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Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats.
Methods Find Exp Clin Pharmacol. 2008 Jul-Aug; 30(6):431-41.MF

Abstract

Anticonvulsants, including gabapentin and carbamazepine, have shown activity against several types of neuropathic pain; however, they have limiting side effects that may minimize their use. In this study the possible synergistic interaction between anticonvulsants and benfotiamine or cyanocobalamin on spinal nerve ligation-induced tactile allodynia was assessed. Oral administration of gabapentin (15-300 mg/kg), carbamazepine (10-300 mg/kg), benfotiamine (30-600 mg/kg) or cyanocobalamin (0.3-6.0 mg/kg) significantly reduced tactile allodynia in rats. Maximal antiallodynic effects were reached with gabapentin 300 mg/kg (approximately 70%), carbamazepine 300 mg/kg (approximately 66%), benfotiamine 600 mg/kg (approximately 51%) and cyanocobalamin 6 mg/kg (approximately 59%). At the highest tested doses, gabapentin, but not carbamazepine, benfotiamine or cyanocobalamin, significantly reduced motor coordination. Coadministration of gabapentin or carbamazepine with benfotiamine or cyanocobalamin in a fixed ratio markedly reduced spinal nerve ligation-induced tactile allodynia, showing a synergistic interaction between anticonvulsants and B vitamins. Data indicate that combinations of anticonvulsants with benfotiamine or cyanocobalamin are able to reduce tactile allodynia without affecting motor coordination in rats, and suggest the possible clinical use of these combinations in the treatment of neuropathic pain in humans.

Authors+Show Affiliations

Centro de Investigacion y de Estudios Avanzados, Unidad Monterrey, Apodaca, Nuevo Leon, Mexico.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18850044

Citation

Mixcoatl-Zecuatl, Teresa, et al. "Synergistic Antiallodynic Interaction Between Gabapentin or Carbamazepine and Either Benfotiamine or Cyanocobalamin in Neuropathic Rats." Methods and Findings in Experimental and Clinical Pharmacology, vol. 30, no. 6, 2008, pp. 431-41.
Mixcoatl-Zecuatl T, Quinonez-Bastidas GN, Caram-Salas NL, et al. Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. Methods Find Exp Clin Pharmacol. 2008;30(6):431-41.
Mixcoatl-Zecuatl, T., Quinonez-Bastidas, G. N., Caram-Salas, N. L., Ambriz-Tututi, M., Araiza-Saldana, C. I., Rocha-Gonzalez, H. I., Medina-Santillan, R., Reyes-Garcia, G., & Granados-Soto, V. (2008). Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. Methods and Findings in Experimental and Clinical Pharmacology, 30(6), 431-41. https://doi.org/10.1358/mf.2008.30.6.1232963
Mixcoatl-Zecuatl T, et al. Synergistic Antiallodynic Interaction Between Gabapentin or Carbamazepine and Either Benfotiamine or Cyanocobalamin in Neuropathic Rats. Methods Find Exp Clin Pharmacol. 2008 Jul-Aug;30(6):431-41. PubMed PMID: 18850044.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synergistic antiallodynic interaction between gabapentin or carbamazepine and either benfotiamine or cyanocobalamin in neuropathic rats. AU - Mixcoatl-Zecuatl,Teresa, AU - Quinonez-Bastidas,Geovanna N, AU - Caram-Salas,Nadia L, AU - Ambriz-Tututi,Monica, AU - Araiza-Saldana,Claudia I, AU - Rocha-Gonzalez,Hector I, AU - Medina-Santillan,Roberto, AU - Reyes-Garcia,Gerardo, AU - Granados-Soto,Vinicio, PY - 2008/10/14/pubmed PY - 2008/12/17/medline PY - 2008/10/14/entrez SP - 431 EP - 41 JF - Methods and findings in experimental and clinical pharmacology JO - Methods Find Exp Clin Pharmacol VL - 30 IS - 6 N2 - Anticonvulsants, including gabapentin and carbamazepine, have shown activity against several types of neuropathic pain; however, they have limiting side effects that may minimize their use. In this study the possible synergistic interaction between anticonvulsants and benfotiamine or cyanocobalamin on spinal nerve ligation-induced tactile allodynia was assessed. Oral administration of gabapentin (15-300 mg/kg), carbamazepine (10-300 mg/kg), benfotiamine (30-600 mg/kg) or cyanocobalamin (0.3-6.0 mg/kg) significantly reduced tactile allodynia in rats. Maximal antiallodynic effects were reached with gabapentin 300 mg/kg (approximately 70%), carbamazepine 300 mg/kg (approximately 66%), benfotiamine 600 mg/kg (approximately 51%) and cyanocobalamin 6 mg/kg (approximately 59%). At the highest tested doses, gabapentin, but not carbamazepine, benfotiamine or cyanocobalamin, significantly reduced motor coordination. Coadministration of gabapentin or carbamazepine with benfotiamine or cyanocobalamin in a fixed ratio markedly reduced spinal nerve ligation-induced tactile allodynia, showing a synergistic interaction between anticonvulsants and B vitamins. Data indicate that combinations of anticonvulsants with benfotiamine or cyanocobalamin are able to reduce tactile allodynia without affecting motor coordination in rats, and suggest the possible clinical use of these combinations in the treatment of neuropathic pain in humans. SN - 0379-0355 UR - https://www.unboundmedicine.com/medline/citation/18850044/Synergistic_antiallodynic_interaction_between_gabapentin_or_carbamazepine_and_either_benfotiamine_or_cyanocobalamin_in_neuropathic_rats_ L2 - http://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summaryn_pr?p_JournalId=6&p_RefId=1232963 DB - PRIME DP - Unbound Medicine ER -