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Characteristics of thiamin and its relevance to the management of heart failure.
Nutr Clin Pract. 2008 Oct-Nov; 23(5):487-93.NC

Abstract

Heart failure (HF) is a major public health problem in the United States that puts a significant burden on both patients and the healthcare system. The prevalence of malnutrition in HF patients is well-known and correlates with a dramatic decline in quality of life and disease progression, and is associated with high morbidity and mortality rates. The implication of HF on micronutrient status is underrecognized in the quest to offer "best practice" medical, device, and surgical interventions to this population. The micronutrient thiamin is of particular interest in the management of HF for several reasons: (a) HF is a disease of the elderly whose micronutrient status is in need of attention; (b) HF patients tend to have inadequate nutrient intake, which has been associated with thiamin deficiency; (c) thiamin deficiency (wet beriberi) impairs cardiac performance and can mimic the signs and symptoms of HF thereby potentially exacerbating the underlying disease; (d) use of loop diuretics to manage fluid and sodium imbalances associated with HF may cause the hyperexcretion of thiamin, thereby increasing the risk of deficiency; and (e) the prevention of thiamin deficiency should be a routine component in the overall management of this disease.

Authors+Show Affiliations

University of Michigan Health System, Ann Arbor, MI, USA. jenwoole@med.umich.edu

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18849553

Citation

Wooley, Jennifer A.. "Characteristics of Thiamin and Its Relevance to the Management of Heart Failure." Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, vol. 23, no. 5, 2008, pp. 487-93.
Wooley JA. Characteristics of thiamin and its relevance to the management of heart failure. Nutr Clin Pract. 2008;23(5):487-93.
Wooley, J. A. (2008). Characteristics of thiamin and its relevance to the management of heart failure. Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition, 23(5), 487-93. https://doi.org/10.1177/0884533608323430
Wooley JA. Characteristics of Thiamin and Its Relevance to the Management of Heart Failure. Nutr Clin Pract. 2008 Oct-Nov;23(5):487-93. PubMed PMID: 18849553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of thiamin and its relevance to the management of heart failure. A1 - Wooley,Jennifer A, PY - 2008/10/14/pubmed PY - 2008/11/14/medline PY - 2008/10/14/entrez SP - 487 EP - 93 JF - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JO - Nutr Clin Pract VL - 23 IS - 5 N2 - Heart failure (HF) is a major public health problem in the United States that puts a significant burden on both patients and the healthcare system. The prevalence of malnutrition in HF patients is well-known and correlates with a dramatic decline in quality of life and disease progression, and is associated with high morbidity and mortality rates. The implication of HF on micronutrient status is underrecognized in the quest to offer "best practice" medical, device, and surgical interventions to this population. The micronutrient thiamin is of particular interest in the management of HF for several reasons: (a) HF is a disease of the elderly whose micronutrient status is in need of attention; (b) HF patients tend to have inadequate nutrient intake, which has been associated with thiamin deficiency; (c) thiamin deficiency (wet beriberi) impairs cardiac performance and can mimic the signs and symptoms of HF thereby potentially exacerbating the underlying disease; (d) use of loop diuretics to manage fluid and sodium imbalances associated with HF may cause the hyperexcretion of thiamin, thereby increasing the risk of deficiency; and (e) the prevention of thiamin deficiency should be a routine component in the overall management of this disease. SN - 0884-5336 UR - https://www.unboundmedicine.com/medline/citation/18849553/Characteristics_of_thiamin_and_its_relevance_to_the_management_of_heart_failure_ L2 - https://doi.org/10.1177/0884533608323430 DB - PRIME DP - Unbound Medicine ER -