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EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls.
Clin Neurophysiol. 2008 Dec; 119(12):2727-32.CN

Abstract

OBJECTIVE

We examined the relation between Apolipoprotein E epsilon4 allele (ApoE epsilon4) genotype and functional connectivity measured by Electroencephalography (EEG) in patients with Alzheimer's disease (AD) and patients with subjective complaints (SC).

METHODS

We included 43 patients with AD (age (SD)=74.2 (4.0), m/f=22/21; 30 of ApoE epsilon4 carriers) and 21 patients with SC (age (SD)=73.2 (5.2), m/f=13/8; 7 ApoE epsilon4 carriers) for this study. Resting state EEGs were recorded in all subjects. Synchronisation likelihood (SL) between local cortical areas was compared in the alpha and beta band according to ApoE epsilon4 status and diagnosis.

RESULTS

ApoE epsilon4 carriers had higher SL values in lower and upper alpha band, in both diagnostic groups. In upper alpha band and beta band AD patients had lower SL than patients with SC, was irrespective of ApoE status.

CONCLUSION

The effects of AD and ApoE epsilon4 on functional connectivity are opposite and independent.

SIGNIFICANCE

The observed increase in SL in both AD and patients with SC carrying ApoE epsilon4 suggests a strong genetic impact of ApoE epsilon4 on brain function.

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Authors+Show Affiliations

Kramer G
Department of Neurology, Alzheimer Centre, VU University Medical Center, PO Box 7057, De Boelelaan 1118, 1007 MB Amsterdam, Noord Holland, The Netherlands.
van der Flier WM
No affiliation info available
de Langen C
No affiliation info available
Blankenstein MA
No affiliation info available
Scheltens P
No affiliation info available
Stam CJ
No affiliation info available

MeSH

AgedAlzheimer DiseaseAnalysis of VarianceApolipoproteins EBrainCognition DisordersElectroencephalographyFemaleGenotypeHumansLikelihood FunctionsLinear ModelsMaleMental Status ScheduleNeuropsychological TestsNumerical Analysis, Computer-AssistedRest

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18848805

Citation

Kramer, Gerdien, et al. "EEG Functional Connectivity and ApoE Genotype in Alzheimer's Disease and Controls." Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, vol. 119, no. 12, 2008, pp. 2727-32.
Kramer G, van der Flier WM, de Langen C, et al. EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls. Clin Neurophysiol. 2008;119(12):2727-32.
Kramer, G., van der Flier, W. M., de Langen, C., Blankenstein, M. A., Scheltens, P., & Stam, C. J. (2008). EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls. Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology, 119(12), 2727-32. https://doi.org/10.1016/j.clinph.2008.08.019
Kramer G, et al. EEG Functional Connectivity and ApoE Genotype in Alzheimer's Disease and Controls. Clin Neurophysiol. 2008;119(12):2727-32. PubMed PMID: 18848805.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EEG functional connectivity and ApoE genotype in Alzheimer's disease and controls. AU - Kramer,Gerdien, AU - van der Flier,Wiesje M, AU - de Langen,Conny, AU - Blankenstein,Marinus A, AU - Scheltens,Philip, AU - Stam,Cornelis J, Y1 - 2008/10/10/ PY - 2007/10/05/received PY - 2008/08/18/revised PY - 2008/08/23/accepted PY - 2008/10/14/pubmed PY - 2009/4/9/medline PY - 2008/10/14/entrez SP - 2727 EP - 32 JF - Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology JO - Clin Neurophysiol VL - 119 IS - 12 N2 - OBJECTIVE: We examined the relation between Apolipoprotein E epsilon4 allele (ApoE epsilon4) genotype and functional connectivity measured by Electroencephalography (EEG) in patients with Alzheimer's disease (AD) and patients with subjective complaints (SC). METHODS: We included 43 patients with AD (age (SD)=74.2 (4.0), m/f=22/21; 30 of ApoE epsilon4 carriers) and 21 patients with SC (age (SD)=73.2 (5.2), m/f=13/8; 7 ApoE epsilon4 carriers) for this study. Resting state EEGs were recorded in all subjects. Synchronisation likelihood (SL) between local cortical areas was compared in the alpha and beta band according to ApoE epsilon4 status and diagnosis. RESULTS: ApoE epsilon4 carriers had higher SL values in lower and upper alpha band, in both diagnostic groups. In upper alpha band and beta band AD patients had lower SL than patients with SC, was irrespective of ApoE status. CONCLUSION: The effects of AD and ApoE epsilon4 on functional connectivity are opposite and independent. SIGNIFICANCE: The observed increase in SL in both AD and patients with SC carrying ApoE epsilon4 suggests a strong genetic impact of ApoE epsilon4 on brain function. SN - 1872-8952 UR - https://www.unboundmedicine.com/medline/citation/18848805/EEG_functional_connectivity_and_ApoE_genotype_in_Alzheimer's_disease_and_controls_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1388-2457(08)00928-0 DB - PRIME DP - Unbound Medicine ER -