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Association of genetic variation in apolipoprotein E and low density lipoprotein receptor with ischemic stroke in Northern Han Chinese.
J Neurol Sci. 2009 Jan 15; 276(1-2):118-22.JN

Abstract

BACKGROUND

Ischemic stroke is the end phenotype of a complex interaction between various genetic and environmental factors.

OBJECTIVE

We aimed to explore association of two lipid-relevant genetic variants and conventional risk factors with risk of having ischemic stroke in Northern Han Chinese.

METHODS

Genotyping was performed in 396 ischemic stroke patients and 396 controls that were all recruited from the four hospitals of Qiqihar city. Data were analyzed using chi(2) test, logistic regression and haplotype analyses.

RESULTS

Significant differences were observed for genotype and allele distributions of APOE epsilon2/epsilon3/epsilon4 polymorphism (P<0.001) with epsilon4 allele conferring a 2.19-fold risky effect (P<0.001), while no statistical differences were found for LDLR C1773T distributions. Haplotype analysis indicated the remarkable differences for haplotypes harboring APOE "epsilon2" or "epsilon4" alleles between cases and controls after the stringent Bonferroni correction. Moreover, all multiple-testing associations remained significant using false discovery rate (FDR) method. Further our multiple logistic regression analysis showed significant associations of hypertension status (OR=5.37, P<0.001) and APOE epsilon2 (OR=0.45, P<0.001) and epsilon4 (OR=1.50, P=0.003) alleles with ischemic stroke after controlling confounders, and their correlations with plasma lipid profiles were strengthened by stratification of alleles and hypertension status combined.

CONCLUSIONS

Our results not only demonstrated potential interactions of APOE epsilon2/epsilon3/epsilon4 and LDLR C1773T polymorphisms with risk of having ischemic stroke, but also added the evidence of independent role of hypertension and APOE epsilon2/epsilon3/epsilon4 polymorphism in the development of this disorder in Northern Han Chinese.

Authors+Show Affiliations

Department of Physiology, Qiqihar Medical College, Fularji District, Qiqihar, Heilongjiang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18851860

Citation

Wang, Bin, et al. "Association of Genetic Variation in Apolipoprotein E and Low Density Lipoprotein Receptor With Ischemic Stroke in Northern Han Chinese." Journal of the Neurological Sciences, vol. 276, no. 1-2, 2009, pp. 118-22.
Wang B, Zhao H, Zhou L, et al. Association of genetic variation in apolipoprotein E and low density lipoprotein receptor with ischemic stroke in Northern Han Chinese. J Neurol Sci. 2009;276(1-2):118-22.
Wang, B., Zhao, H., Zhou, L., Dai, X., Wang, D., Cao, J., & Niu, W. (2009). Association of genetic variation in apolipoprotein E and low density lipoprotein receptor with ischemic stroke in Northern Han Chinese. Journal of the Neurological Sciences, 276(1-2), 118-22. https://doi.org/10.1016/j.jns.2008.09.013
Wang B, et al. Association of Genetic Variation in Apolipoprotein E and Low Density Lipoprotein Receptor With Ischemic Stroke in Northern Han Chinese. J Neurol Sci. 2009 Jan 15;276(1-2):118-22. PubMed PMID: 18851860.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of genetic variation in apolipoprotein E and low density lipoprotein receptor with ischemic stroke in Northern Han Chinese. AU - Wang,Bin, AU - Zhao,Hongye, AU - Zhou,Li, AU - Dai,Xiaoxia, AU - Wang,Dayu, AU - Cao,Jun, AU - Niu,Wenquan, Y1 - 2008/10/11/ PY - 2008/07/04/received PY - 2008/09/02/revised PY - 2008/09/12/accepted PY - 2008/10/15/pubmed PY - 2009/3/18/medline PY - 2008/10/15/entrez SP - 118 EP - 22 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 276 IS - 1-2 N2 - BACKGROUND: Ischemic stroke is the end phenotype of a complex interaction between various genetic and environmental factors. OBJECTIVE: We aimed to explore association of two lipid-relevant genetic variants and conventional risk factors with risk of having ischemic stroke in Northern Han Chinese. METHODS: Genotyping was performed in 396 ischemic stroke patients and 396 controls that were all recruited from the four hospitals of Qiqihar city. Data were analyzed using chi(2) test, logistic regression and haplotype analyses. RESULTS: Significant differences were observed for genotype and allele distributions of APOE epsilon2/epsilon3/epsilon4 polymorphism (P<0.001) with epsilon4 allele conferring a 2.19-fold risky effect (P<0.001), while no statistical differences were found for LDLR C1773T distributions. Haplotype analysis indicated the remarkable differences for haplotypes harboring APOE "epsilon2" or "epsilon4" alleles between cases and controls after the stringent Bonferroni correction. Moreover, all multiple-testing associations remained significant using false discovery rate (FDR) method. Further our multiple logistic regression analysis showed significant associations of hypertension status (OR=5.37, P<0.001) and APOE epsilon2 (OR=0.45, P<0.001) and epsilon4 (OR=1.50, P=0.003) alleles with ischemic stroke after controlling confounders, and their correlations with plasma lipid profiles were strengthened by stratification of alleles and hypertension status combined. CONCLUSIONS: Our results not only demonstrated potential interactions of APOE epsilon2/epsilon3/epsilon4 and LDLR C1773T polymorphisms with risk of having ischemic stroke, but also added the evidence of independent role of hypertension and APOE epsilon2/epsilon3/epsilon4 polymorphism in the development of this disorder in Northern Han Chinese. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/18851860/Association_of_genetic_variation_in_apolipoprotein_E_and_low_density_lipoprotein_receptor_with_ischemic_stroke_in_Northern_Han_Chinese_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(08)00479-6 DB - PRIME DP - Unbound Medicine ER -