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Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease.
Arch Neurol. 2008 Oct; 65(10):1348-52.AN

Abstract

BACKGROUND

A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed.

OBJECTIVE

To compare the prevalence of vitamin D deficiency in a research database cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease (AD).

DESIGN

Survey study and blinded comparison of plasma 25-hydroxyvitamin D (25[OH]D) concentrations of stored samples in a clinical research database at Emory University School of Medicine.

SETTING

Referral center (PD and AD patients), primary care clinics, and community setting (controls).

PARTICIPANTS

Participants were recruited into the study between May 1992 and March 2007. Every fifth consecutively enrolled PD patient was selected from the clinical research database. Unrelated AD (n = 97) and control (n = 99) participants were randomly selected from the database after matching for age, sex, race, APOE genotype, and geographic location.

MAIN OUTCOME MEASURES

Prevalence of suboptimal vitamin D and mean 25(OH)D concentrations.

RESULTS

Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P = .02, chi(2)test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P = .03).

CONCLUSIONS

This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD.

Authors+Show Affiliations

Department of Neurology, Emory University School of Medicine, 1841 Clifton Road NE, Atlanta, GA 30329, USA. mevatt@emory.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18852350

Citation

Evatt, Marian L., et al. "Prevalence of Vitamin D Insufficiency in Patients With Parkinson Disease and Alzheimer Disease." Archives of Neurology, vol. 65, no. 10, 2008, pp. 1348-52.
Evatt ML, Delong MR, Khazai N, et al. Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. 2008;65(10):1348-52.
Evatt, M. L., Delong, M. R., Khazai, N., Rosen, A., Triche, S., & Tangpricha, V. (2008). Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. Archives of Neurology, 65(10), 1348-52. https://doi.org/10.1001/archneur.65.10.1348
Evatt ML, et al. Prevalence of Vitamin D Insufficiency in Patients With Parkinson Disease and Alzheimer Disease. Arch Neurol. 2008;65(10):1348-52. PubMed PMID: 18852350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of vitamin d insufficiency in patients with Parkinson disease and Alzheimer disease. AU - Evatt,Marian L, AU - Delong,Mahlon R, AU - Khazai,Natasha, AU - Rosen,Ami, AU - Triche,Shirley, AU - Tangpricha,Vin, PY - 2008/10/15/pubmed PY - 2008/11/19/medline PY - 2008/10/15/entrez SP - 1348 EP - 52 JF - Archives of neurology JO - Arch Neurol VL - 65 IS - 10 N2 - BACKGROUND: A role for vitamin D deficiency in Parkinson disease (PD) has recently been proposed. OBJECTIVE: To compare the prevalence of vitamin D deficiency in a research database cohort of patients with PD with the prevalence in age-matched healthy controls and patients with Alzheimer disease (AD). DESIGN: Survey study and blinded comparison of plasma 25-hydroxyvitamin D (25[OH]D) concentrations of stored samples in a clinical research database at Emory University School of Medicine. SETTING: Referral center (PD and AD patients), primary care clinics, and community setting (controls). PARTICIPANTS: Participants were recruited into the study between May 1992 and March 2007. Every fifth consecutively enrolled PD patient was selected from the clinical research database. Unrelated AD (n = 97) and control (n = 99) participants were randomly selected from the database after matching for age, sex, race, APOE genotype, and geographic location. MAIN OUTCOME MEASURES: Prevalence of suboptimal vitamin D and mean 25(OH)D concentrations. RESULTS: Significantly more patients with PD (55%) had insufficient vitamin D than did controls (36%) or patients with AD (41%; P = .02, chi(2)test). The mean (SD) 25(OH)D concentration in the PD cohort was significantly lower than in the AD and control cohorts (31.9 [13.6] ng/mL vs 34.8 [15.4] ng/mL and 37.0 [14.5] ng/mL, respectively; P = .03). CONCLUSIONS: This report of 25(OH)D concentrations in a predominantly white PD cohort demonstrates a significantly higher prevalence of hypovitaminosis in PD vs both healthy controls and patients with AD. These data support a possible role of vitamin D insufficiency in PD. Further studies are needed to determine the factors contributing to these differences and elucidate the potential role of vitamin D in pathogenesis and clinical course of PD. SN - 1538-3687 UR - https://www.unboundmedicine.com/medline/citation/18852350/Prevalence_of_vitamin_d_insufficiency_in_patients_with_Parkinson_disease_and_Alzheimer_disease_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/10.1001/archneur.65.10.1348 DB - PRIME DP - Unbound Medicine ER -