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Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy.
J Infect Dis. 2008 Nov 15; 198(10):1466-73.JI

Abstract

BACKGROUND

Factors influencing the depletion of CD4(+) cells and the restoration of CD4(+) cells after antiretroviral therapy are not completely understood. Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127). We analyzed the influence of T cell activation and of suppression of viremia with antiretroviral therapy on this system, as well as its role in CD4(+) cell restoration after long-term antiretroviral therapy.

METHODS

IL-7 levels and CD127 expression on several subsets of CD4(+) and CD8(+) T lymphocytes and the activation status (CD38) of these cells were examined at baseline and during 24 months of complete viral suppression under highly active antiretroviral therapy (HAART).

RESULTS

A total of 42 individuals with human immunodeficiency virus (HIV) infection and 10 age-matched, uninfected control subjects were examined. Before HAART, IL-7 levels were increased and CD127 expression was decreased. Down-regulation of CD127 was mainly associated with T cell activation and reverted only partially after suppression of detectable plasma HIV RNA with HAART. In a multivariate analysis, CD127 expression on CD8(+) T cells was the main determinant of the extent of CD4(+) cell gains after successful HAART.

CONCLUSIONS

The IL-7-CD127 system is impaired in HIV-infected patients. CD127 down-regulation is associated with T cell activation and with CD4(+) cell restoration after HAART.

Authors+Show Affiliations

Department of Infectious Diseases, Hospital Carlos III, Madrid, Spain. jbenito@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18847371

Citation

Benito, José M., et al. "Down-regulation of Interleukin-7 Receptor (CD127) in HIV Infection Is Associated With T Cell Activation and Is a Main Factor Influencing Restoration of CD4(+) Cells After Antiretroviral Therapy." The Journal of Infectious Diseases, vol. 198, no. 10, 2008, pp. 1466-73.
Benito JM, López M, Lozano S, et al. Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy. J Infect Dis. 2008;198(10):1466-73.
Benito, J. M., López, M., Lozano, S., González-Lahoz, J., & Soriano, V. (2008). Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy. The Journal of Infectious Diseases, 198(10), 1466-73. https://doi.org/10.1086/592716
Benito JM, et al. Down-regulation of Interleukin-7 Receptor (CD127) in HIV Infection Is Associated With T Cell Activation and Is a Main Factor Influencing Restoration of CD4(+) Cells After Antiretroviral Therapy. J Infect Dis. 2008 Nov 15;198(10):1466-73. PubMed PMID: 18847371.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down-regulation of interleukin-7 receptor (CD127) in HIV infection is associated with T cell activation and is a main factor influencing restoration of CD4(+) cells after antiretroviral therapy. AU - Benito,José M, AU - López,Mariola, AU - Lozano,Sara, AU - González-Lahoz,Juan, AU - Soriano,Vincent, PY - 2008/10/14/pubmed PY - 2009/1/7/medline PY - 2008/10/14/entrez SP - 1466 EP - 73 JF - The Journal of infectious diseases JO - J Infect Dis VL - 198 IS - 10 N2 - BACKGROUND: Factors influencing the depletion of CD4(+) cells and the restoration of CD4(+) cells after antiretroviral therapy are not completely understood. Recently, attention has been paid to interleukin (IL)-7 and its receptor (CD127). We analyzed the influence of T cell activation and of suppression of viremia with antiretroviral therapy on this system, as well as its role in CD4(+) cell restoration after long-term antiretroviral therapy. METHODS: IL-7 levels and CD127 expression on several subsets of CD4(+) and CD8(+) T lymphocytes and the activation status (CD38) of these cells were examined at baseline and during 24 months of complete viral suppression under highly active antiretroviral therapy (HAART). RESULTS: A total of 42 individuals with human immunodeficiency virus (HIV) infection and 10 age-matched, uninfected control subjects were examined. Before HAART, IL-7 levels were increased and CD127 expression was decreased. Down-regulation of CD127 was mainly associated with T cell activation and reverted only partially after suppression of detectable plasma HIV RNA with HAART. In a multivariate analysis, CD127 expression on CD8(+) T cells was the main determinant of the extent of CD4(+) cell gains after successful HAART. CONCLUSIONS: The IL-7-CD127 system is impaired in HIV-infected patients. CD127 down-regulation is associated with T cell activation and with CD4(+) cell restoration after HAART. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/18847371/Down_regulation_of_interleukin_7_receptor__CD127__in_HIV_infection_is_associated_with_T_cell_activation_and_is_a_main_factor_influencing_restoration_of_CD4_+__cells_after_antiretroviral_therapy_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/592716 DB - PRIME DP - Unbound Medicine ER -