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Traffic-related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren.
Thorax. 2009 Jul; 64(7):573-80.T

Abstract

BACKGROUND

Urban air pollution can trigger asthma exacerbations, but the effects of long-term exposure to traffic-related air pollution on lung function or onset of airway disease and allergic sensitisation in children is less clear.

METHODS

All 2107 children aged 9-14 years from 40 schools in Rome in 2000-1 were included in a cross-sectional survey. Respiratory symptoms were assessed on 1760 children by parental questionnaires (response rate 83.5%). Allergic sensitisation was measured by skin prick tests and lung function was measured by spirometry on 1359 children (77.2%). Three indicators of traffic-related air pollution exposure were assessed: self-reported heavy traffic outside the child's home; the measured distance between the child's home and busy roads; and the residential nitrogen dioxide (NO2) levels estimated by a land use regression model (R2 = 0.69).

RESULTS

There was a strong association between estimated NO2 exposure per 10 microg/m3 and lung function, especially expiratory flows, in linear regression models adjusted for age, gender, height and weight: -0.62% (95% CI -1.05 to -0.19) for forced expiratory volume in 1 s as a percentage of forced vital capacity, -62 ml/s (95% CI -102 to -21) for forced expiratory flow between 25% and 75% of forced vital capacity and -85 ml/s (95% CI -135 to -35) for peak expiratory flow. The other two exposure indicators showed similar but weaker associations. The associations appeared stronger in girls, older children, in children of high socioeconomic status and in those exposed to parental smoking. Although lifetime asthma was not an effect modifier, there was a suggestion of a larger effect on lung function in subjects with a positive prick test. Multiple logistic regression models did not suggest a consistent association between traffic-related air pollution exposure and prevalence of respiratory symptoms or allergic sensitisation.

CONCLUSION

The results of this study suggest that residential traffic-related air pollution exposure is associated with reduced expiratory flows in schoolchildren.

Authors+Show Affiliations

Department of Epidemiology, Rome E Local Health Authority, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18852158

Citation

Rosenlund, M, et al. "Traffic-related Air Pollution in Relation to Respiratory Symptoms, Allergic Sensitisation and Lung Function in Schoolchildren." Thorax, vol. 64, no. 7, 2009, pp. 573-80.
Rosenlund M, Forastiere F, Porta D, et al. Traffic-related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren. Thorax. 2009;64(7):573-80.
Rosenlund, M., Forastiere, F., Porta, D., De Sario, M., Badaloni, C., & Perucci, C. A. (2009). Traffic-related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren. Thorax, 64(7), 573-80. https://doi.org/10.1136/thx.2007.094953
Rosenlund M, et al. Traffic-related Air Pollution in Relation to Respiratory Symptoms, Allergic Sensitisation and Lung Function in Schoolchildren. Thorax. 2009;64(7):573-80. PubMed PMID: 18852158.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Traffic-related air pollution in relation to respiratory symptoms, allergic sensitisation and lung function in schoolchildren. AU - Rosenlund,M, AU - Forastiere,F, AU - Porta,D, AU - De Sario,M, AU - Badaloni,C, AU - Perucci,C A, Y1 - 2008/10/13/ PY - 2008/10/15/pubmed PY - 2009/8/8/medline PY - 2008/10/15/entrez SP - 573 EP - 80 JF - Thorax JO - Thorax VL - 64 IS - 7 N2 - BACKGROUND: Urban air pollution can trigger asthma exacerbations, but the effects of long-term exposure to traffic-related air pollution on lung function or onset of airway disease and allergic sensitisation in children is less clear. METHODS: All 2107 children aged 9-14 years from 40 schools in Rome in 2000-1 were included in a cross-sectional survey. Respiratory symptoms were assessed on 1760 children by parental questionnaires (response rate 83.5%). Allergic sensitisation was measured by skin prick tests and lung function was measured by spirometry on 1359 children (77.2%). Three indicators of traffic-related air pollution exposure were assessed: self-reported heavy traffic outside the child's home; the measured distance between the child's home and busy roads; and the residential nitrogen dioxide (NO2) levels estimated by a land use regression model (R2 = 0.69). RESULTS: There was a strong association between estimated NO2 exposure per 10 microg/m3 and lung function, especially expiratory flows, in linear regression models adjusted for age, gender, height and weight: -0.62% (95% CI -1.05 to -0.19) for forced expiratory volume in 1 s as a percentage of forced vital capacity, -62 ml/s (95% CI -102 to -21) for forced expiratory flow between 25% and 75% of forced vital capacity and -85 ml/s (95% CI -135 to -35) for peak expiratory flow. The other two exposure indicators showed similar but weaker associations. The associations appeared stronger in girls, older children, in children of high socioeconomic status and in those exposed to parental smoking. Although lifetime asthma was not an effect modifier, there was a suggestion of a larger effect on lung function in subjects with a positive prick test. Multiple logistic regression models did not suggest a consistent association between traffic-related air pollution exposure and prevalence of respiratory symptoms or allergic sensitisation. CONCLUSION: The results of this study suggest that residential traffic-related air pollution exposure is associated with reduced expiratory flows in schoolchildren. SN - 1468-3296 UR - https://www.unboundmedicine.com/medline/citation/18852158/Traffic_related_air_pollution_in_relation_to_respiratory_symptoms_allergic_sensitisation_and_lung_function_in_schoolchildren_ L2 - https://thorax.bmj.com/lookup/pmidlookup?view=long&pmid=18852158 DB - PRIME DP - Unbound Medicine ER -