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Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR.
Am J Prev Med. 2008 Dec; 35(6):554-60.AJ

Abstract

BACKGROUND

There is a shortage of longitudinal data analyzing associations between physical activity and indicators of insulin resistance among children and adolescents after accounting for adiposity change. To guide future prevention efforts, data were used from the Danish arm of the European Youth Heart Study to examine these issues.

METHODS

Participants were 384 students in Grade 9 (aged 15 years) from the municipality of Odense, Denmark, who participated in surveys in 1997 and 2003. Physical activity was monitored for at least 3 days by accelerometer, and mean counts per minute (CPM) and minutes >3000 CPM per day were obtained. Blood samples were collected, and levels of fasting insulin, fasting glucose, and homeostasis model of assessment of insulin resistance (HOMA-IR) were obtained. Data were analyzed in 2008.

RESULTS

Physical activity declined from 45 minutes >3000 CPM in 1997 to 35 minutes >3000 CPM in 2003. Longitudinal regression analyses showed that a change in minutes >3000 CPM was negatively associated with fasting insulin levels (z=-2.47, p=0.014) and HOMA-IR (z=-2.31, p=0.021) in 2003. Similar findings were found when CPM was used as the physical activity variable. Results demonstrated that a 6-year decline in physical activity was associated with higher insulin and HOMA-IR levels.

CONCLUSIONS

The 6-year change in the volume of physical activity engaged in by adolescents aged 15 years was negatively associated with fasting insulin and HOMA-IR. Preventing an age-related decline in physical activity may be an effective means of preventing youth insulin resistance.

Authors+Show Affiliations

Department of Exercise, Nutrition and Health Sciences, University of Bristol, Bristol, England. Russ.Jago@bris.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18848414

Citation

Jago, Russell, et al. "Six-year Change in Youth Physical Activity and Effect On Fasting Insulin and HOMA-IR." American Journal of Preventive Medicine, vol. 35, no. 6, 2008, pp. 554-60.
Jago R, Wedderkopp N, Kristensen PL, et al. Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR. Am J Prev Med. 2008;35(6):554-60.
Jago, R., Wedderkopp, N., Kristensen, P. L., Møller, N. C., Andersen, L. B., Cooper, A. R., & Froberg, K. (2008). Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR. American Journal of Preventive Medicine, 35(6), 554-60. https://doi.org/10.1016/j.amepre.2008.07.007
Jago R, et al. Six-year Change in Youth Physical Activity and Effect On Fasting Insulin and HOMA-IR. Am J Prev Med. 2008;35(6):554-60. PubMed PMID: 18848414.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Six-year change in youth physical activity and effect on fasting insulin and HOMA-IR. AU - Jago,Russell, AU - Wedderkopp,Niels, AU - Kristensen,Peter L, AU - Møller,Niels C, AU - Andersen,Lars B, AU - Cooper,Ashley R, AU - Froberg,Karsten, Y1 - 2008/10/09/ PY - 2008/02/05/received PY - 2008/05/20/revised PY - 2008/07/31/accepted PY - 2008/10/14/pubmed PY - 2009/1/1/medline PY - 2008/10/14/entrez SP - 554 EP - 60 JF - American journal of preventive medicine JO - Am J Prev Med VL - 35 IS - 6 N2 - BACKGROUND: There is a shortage of longitudinal data analyzing associations between physical activity and indicators of insulin resistance among children and adolescents after accounting for adiposity change. To guide future prevention efforts, data were used from the Danish arm of the European Youth Heart Study to examine these issues. METHODS: Participants were 384 students in Grade 9 (aged 15 years) from the municipality of Odense, Denmark, who participated in surveys in 1997 and 2003. Physical activity was monitored for at least 3 days by accelerometer, and mean counts per minute (CPM) and minutes >3000 CPM per day were obtained. Blood samples were collected, and levels of fasting insulin, fasting glucose, and homeostasis model of assessment of insulin resistance (HOMA-IR) were obtained. Data were analyzed in 2008. RESULTS: Physical activity declined from 45 minutes >3000 CPM in 1997 to 35 minutes >3000 CPM in 2003. Longitudinal regression analyses showed that a change in minutes >3000 CPM was negatively associated with fasting insulin levels (z=-2.47, p=0.014) and HOMA-IR (z=-2.31, p=0.021) in 2003. Similar findings were found when CPM was used as the physical activity variable. Results demonstrated that a 6-year decline in physical activity was associated with higher insulin and HOMA-IR levels. CONCLUSIONS: The 6-year change in the volume of physical activity engaged in by adolescents aged 15 years was negatively associated with fasting insulin and HOMA-IR. Preventing an age-related decline in physical activity may be an effective means of preventing youth insulin resistance. SN - 1873-2607 UR - https://www.unboundmedicine.com/medline/citation/18848414/Six_year_change_in_youth_physical_activity_and_effect_on_fasting_insulin_and_HOMA_IR_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0749-3797(08)00735-6 DB - PRIME DP - Unbound Medicine ER -