +/- 0.2 mmol/L) for PS dose with a meal were comparable to control phase. Low-density lipoprotein-cholesterol tended to be different (p = 0.06) at the end of the intervention phases (3.51 +/- 0.1, 3.43 +/- 0.1, and 3.33 +/- 0.1 mmol/L; control, meal and snack, respectively). Cholesterol fractional synthesis rates were higher (p = 0.007) by 25.8% and 19.5% at the end of the snack and meal phases, respectively, compared with the control phase. Plasma campesterol and beta-sitosterol concentrations, adjusted for TC, were higher (p < 0.01) in the snack phase (2.30 +/- 0.3 and 0.54 +/- 0.1 micromol/mmol, respectively) and in the meal phase (2.00 +/- 0.3 and 0.51 +/- 0.1 micromol/mmol, respectively) when compared to the control phase (1.81 +/- 0.3 and 0.40 +/- 0.1 micromol/mmol, respectively). No changes in alpha-tocopherol or carotenoids levels were detected after adjusting for TC, for all phases.

CONCLUSION

These results indicate that a single dose of PS in low-fat yogurt, provided as a snack, lowers cholesterol levels but does not alter fat-soluble vitamin or carotenoid concentrations in hyperlipidemic participants.

Authors+Show Affiliations

School of Dietetics and Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18845709

Citation

Rudkowska, Iwona, et al. "Cholesterol-lowering Efficacy of Plant Sterols in Low-fat Yogurt Consumed as a Snack or With a Meal." Journal of the American College of Nutrition, vol. 27, no. 5, 2008, pp. 588-95.
Rudkowska I, AbuMweis SS, Nicolle C, et al. Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. J Am Coll Nutr. 2008;27(5):588-95.
Rudkowska, I., AbuMweis, S. S., Nicolle, C., & Jones, P. J. (2008). Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. Journal of the American College of Nutrition, 27(5), 588-95.
Rudkowska I, et al. Cholesterol-lowering Efficacy of Plant Sterols in Low-fat Yogurt Consumed as a Snack or With a Meal. J Am Coll Nutr. 2008;27(5):588-95. PubMed PMID: 18845709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol-lowering efficacy of plant sterols in low-fat yogurt consumed as a snack or with a meal. AU - Rudkowska,Iwona, AU - AbuMweis,Suhad S, AU - Nicolle,Catherine, AU - Jones,Peter J H, PY - 2008/10/11/pubmed PY - 2009/1/9/medline PY - 2008/10/11/entrez SP - 588 EP - 95 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 27 IS - 5 N2 - OBJECTIVE: Plant sterols (PS) consumed as a snack may not have the same cholesterol-lowering potential as when consumed with a meal due to poor solubilization. It was hypothesized that the consumption of a single dose, low-fat yogurt rich in PS (1.6 g/d) with a meal over an afternoon snack will lead to favourable changes in plasma lipids, plasma PS concentrations, and cholesterol synthesis without negatively affecting alpha-tocopherol or carotenoids levels. METHODS: Twenty-six hyperlipidemic males and females completed the randomized trial of three phases (control, single PS dose consumed with a meal, or single PS dose as an afternoon snack) while consuming controlled, low-fat diets. Plasma lipids, cholesterol synthesis rates, plasma PS and serum fat-soluble antioxidants were measured at baseline and after 4 weeks. RESULTS: Endpoint total cholesterol (TC) levels after the PS snack phase were decreased (p = 0.04) (5.30 +/- 0.2 mmol/L) compared to the control phase (5.53 +/- 0.2 mmol/L). However, endpoints for TC (5.37 +/- 0.2 mmol/L) for PS dose with a meal were comparable to control phase. Low-density lipoprotein-cholesterol tended to be different (p = 0.06) at the end of the intervention phases (3.51 +/- 0.1, 3.43 +/- 0.1, and 3.33 +/- 0.1 mmol/L; control, meal and snack, respectively). Cholesterol fractional synthesis rates were higher (p = 0.007) by 25.8% and 19.5% at the end of the snack and meal phases, respectively, compared with the control phase. Plasma campesterol and beta-sitosterol concentrations, adjusted for TC, were higher (p < 0.01) in the snack phase (2.30 +/- 0.3 and 0.54 +/- 0.1 micromol/mmol, respectively) and in the meal phase (2.00 +/- 0.3 and 0.51 +/- 0.1 micromol/mmol, respectively) when compared to the control phase (1.81 +/- 0.3 and 0.40 +/- 0.1 micromol/mmol, respectively). No changes in alpha-tocopherol or carotenoids levels were detected after adjusting for TC, for all phases. CONCLUSION: These results indicate that a single dose of PS in low-fat yogurt, provided as a snack, lowers cholesterol levels but does not alter fat-soluble vitamin or carotenoid concentrations in hyperlipidemic participants. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/18845709/Cholesterol_lowering_efficacy_of_plant_sterols_in_low_fat_yogurt_consumed_as_a_snack_or_with_a_meal_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2008.10719742 DB - PRIME DP - Unbound Medicine ER -