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Deep brain stimulation parameters associated with neuropsychological changes in subthalamic nucleus stimulation for refractory Parkinson's disease.
Stereotact Funct Neurosurg. 2008; 86(6):337-44.SF

Abstract

BACKGROUND/AIMS

Parkinson's disease (PD) is an idiopathic progressive neurological disorder. Improvement in motor function of PD patients has been established with subthalamic nucleus (STN) deep brain stimulation (DBS). While variations in DBS settings (i.e. amplitude, frequency and pulse width) on motor function have been explored, little data has evaluated the relationship of DBS settings on cognitive function. This study evaluated the extent to which DBS settings were associated with cognitive function.

METHODS

The study was a prospective clinical trial of STN DBS for the treatment of refractory PD. Twenty patients were evaluated once preoperatively and an average of 5 months following bilateral STN DBS. Measures included a test of motor disability, a neuropsychological test battery and subjective mood measures of anxiety and depression.

RESULTS

Motor function significantly improved following bilateral STN DBS. Compared to preoperative performance, verbal fluency declined while visuoconstructional skills improved. Amplitude and pulse width were significantly correlated with measures of cognitive function. Multiple regression found DBS stimulator settings, along with anxiety, to be significant predictors of cognitive measures.

CONCLUSION

Increased amplitude and pulse width and decreased anxiety were associated with improved cognitive test scores. Although preliminary, these data have potential theoretical and clinical applications.

Authors+Show Affiliations

University Hospitals Case Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA. mschoenb@health.usf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

18854660

Citation

Schoenberg, Mike R., et al. "Deep Brain Stimulation Parameters Associated With Neuropsychological Changes in Subthalamic Nucleus Stimulation for Refractory Parkinson's Disease." Stereotactic and Functional Neurosurgery, vol. 86, no. 6, 2008, pp. 337-44.
Schoenberg MR, Mash KM, Bharucha KJ, et al. Deep brain stimulation parameters associated with neuropsychological changes in subthalamic nucleus stimulation for refractory Parkinson's disease. Stereotact Funct Neurosurg. 2008;86(6):337-44.
Schoenberg, M. R., Mash, K. M., Bharucha, K. J., Francel, P. C., & Scott, J. G. (2008). Deep brain stimulation parameters associated with neuropsychological changes in subthalamic nucleus stimulation for refractory Parkinson's disease. Stereotactic and Functional Neurosurgery, 86(6), 337-44. https://doi.org/10.1159/000163554
Schoenberg MR, et al. Deep Brain Stimulation Parameters Associated With Neuropsychological Changes in Subthalamic Nucleus Stimulation for Refractory Parkinson's Disease. Stereotact Funct Neurosurg. 2008;86(6):337-44. PubMed PMID: 18854660.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deep brain stimulation parameters associated with neuropsychological changes in subthalamic nucleus stimulation for refractory Parkinson's disease. AU - Schoenberg,Mike R, AU - Mash,Kathleen M, AU - Bharucha,Kersi J, AU - Francel,Paul C, AU - Scott,James G, Y1 - 2008/10/16/ PY - 2008/10/16/pubmed PY - 2009/6/10/medline PY - 2008/10/16/entrez SP - 337 EP - 44 JF - Stereotactic and functional neurosurgery JO - Stereotact Funct Neurosurg VL - 86 IS - 6 N2 - BACKGROUND/AIMS: Parkinson's disease (PD) is an idiopathic progressive neurological disorder. Improvement in motor function of PD patients has been established with subthalamic nucleus (STN) deep brain stimulation (DBS). While variations in DBS settings (i.e. amplitude, frequency and pulse width) on motor function have been explored, little data has evaluated the relationship of DBS settings on cognitive function. This study evaluated the extent to which DBS settings were associated with cognitive function. METHODS: The study was a prospective clinical trial of STN DBS for the treatment of refractory PD. Twenty patients were evaluated once preoperatively and an average of 5 months following bilateral STN DBS. Measures included a test of motor disability, a neuropsychological test battery and subjective mood measures of anxiety and depression. RESULTS: Motor function significantly improved following bilateral STN DBS. Compared to preoperative performance, verbal fluency declined while visuoconstructional skills improved. Amplitude and pulse width were significantly correlated with measures of cognitive function. Multiple regression found DBS stimulator settings, along with anxiety, to be significant predictors of cognitive measures. CONCLUSION: Increased amplitude and pulse width and decreased anxiety were associated with improved cognitive test scores. Although preliminary, these data have potential theoretical and clinical applications. SN - 1423-0372 UR - https://www.unboundmedicine.com/medline/citation/18854660/Deep_brain_stimulation_parameters_associated_with_neuropsychological_changes_in_subthalamic_nucleus_stimulation_for_refractory_Parkinson's_disease_ L2 - https://www.karger.com?DOI=10.1159/000163554 DB - PRIME DP - Unbound Medicine ER -