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Body fat composition and distribution in women with polycystic ovary syndrome.

Abstract

OBJECTIVES

The aims of the present study were to compare the distribution and accumulation of body fat in women with polycystic ovary syndrome (PCOS) and healthy controls matched for age and body mass index (BMI), and to investigate the association between androgen levels, insulin resistance and fat distribution.

MATERIALS AND METHODS

Thirty-one PCOS women and 29 age- and BMI-matched healthy control women were evaluated in terms of subcutaneous adipose tissue thickness determined with a skinfold caliper and body composition analyzed by bioelectrical impedance analysis. Blood samples were obtained for determination of follicle-stimulating hormone, luteinizing hormone, 17beta-estradiol, 17-hydroxyprogesterone, basal prolactin, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG), androstenedione, insulin and glucose levels. Insulin sensitivity was estimated by fasting glucose/insulin ratio and free androgen index (FAI) was calculated as 100 x testosterone/SHBG. Differences between means were analyzed by Student's t test or the Mann-Whitney U test according to distribution of the data. Correlation analysis was performed between the body fat distribution and parameters concerning insulin resistance and androgens.

RESULTS

FAI was significantly higher in patients with PCOS compared with the control group (p = 0.001). Fasting insulin was significantly higher and fasting glucose/insulin ratio was significantly lower in the PCOS group vs. controls (p = 0.03 and 0.001, respectively). There was significantly less subcutaneous adipose tissue in the controls than the PCOS women at the triceps (p = 0.04) and subscapular region (p = 0.04). Waist-to-hip ratio of PCOS women was significantly higher than that of control subjects (p = 0.04).

CONCLUSION

Upper-half type body fat distribution is linked with PCOS, high free testosterone levels and insulin resistance.

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  • Authors+Show Affiliations

    ,

    Department of Obstetrics and Gynecology, Afyon Kocatepe University, Medical Faculty, Afyonkarahisar, Turkey. dremineay@hotmail.com

    , , , , ,

    Source

    MeSH

    Adipose Tissue
    Adult
    Androgens
    Blood Glucose
    Body Constitution
    Body Fat Distribution
    Body Mass Index
    Case-Control Studies
    Fasting
    Female
    Humans
    Insulin
    Insulin Resistance
    Polycystic Ovary Syndrome
    Skinfold Thickness
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    18850379

    Citation

    Cosar, Emine, et al. "Body Fat Composition and Distribution in Women With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 24, no. 8, 2008, pp. 428-32.
    Cosar E, Uçok K, Akgün L, et al. Body fat composition and distribution in women with polycystic ovary syndrome. Gynecol Endocrinol. 2008;24(8):428-32.
    Cosar, E., Uçok, K., Akgün, L., Köken, G., Sahin, F. K., Arioz, D. T., & Baş, O. (2008). Body fat composition and distribution in women with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 24(8), pp. 428-32. doi:10.1080/09513590802234253.
    Cosar E, et al. Body Fat Composition and Distribution in Women With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2008;24(8):428-32. PubMed PMID: 18850379.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Body fat composition and distribution in women with polycystic ovary syndrome. AU - Cosar,Emine, AU - Uçok,Kağan, AU - Akgün,Lütfi, AU - Köken,Gülengül, AU - Sahin,Figen Kir, AU - Arioz,Dagistan Tolga, AU - Baş,Orhan, PY - 2008/10/14/pubmed PY - 2009/1/29/medline PY - 2008/10/14/entrez SP - 428 EP - 32 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 24 IS - 8 N2 - OBJECTIVES: The aims of the present study were to compare the distribution and accumulation of body fat in women with polycystic ovary syndrome (PCOS) and healthy controls matched for age and body mass index (BMI), and to investigate the association between androgen levels, insulin resistance and fat distribution. MATERIALS AND METHODS: Thirty-one PCOS women and 29 age- and BMI-matched healthy control women were evaluated in terms of subcutaneous adipose tissue thickness determined with a skinfold caliper and body composition analyzed by bioelectrical impedance analysis. Blood samples were obtained for determination of follicle-stimulating hormone, luteinizing hormone, 17beta-estradiol, 17-hydroxyprogesterone, basal prolactin, testosterone, dehydroepiandrosterone sulfate, sex hormone-binding globulin (SHBG), androstenedione, insulin and glucose levels. Insulin sensitivity was estimated by fasting glucose/insulin ratio and free androgen index (FAI) was calculated as 100 x testosterone/SHBG. Differences between means were analyzed by Student's t test or the Mann-Whitney U test according to distribution of the data. Correlation analysis was performed between the body fat distribution and parameters concerning insulin resistance and androgens. RESULTS: FAI was significantly higher in patients with PCOS compared with the control group (p = 0.001). Fasting insulin was significantly higher and fasting glucose/insulin ratio was significantly lower in the PCOS group vs. controls (p = 0.03 and 0.001, respectively). There was significantly less subcutaneous adipose tissue in the controls than the PCOS women at the triceps (p = 0.04) and subscapular region (p = 0.04). Waist-to-hip ratio of PCOS women was significantly higher than that of control subjects (p = 0.04). CONCLUSION: Upper-half type body fat distribution is linked with PCOS, high free testosterone levels and insulin resistance. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/18850379/Body_fat_composition_and_distribution_in_women_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590802234253 DB - PRIME DP - Unbound Medicine ER -