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Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US.
Int J Geriatr Psychiatry 2009; 24(2):197-201IJ

Abstract

OBJECTIVE

Cross validation study of the MoCA for the detection of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) in a community-based cohort residing in the Southeastern United States.

METHODS

One hundred and eighteen English-speaking older adults, who underwent diagnostic evaluation as part of an on-going prospective study, were administered the MoCA and MMSE. Twenty were diagnosed with AD, 24 met criteria for amnestic MCI and 74 were considered cognitively normal. Sensitivities and specificities were calculated using the recommended cut-off scores and ROC curve analyses were performed to determine optimal sensitivity and specificity. The influence of age, education and gender on MoCA score was also examined.

RESULTS

Using a cut-off score of 24 or below, the MMSE was insensitive to cognitive impairment. Using the recommended cut-off score of 26, the MoCA detected 97% of those with cognitive impairment but specificity was fair (35%). Using a lower cut-off score of 23, the MoCA exhibited excellent sensitivity (96%) and specificity (95%).

CONCLUSION

The MoCA appears to have utility as a cognitive screen for early detection of AD and for MCI and warrants further investigation regarding its applicability in primary care settings, varying ethnic groups, and younger at-risk individuals.

Authors+Show Affiliations

Roskamp Institute, Sarasota, FL 34243, USA. cluis@rfdn.orgNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18850670

Citation

Luis, Cheryl A., et al. "Cross Validation of the Montreal Cognitive Assessment in Community Dwelling Older Adults Residing in the Southeastern US." International Journal of Geriatric Psychiatry, vol. 24, no. 2, 2009, pp. 197-201.
Luis CA, Keegan AP, Mullan M. Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US. Int J Geriatr Psychiatry. 2009;24(2):197-201.
Luis, C. A., Keegan, A. P., & Mullan, M. (2009). Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US. International Journal of Geriatric Psychiatry, 24(2), pp. 197-201. doi:10.1002/gps.2101.
Luis CA, Keegan AP, Mullan M. Cross Validation of the Montreal Cognitive Assessment in Community Dwelling Older Adults Residing in the Southeastern US. Int J Geriatr Psychiatry. 2009;24(2):197-201. PubMed PMID: 18850670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cross validation of the Montreal Cognitive Assessment in community dwelling older adults residing in the Southeastern US. AU - Luis,Cheryl A, AU - Keegan,Andrew P, AU - Mullan,Michael, PY - 2008/10/14/pubmed PY - 2009/11/3/medline PY - 2008/10/14/entrez SP - 197 EP - 201 JF - International journal of geriatric psychiatry JO - Int J Geriatr Psychiatry VL - 24 IS - 2 N2 - OBJECTIVE: Cross validation study of the MoCA for the detection of Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) in a community-based cohort residing in the Southeastern United States. METHODS: One hundred and eighteen English-speaking older adults, who underwent diagnostic evaluation as part of an on-going prospective study, were administered the MoCA and MMSE. Twenty were diagnosed with AD, 24 met criteria for amnestic MCI and 74 were considered cognitively normal. Sensitivities and specificities were calculated using the recommended cut-off scores and ROC curve analyses were performed to determine optimal sensitivity and specificity. The influence of age, education and gender on MoCA score was also examined. RESULTS: Using a cut-off score of 24 or below, the MMSE was insensitive to cognitive impairment. Using the recommended cut-off score of 26, the MoCA detected 97% of those with cognitive impairment but specificity was fair (35%). Using a lower cut-off score of 23, the MoCA exhibited excellent sensitivity (96%) and specificity (95%). CONCLUSION: The MoCA appears to have utility as a cognitive screen for early detection of AD and for MCI and warrants further investigation regarding its applicability in primary care settings, varying ethnic groups, and younger at-risk individuals. SN - 1099-1166 UR - https://www.unboundmedicine.com/medline/citation/18850670/Cross_validation_of_the_Montreal_Cognitive_Assessment_in_community_dwelling_older_adults_residing_in_the_Southeastern_US_ L2 - https://doi.org/10.1002/gps.2101 DB - PRIME DP - Unbound Medicine ER -