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Plasma visfatin levels in normal weight women with polycystic ovary syndrome.
Eur J Intern Med. 2008 Oct; 19(6):406-12.EJ

Abstract

BACKGROUND

The present study was designed to measure plasma visfatin levels in normal weight women with polycystic ovary syndrome (PCOS) and to assess possible correlations between visfatin and the hormonal or metabolic parameters of the syndrome.

METHODS

Twenty-five normal weight [body mass index (BMI)<25 kg/m(2)] women with PCOS, 24 obese and overweight (BMI>25 kg/m(2)) controls (ovulating women without clinical or biochemical hyperandrogenism), and 24 normal weight controls were studied. Blood samples were collected between the 3rd and the 7th days of a menstrual cycle in the control groups and during a spontaneous bleeding episode in the PCOS groups at 9:00 A.M., after an overnight fast. Circulating levels of LH, FSH, prolactin (PRL), testosterone (T), Delta(4)-androstenedione (Delta(4)-Alpha), dehydroepiandrosterone sulfate (DHEA-S), 17alpha-OH-progesterone (17OH-P), sex hormone-binding globulin (SHBG), insulin, glucose, and visfatin were measured.

RESULTS

Plasma visfatin levels and the visfatin-to-insulin ratio were significantly lower in normal weight controls than in both normal weight women with PCOS and overweight or obese controls. The visfatin-to-insulin ratio was significantly higher in normal weight women with PCOS than in overweight or obese controls. Plasma visfatin levels were found to be positively correlated with LH and Delta(4)A levels, as well as with free androgen index (FAI) values, and negatively correlated with SHBG. LH and SHBG levels were found to be the only independent significant determinants of circulating visfatin. In the control groups, plasma visfatin levels were significantly correlated with BMI, waist (W) measurement, and waist-to-hip ratio (WHR).

CONCLUSIONS

Visfatin levels are positively associated with obesity in healthy women of reproductive age. Moreover, the present study indicates, for the first time, a possible involvement of increased visfatin levels in PCOS-associated metabolic and hormonal disturbances.

Authors+Show Affiliations

Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18848173

Citation

Panidis, Dimitrios, et al. "Plasma Visfatin Levels in Normal Weight Women With Polycystic Ovary Syndrome." European Journal of Internal Medicine, vol. 19, no. 6, 2008, pp. 406-12.
Panidis D, Farmakiotis D, Rousso D, et al. Plasma visfatin levels in normal weight women with polycystic ovary syndrome. Eur J Intern Med. 2008;19(6):406-12.
Panidis, D., Farmakiotis, D., Rousso, D., Katsikis, I., Delkos, D., Piouka, A., Gerou, S., & Diamanti-Kandarakis, E. (2008). Plasma visfatin levels in normal weight women with polycystic ovary syndrome. European Journal of Internal Medicine, 19(6), 406-12. https://doi.org/10.1016/j.ejim.2007.05.014
Panidis D, et al. Plasma Visfatin Levels in Normal Weight Women With Polycystic Ovary Syndrome. Eur J Intern Med. 2008;19(6):406-12. PubMed PMID: 18848173.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma visfatin levels in normal weight women with polycystic ovary syndrome. AU - Panidis,Dimitrios, AU - Farmakiotis,Dimitrios, AU - Rousso,David, AU - Katsikis,Ilias, AU - Delkos,Dimitrios, AU - Piouka,Athanasia, AU - Gerou,Spiros, AU - Diamanti-Kandarakis,Evanthia, Y1 - 2008/01/30/ PY - 2006/11/28/received PY - 2007/04/22/revised PY - 2007/05/06/accepted PY - 2008/10/14/pubmed PY - 2009/2/4/medline PY - 2008/10/14/entrez SP - 406 EP - 12 JF - European journal of internal medicine JO - Eur. J. Intern. Med. VL - 19 IS - 6 N2 - BACKGROUND: The present study was designed to measure plasma visfatin levels in normal weight women with polycystic ovary syndrome (PCOS) and to assess possible correlations between visfatin and the hormonal or metabolic parameters of the syndrome. METHODS: Twenty-five normal weight [body mass index (BMI)<25 kg/m(2)] women with PCOS, 24 obese and overweight (BMI>25 kg/m(2)) controls (ovulating women without clinical or biochemical hyperandrogenism), and 24 normal weight controls were studied. Blood samples were collected between the 3rd and the 7th days of a menstrual cycle in the control groups and during a spontaneous bleeding episode in the PCOS groups at 9:00 A.M., after an overnight fast. Circulating levels of LH, FSH, prolactin (PRL), testosterone (T), Delta(4)-androstenedione (Delta(4)-Alpha), dehydroepiandrosterone sulfate (DHEA-S), 17alpha-OH-progesterone (17OH-P), sex hormone-binding globulin (SHBG), insulin, glucose, and visfatin were measured. RESULTS: Plasma visfatin levels and the visfatin-to-insulin ratio were significantly lower in normal weight controls than in both normal weight women with PCOS and overweight or obese controls. The visfatin-to-insulin ratio was significantly higher in normal weight women with PCOS than in overweight or obese controls. Plasma visfatin levels were found to be positively correlated with LH and Delta(4)A levels, as well as with free androgen index (FAI) values, and negatively correlated with SHBG. LH and SHBG levels were found to be the only independent significant determinants of circulating visfatin. In the control groups, plasma visfatin levels were significantly correlated with BMI, waist (W) measurement, and waist-to-hip ratio (WHR). CONCLUSIONS: Visfatin levels are positively associated with obesity in healthy women of reproductive age. Moreover, the present study indicates, for the first time, a possible involvement of increased visfatin levels in PCOS-associated metabolic and hormonal disturbances. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/18848173/Plasma_visfatin_levels_in_normal_weight_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(07)00380-9 DB - PRIME DP - Unbound Medicine ER -