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8-Hydroxy-2'-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection.
J Gastroenterol Hepatol 2008; 23(9):1431-6JG

Abstract

BACKGROUND AND AIM

Increased production of reactive oxygen species, which cause oxidative DNA damage, is considered to be related to hepatocarcinogenesis. 8-Hydroxy-2'-deoxy-guanosine (8-OHdG) is a useful marker of DNA damage induced by oxidative stress. The aim of this study was to determine whether expression of 8-OHdG is a risk factor for the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection.

METHODS

The expression of 8-OHdG in liver biopsy specimens was assessed immunohistochemically. In total, 104 patients with chronic HCV infection who were diagnosed on liver biopsy between January 1987 and December 2002 were studied retrospectively. Univariate and multivariate analyses using age, gender, habitual drinking, tobacco exposure, diabetes mellitus, serum alanine aminotransferase level, HCV genotype, hepatic fibrosis, inflammation, steatosis, and 8-OHdG expression in liver biopsy specimens were conducted to identify factors related to the development of HCC.

RESULTS

On multivariate analysis, 8-OHdG and fibrosis were independent and significant risk factors for HCC development (relative risk, 2.48; P = 0.023; relative risk, 5.35; P = 0.001, respectively). Furthermore, the cumulative incidence rate of HCC in 39 patients with high 8-OHdG expression levels was significantly greater than that in 65 patients with low 8-OHdG expression levels (P = 0.043). In addition, liver 8-OHdG expression was correlated with hepatic inflammation.

CONCLUSIONS

8-OHdG is a risk factor for the development of HCC in patients with chronic HCV infection. Patients with chronic HCV who express 8-OHdG should be monitored carefully for the development of HCC.

Authors+Show Affiliations

Department of Gastroentelology and Hematology, Hokkaido University Hospital, Kitaku, Sapporo, Japan. mchuuma@med.hokudai.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18854000

Citation

Chuma, Makoto, et al. "8-Hydroxy-2'-deoxy-guanosine Is a Risk Factor for Development of Hepatocellular Carcinoma in Patients With Chronic Hepatitis C Virus Infection." Journal of Gastroenterology and Hepatology, vol. 23, no. 9, 2008, pp. 1431-6.
Chuma M, Hige S, Nakanishi M, et al. 8-Hydroxy-2'-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. J Gastroenterol Hepatol. 2008;23(9):1431-6.
Chuma, M., Hige, S., Nakanishi, M., Ogawa, K., Natsuizaka, M., Yamamoto, Y., & Asaka, M. (2008). 8-Hydroxy-2'-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. Journal of Gastroenterology and Hepatology, 23(9), pp. 1431-6. doi:10.1111/j.1440-1746.2008.05502.x.
Chuma M, et al. 8-Hydroxy-2'-deoxy-guanosine Is a Risk Factor for Development of Hepatocellular Carcinoma in Patients With Chronic Hepatitis C Virus Infection. J Gastroenterol Hepatol. 2008;23(9):1431-6. PubMed PMID: 18854000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 8-Hydroxy-2'-deoxy-guanosine is a risk factor for development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection. AU - Chuma,Makoto, AU - Hige,Shuhei, AU - Nakanishi,Mitsuru, AU - Ogawa,Koji, AU - Natsuizaka,Mitsuteru, AU - Yamamoto,Yoichi, AU - Asaka,Masahiro, PY - 2008/10/16/pubmed PY - 2009/1/24/medline PY - 2008/10/16/entrez SP - 1431 EP - 6 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 23 IS - 9 N2 - BACKGROUND AND AIM: Increased production of reactive oxygen species, which cause oxidative DNA damage, is considered to be related to hepatocarcinogenesis. 8-Hydroxy-2'-deoxy-guanosine (8-OHdG) is a useful marker of DNA damage induced by oxidative stress. The aim of this study was to determine whether expression of 8-OHdG is a risk factor for the development of hepatocellular carcinoma (HCC) in patients with hepatitis C virus (HCV) infection. METHODS: The expression of 8-OHdG in liver biopsy specimens was assessed immunohistochemically. In total, 104 patients with chronic HCV infection who were diagnosed on liver biopsy between January 1987 and December 2002 were studied retrospectively. Univariate and multivariate analyses using age, gender, habitual drinking, tobacco exposure, diabetes mellitus, serum alanine aminotransferase level, HCV genotype, hepatic fibrosis, inflammation, steatosis, and 8-OHdG expression in liver biopsy specimens were conducted to identify factors related to the development of HCC. RESULTS: On multivariate analysis, 8-OHdG and fibrosis were independent and significant risk factors for HCC development (relative risk, 2.48; P = 0.023; relative risk, 5.35; P = 0.001, respectively). Furthermore, the cumulative incidence rate of HCC in 39 patients with high 8-OHdG expression levels was significantly greater than that in 65 patients with low 8-OHdG expression levels (P = 0.043). In addition, liver 8-OHdG expression was correlated with hepatic inflammation. CONCLUSIONS: 8-OHdG is a risk factor for the development of HCC in patients with chronic HCV infection. Patients with chronic HCV who express 8-OHdG should be monitored carefully for the development of HCC. SN - 1440-1746 UR - https://www.unboundmedicine.com/medline/citation/18854000/8_Hydroxy_2'_deoxy_guanosine_is_a_risk_factor_for_development_of_hepatocellular_carcinoma_in_patients_with_chronic_hepatitis_C_virus_infection_ L2 - https://doi.org/10.1111/j.1440-1746.2008.05502.x DB - PRIME DP - Unbound Medicine ER -