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Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.
Neurochem Res. 2009 Apr; 34(4):755-63.NR

Abstract

To investigate the mitochondrial decay and oxidative damage resulting from aging, the activities/kinetics of the mitochondrial complexes were examined in the brains of young and old rats as well as in old rats fed R-alpha-lipoic acid plus acetyl-L-carnitine (LA/ALC). The brain mitochondria of old rats, compared with young rats, had significantly decreased endogenous antioxidants and superoxide dismutase activity; more oxidative damage to lipids and proteins; and decreased activities of complex I, IV and V. Complex I showed a decrease in binding affinity (increase in K(m)) for substrates. Feeding LA/ALC to old rats partially restored age-associated mitochondrial dysfunction to the levels of the young rats. These results indicate that oxidative mitochondrial decay plays an important role in brain aging and that a combination of nutrients targeting mitochondria, such as LA/ALC, could ameliorate mitochondrial decay through preventing mitochondrial oxidative damage.

Authors+Show Affiliations

Institute for Brain Aging and Dementia, University of California, Irvine, CA 92697-4540, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18846423

Citation

Long, Jiangang, et al. "Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-lipoic Acid and Acetyl-L-carnitine." Neurochemical Research, vol. 34, no. 4, 2009, pp. 755-63.
Long J, Gao F, Tong L, et al. Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res. 2009;34(4):755-63.
Long, J., Gao, F., Tong, L., Cotman, C. W., Ames, B. N., & Liu, J. (2009). Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochemical Research, 34(4), 755-63. https://doi.org/10.1007/s11064-008-9850-2
Long J, et al. Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-lipoic Acid and Acetyl-L-carnitine. Neurochem Res. 2009;34(4):755-63. PubMed PMID: 18846423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. AU - Long,Jiangang, AU - Gao,Feng, AU - Tong,Liqi, AU - Cotman,Carl W, AU - Ames,Bruce N, AU - Liu,Jiankang, Y1 - 2008/10/10/ PY - 2008/05/28/received PY - 2008/09/03/accepted PY - 2008/10/11/pubmed PY - 2009/6/6/medline PY - 2008/10/11/entrez SP - 755 EP - 63 JF - Neurochemical research JO - Neurochem Res VL - 34 IS - 4 N2 - To investigate the mitochondrial decay and oxidative damage resulting from aging, the activities/kinetics of the mitochondrial complexes were examined in the brains of young and old rats as well as in old rats fed R-alpha-lipoic acid plus acetyl-L-carnitine (LA/ALC). The brain mitochondria of old rats, compared with young rats, had significantly decreased endogenous antioxidants and superoxide dismutase activity; more oxidative damage to lipids and proteins; and decreased activities of complex I, IV and V. Complex I showed a decrease in binding affinity (increase in K(m)) for substrates. Feeding LA/ALC to old rats partially restored age-associated mitochondrial dysfunction to the levels of the young rats. These results indicate that oxidative mitochondrial decay plays an important role in brain aging and that a combination of nutrients targeting mitochondria, such as LA/ALC, could ameliorate mitochondrial decay through preventing mitochondrial oxidative damage. SN - 1573-6903 UR - https://www.unboundmedicine.com/medline/citation/18846423/Mitochondrial_decay_in_the_brains_of_old_rats:_ameliorating_effect_of_alpha_lipoic_acid_and_acetyl_L_carnitine_ L2 - https://doi.org/10.1007/s11064-008-9850-2 DB - PRIME DP - Unbound Medicine ER -