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Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus.
Eur J Endocrinol. 2009 Jan; 160(1):33-8.EJ

Abstract

OBJECTIVE

Adipocyte fatty acid binding protein (AFABP) was recently introduced as a novel adipokine, serum levels of which independently correlate with the development of the metabolic syndrome and cardiovascular disease in humans. In the current study, we investigated serum concentrations of AFABP in patients with gestational diabetes mellitus (GDM) as compared with healthy pregnant controls matched for gestational age and fasting insulin.

DESIGN AND METHODS

AFABP was determined by ELISA in controls (n=80) and GDM patients (n=40) and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation, in both groups.

RESULTS

Median serum AFABP concentrations were significantly elevated in subjects with GDM (22.9 microg/l) as compared with healthy pregnant controls (18.3 microg/l; P<0.05). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis (P<0.05). In addition, markers of adiposity (body mass index, serum leptin), triglycerides and serum creatinine were independently associated with circulating AFABP (P<0.05).

CONCLUSIONS

Maternal AFABP concentrations are significantly increased in GDM. The adipokine might contribute to the increased metabolic and cardiovascular risk of the disease.

Authors+Show Affiliations

Department of Internal Medicine III, University of Leipzig, Leipzig, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18849305

Citation

Kralisch, Susan, et al. "Serum Levels of Adipocyte Fatty Acid Binding Protein Are Increased in Gestational Diabetes Mellitus." European Journal of Endocrinology, vol. 160, no. 1, 2009, pp. 33-8.
Kralisch S, Stepan H, Kratzsch J, et al. Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus. Eur J Endocrinol. 2009;160(1):33-8.
Kralisch, S., Stepan, H., Kratzsch, J., Verlohren, M., Verlohren, H. J., Drynda, K., Lössner, U., Blüher, M., Stumvoll, M., & Fasshauer, M. (2009). Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus. European Journal of Endocrinology, 160(1), 33-8. https://doi.org/10.1530/EJE-08-0540
Kralisch S, et al. Serum Levels of Adipocyte Fatty Acid Binding Protein Are Increased in Gestational Diabetes Mellitus. Eur J Endocrinol. 2009;160(1):33-8. PubMed PMID: 18849305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum levels of adipocyte fatty acid binding protein are increased in gestational diabetes mellitus. AU - Kralisch,Susan, AU - Stepan,Holger, AU - Kratzsch,Jürgen, AU - Verlohren,Michael, AU - Verlohren,Hans-Joachim, AU - Drynda,Kathrin, AU - Lössner,Ulrike, AU - Blüher,Matthias, AU - Stumvoll,Michael, AU - Fasshauer,Mathias, Y1 - 2008/10/10/ PY - 2008/10/14/entrez PY - 2008/10/14/pubmed PY - 2009/1/16/medline SP - 33 EP - 8 JF - European journal of endocrinology JO - Eur. J. Endocrinol. VL - 160 IS - 1 N2 - OBJECTIVE: Adipocyte fatty acid binding protein (AFABP) was recently introduced as a novel adipokine, serum levels of which independently correlate with the development of the metabolic syndrome and cardiovascular disease in humans. In the current study, we investigated serum concentrations of AFABP in patients with gestational diabetes mellitus (GDM) as compared with healthy pregnant controls matched for gestational age and fasting insulin. DESIGN AND METHODS: AFABP was determined by ELISA in controls (n=80) and GDM patients (n=40) and correlated to clinical and biochemical measures of renal function, glucose and lipid metabolism, as well as inflammation, in both groups. RESULTS: Median serum AFABP concentrations were significantly elevated in subjects with GDM (22.9 microg/l) as compared with healthy pregnant controls (18.3 microg/l; P<0.05). Furthermore, GDM was independently associated with AFABP concentrations in multiple regression analysis (P<0.05). In addition, markers of adiposity (body mass index, serum leptin), triglycerides and serum creatinine were independently associated with circulating AFABP (P<0.05). CONCLUSIONS: Maternal AFABP concentrations are significantly increased in GDM. The adipokine might contribute to the increased metabolic and cardiovascular risk of the disease. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/18849305/Serum_levels_of_adipocyte_fatty_acid_binding_protein_are_increased_in_gestational_diabetes_mellitus_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-08-0540 DB - PRIME DP - Unbound Medicine ER -