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[Clinico-pathological manifestations in interstitial lung diseases associated with polymyositis-dermatomyositis].
Zhonghua Jie He He Hu Xi Za Zhi. 2008 Apr; 31(4):250-4.ZJ

Abstract

OBJECTIVE

Polymyositis-dermatomyositis has been associated with various histological patterns of interstitial lung disease (ILD). This study was to investigate the clinico-pathologic features of interstitial lung diseases associated with polymyositis-dermatomyositis.

METHODS

We retrospectively identified 26 patients with polymyositis-dermatomyositis associated ILD who underwent lung biopsies (6 autopsies, 5 surgical lung biopsies and 15 percutaneous lung biopsies) at our hospital during a 27-year period from January 1980 through October 2007. Histopathologic findings were analyzed and correlated with radiological features and outcome.

RESULTS

Median age was 48 years (range, 19 to 65 years), and 16 patients were women. Chest X-ray imaging revealed bilateral infiltrates including ground-glass attenuation, patchy infiltration, and reticular opacities. The major histopathologic patterns included diffuse alveolar damage (DAD) (n = 5), lymphocytic interstitial pneumonia (n = 2), nonspecific interstitial pneumonia (NSIP) (cellular pattern, n = 6; mixed pattern, n = 8), organizing pneumonia (n = 4), usual interstitial pneumonia (UIP) (n = 1). Treatment commonly included prednisone with immunosuppressive agent. During the follow-up period (median, 15 month,range from 6 to 108 month), 18 patients improved or remained stable. Eight patients died, including 5 deaths from DAD, 2 from NSIP mixed pattern, 1 from UIP.

CONCLUSIONS

A variety of histological patterns can be seen in patients with polymyositis-dermatomyositis-associated ILD. Those with DAD tended to have poor prognosis.

Authors+Show Affiliations

Department of Respiratory Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

chi

PubMed ID

18846959

Citation

Shi, Ju-hong, et al. "[Clinico-pathological Manifestations in Interstitial Lung Diseases Associated With Polymyositis-dermatomyositis]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 31, no. 4, 2008, pp. 250-4.
Shi JH, Xu WB, Liu HR, et al. [Clinico-pathological manifestations in interstitial lung diseases associated with polymyositis-dermatomyositis]. Zhonghua Jie He He Hu Xi Za Zhi. 2008;31(4):250-4.
Shi, J. H., Xu, W. B., Liu, H. R., Tian, X. L., Feng, R. E., Xu, Z. J., & Zhu, Y. J. (2008). [Clinico-pathological manifestations in interstitial lung diseases associated with polymyositis-dermatomyositis]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 31(4), 250-4.
Shi JH, et al. [Clinico-pathological Manifestations in Interstitial Lung Diseases Associated With Polymyositis-dermatomyositis]. Zhonghua Jie He He Hu Xi Za Zhi. 2008;31(4):250-4. PubMed PMID: 18846959.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Clinico-pathological manifestations in interstitial lung diseases associated with polymyositis-dermatomyositis]. AU - Shi,Ju-hong, AU - Xu,Wen-bing, AU - Liu,Hong-rui, AU - Tian,Xin-lun, AU - Feng,Rui-e, AU - Xu,Zuo-jun, AU - Zhu,Yuan-jue, PY - 2008/10/14/pubmed PY - 2010/9/8/medline PY - 2008/10/14/entrez SP - 250 EP - 4 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 31 IS - 4 N2 - OBJECTIVE: Polymyositis-dermatomyositis has been associated with various histological patterns of interstitial lung disease (ILD). This study was to investigate the clinico-pathologic features of interstitial lung diseases associated with polymyositis-dermatomyositis. METHODS: We retrospectively identified 26 patients with polymyositis-dermatomyositis associated ILD who underwent lung biopsies (6 autopsies, 5 surgical lung biopsies and 15 percutaneous lung biopsies) at our hospital during a 27-year period from January 1980 through October 2007. Histopathologic findings were analyzed and correlated with radiological features and outcome. RESULTS: Median age was 48 years (range, 19 to 65 years), and 16 patients were women. Chest X-ray imaging revealed bilateral infiltrates including ground-glass attenuation, patchy infiltration, and reticular opacities. The major histopathologic patterns included diffuse alveolar damage (DAD) (n = 5), lymphocytic interstitial pneumonia (n = 2), nonspecific interstitial pneumonia (NSIP) (cellular pattern, n = 6; mixed pattern, n = 8), organizing pneumonia (n = 4), usual interstitial pneumonia (UIP) (n = 1). Treatment commonly included prednisone with immunosuppressive agent. During the follow-up period (median, 15 month,range from 6 to 108 month), 18 patients improved or remained stable. Eight patients died, including 5 deaths from DAD, 2 from NSIP mixed pattern, 1 from UIP. CONCLUSIONS: A variety of histological patterns can be seen in patients with polymyositis-dermatomyositis-associated ILD. Those with DAD tended to have poor prognosis. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/18846959/[Clinico_pathological_manifestations_in_interstitial_lung_diseases_associated_with_polymyositis_dermatomyositis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1001-0939&year=2008&vol=31&issue=4&fpage=250 DB - PRIME DP - Unbound Medicine ER -