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A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome.
Clin Sci (Lond). 2009 May; 116(10):761-70.CS

Abstract

PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with (n=80) and without (n=27) PCOS were assessed in a cross-sectional study. End-point measures were HOMA (homoeostasis model assessment)-IR, androgens, lipids, inflammatory markers [hsCRP (high-sensitivity C-reactive protein)] and endothelial function [FMD (flow-mediated dilation), ADMA (asymmetric dimethylarginine), PAI-1 (plasminogen activator inhibitor-1) and vWF (von Willebrand factor)]. Women with PCOS had elevated HOMA-IR (4.1+/-3.4 compared with 1.9+/-1.4), free androgen index (9.3+/-5.6 compared with 4.6+/-3.8), total cholesterol (5.2+/-1.0 compared with 4.7+/-0.9 mmol/l) and triacylglycerols (triglycerides; 1.4+/-0.7 compared with 0.9+/-0.3 mmol/l) (P<0.05 for all), but similar hsCRP compared with women without PCOS. With regard to endothelial function, women with PCOS had elevated ADMA (1.0+/-0.4 compared 0.3+/-0.1 mumol/l, P<0.001) and PAI-1 (5.6+/-1.8 compared with 4.6+/-1.1 units/ml, P=0.006), a trend towards worsened FMD (11.8+/-5.0 compared with 13.5+/-4.0%, P=0.075) and no difference in vWF compared with controls. For all subjects, ADMA (P=0.002) and PAI-1 (P<0.001) were increased with higher tertiles of HOMA-IR. Women with PCOS are hyperandrogenic, dyslipidaemic and have IR, and have risk factors for CVD and diabetes including increased circulating markers of endothelial function (ADMA and PAI-1) and a trend towards worse FMD as a global marker of endothelial function. In PCOS, deterioration in endothelial function is related to IR, hyperandrogenism and other factors.

Links

Publisher Full Text

Authors+Show Affiliations

Moran LJ
The Jean Hailes Foundation for Women's Health, Monash Institute of Health Services Research, Monash University, Melbourne 3168, Australia. lisa.moran@med.monash.edu.au
Hutchison SK
No affiliation info available
Meyer C
No affiliation info available
Zoungas S
No affiliation info available
Teede HJ
No affiliation info available

MeSH

AdultBiomarkersBlood PressureCardiovascular DiseasesCross-Sectional StudiesEndothelium, VascularFemaleHumansOverweightPolycystic Ovary SyndromeRegression Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18851710

Citation

Moran, Lisa J., et al. "A Comprehensive Assessment of Endothelial Function in Overweight Women With and Without Polycystic Ovary Syndrome." Clinical Science (London, England : 1979), vol. 116, no. 10, 2009, pp. 761-70.
Moran LJ, Hutchison SK, Meyer C, et al. A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome. Clin Sci (Lond). 2009;116(10):761-70.
Moran, L. J., Hutchison, S. K., Meyer, C., Zoungas, S., & Teede, H. J. (2009). A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome. Clinical Science (London, England : 1979), 116(10), 761-70. https://doi.org/10.1042/CS20080218
Moran LJ, et al. A Comprehensive Assessment of Endothelial Function in Overweight Women With and Without Polycystic Ovary Syndrome. Clin Sci (Lond). 2009;116(10):761-70. PubMed PMID: 18851710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comprehensive assessment of endothelial function in overweight women with and without polycystic ovary syndrome. AU - Moran,Lisa J, AU - Hutchison,Samantha K, AU - Meyer,Caroline, AU - Zoungas,Sophia, AU - Teede,Helena J, PY - 2008/10/15/pubmed PY - 2009/8/1/medline PY - 2008/10/15/entrez SP - 761 EP - 70 JF - Clinical science (London, England : 1979) JO - Clin Sci (Lond) VL - 116 IS - 10 N2 - PCOS (polycystic ovary syndrome) is associated with reproductive abnormalities, IR (insulin resistance) and elevated risk factors for CVD (cardiovascular disease) and Type 2 diabetes, including endothelial dysfunction. The present study aimed to assess a range of circulating markers of endothelial function in overweight women with and without PCOS. Overweight and obese age- and BMI (body mass index)-matched women with (n=80) and without (n=27) PCOS were assessed in a cross-sectional study. End-point measures were HOMA (homoeostasis model assessment)-IR, androgens, lipids, inflammatory markers [hsCRP (high-sensitivity C-reactive protein)] and endothelial function [FMD (flow-mediated dilation), ADMA (asymmetric dimethylarginine), PAI-1 (plasminogen activator inhibitor-1) and vWF (von Willebrand factor)]. Women with PCOS had elevated HOMA-IR (4.1+/-3.4 compared with 1.9+/-1.4), free androgen index (9.3+/-5.6 compared with 4.6+/-3.8), total cholesterol (5.2+/-1.0 compared with 4.7+/-0.9 mmol/l) and triacylglycerols (triglycerides; 1.4+/-0.7 compared with 0.9+/-0.3 mmol/l) (P<0.05 for all), but similar hsCRP compared with women without PCOS. With regard to endothelial function, women with PCOS had elevated ADMA (1.0+/-0.4 compared 0.3+/-0.1 mumol/l, P<0.001) and PAI-1 (5.6+/-1.8 compared with 4.6+/-1.1 units/ml, P=0.006), a trend towards worsened FMD (11.8+/-5.0 compared with 13.5+/-4.0%, P=0.075) and no difference in vWF compared with controls. For all subjects, ADMA (P=0.002) and PAI-1 (P<0.001) were increased with higher tertiles of HOMA-IR. Women with PCOS are hyperandrogenic, dyslipidaemic and have IR, and have risk factors for CVD and diabetes including increased circulating markers of endothelial function (ADMA and PAI-1) and a trend towards worse FMD as a global marker of endothelial function. In PCOS, deterioration in endothelial function is related to IR, hyperandrogenism and other factors. SN - 1470-8736 UR - https://www.unboundmedicine.com/medline/citation/18851710/A_comprehensive_assessment_of_endothelial_function_in_overweight_women_with_and_without_polycystic_ovary_syndrome_ L2 - https://portlandpress.com/clinsci/article-lookup/doi/10.1042/CS20080218 DB - PRIME DP - Unbound Medicine ER -