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Combined esophageal multichannel intraluminal impedance and pH monitoring after repair of esophageal atresia.
J Pediatr Gastroenterol Nutr 2008; 47(4):443-9JP

Abstract

OBJECTIVE

Gastroesophageal reflux disease and impaired esophageal motility is a frequent problem after repair of esophageal atresia (EA). Combined multichannel intraluminal impedance (MII) and pH measurement identifies acidic and weakly acidic esophageal bolus movements. Our aim was to evaluate gastroesophageal reflux and its association with gastrointestinal or extraintestinal symptoms using combined MII-pH measurement.

PATIENTS AND METHODS

In all, 24 patients (4 months-23 years; 17 male, 7 female) with repaired EA were included in this study. A single catheter with 6 impedance channels and 1 pH channel was used to perform the 24-hour MII-pH study. Symptoms were recorded during the study as events and with a standardized questionnaire. In a subgroup of patients, an impedance swallowing test evaluating liquid and viscous bolus movements was performed.

RESULTS

We detected a total of 911 episodes of retrograde bolus movement, 379 acidic and 532 weakly acidic bolus movements. In all, 201 symptom events were recorded. Of these events, 42% were associated with retrograde bolus movements. More symptom events were associated with weakly acidic reflux (26%) than with acid reflux episodes (16%). There was a poor correlation between symptoms and MII-pH study findings. In comparison with patients without esophageal surgery, EA patients showed significantly fewer complete swallows of liquid (42% vs 98%) and viscous material (18% vs 87%).

CONCLUSIONS

In patients with corrected EA, half of the reflux events could be detected only by MII. We also demonstrated that weakly acidic reflux can be responsible for the patients' symptoms. However, patients may have few or no symptoms despite poor esophageal function and extensive gastroesophageal reflux disease.

Authors+Show Affiliations

Kinder- und Jugendklinik, Universitätsklinikum Erlangen, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18852636

Citation

Fröhlich, Thorsten, et al. "Combined Esophageal Multichannel Intraluminal Impedance and pH Monitoring After Repair of Esophageal Atresia." Journal of Pediatric Gastroenterology and Nutrition, vol. 47, no. 4, 2008, pp. 443-9.
Fröhlich T, Otto S, Weber P, et al. Combined esophageal multichannel intraluminal impedance and pH monitoring after repair of esophageal atresia. J Pediatr Gastroenterol Nutr. 2008;47(4):443-9.
Fröhlich, T., Otto, S., Weber, P., Pilic, D., Schmidt-Choudhury, A., Wenzl, T. G., & Köhler, H. (2008). Combined esophageal multichannel intraluminal impedance and pH monitoring after repair of esophageal atresia. Journal of Pediatric Gastroenterology and Nutrition, 47(4), pp. 443-9. doi:10.1097/MPG.0b013e3181638ca2.
Fröhlich T, et al. Combined Esophageal Multichannel Intraluminal Impedance and pH Monitoring After Repair of Esophageal Atresia. J Pediatr Gastroenterol Nutr. 2008;47(4):443-9. PubMed PMID: 18852636.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined esophageal multichannel intraluminal impedance and pH monitoring after repair of esophageal atresia. AU - Fröhlich,Thorsten, AU - Otto,Stephanie, AU - Weber,Peter, AU - Pilic,Denisa, AU - Schmidt-Choudhury,Anjona, AU - Wenzl,Tobias G, AU - Köhler,Henrik, PY - 2008/10/15/pubmed PY - 2009/2/10/medline PY - 2008/10/15/entrez SP - 443 EP - 9 JF - Journal of pediatric gastroenterology and nutrition JO - J. Pediatr. Gastroenterol. Nutr. VL - 47 IS - 4 N2 - OBJECTIVE: Gastroesophageal reflux disease and impaired esophageal motility is a frequent problem after repair of esophageal atresia (EA). Combined multichannel intraluminal impedance (MII) and pH measurement identifies acidic and weakly acidic esophageal bolus movements. Our aim was to evaluate gastroesophageal reflux and its association with gastrointestinal or extraintestinal symptoms using combined MII-pH measurement. PATIENTS AND METHODS: In all, 24 patients (4 months-23 years; 17 male, 7 female) with repaired EA were included in this study. A single catheter with 6 impedance channels and 1 pH channel was used to perform the 24-hour MII-pH study. Symptoms were recorded during the study as events and with a standardized questionnaire. In a subgroup of patients, an impedance swallowing test evaluating liquid and viscous bolus movements was performed. RESULTS: We detected a total of 911 episodes of retrograde bolus movement, 379 acidic and 532 weakly acidic bolus movements. In all, 201 symptom events were recorded. Of these events, 42% were associated with retrograde bolus movements. More symptom events were associated with weakly acidic reflux (26%) than with acid reflux episodes (16%). There was a poor correlation between symptoms and MII-pH study findings. In comparison with patients without esophageal surgery, EA patients showed significantly fewer complete swallows of liquid (42% vs 98%) and viscous material (18% vs 87%). CONCLUSIONS: In patients with corrected EA, half of the reflux events could be detected only by MII. We also demonstrated that weakly acidic reflux can be responsible for the patients' symptoms. However, patients may have few or no symptoms despite poor esophageal function and extensive gastroesophageal reflux disease. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/18852636/Combined_esophageal_multichannel_intraluminal_impedance_and_pH_monitoring_after_repair_of_esophageal_atresia_ L2 - http://dx.doi.org/10.1097/MPG.0b013e3181638ca2 DB - PRIME DP - Unbound Medicine ER -