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Uric acid: bystander or culprit in hypertension and progressive renal disease?
J Hypertens. 2008 Nov; 26(11):2085-92.JH

Abstract

In humans, uric acid is the main urinary metabolite of purines. Serum levels are higher compared with other mammalians. Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system. Serum uric acid is also considered a marker of tubular reabsorption and 'effective' circulating blood volume. Moreover, hyperuricemia seems to be a cofactor in Na+ -sensitive hypertension, a marker and possibly itself responsible for microvascular damage through stimulation of the renin-angiotensin system, inhibition of endothelial nitric oxide, and proliferative effects on vascular smooth muscle. As fructose-rich diets increase uric acid levels, hyperuricemia may also play a role in the metabolic syndrome, triggering insulin resistance and hypertension.A number of studies on rats rendered hyperuricemic by administration of uricase inhibitors have recently confirmed induction of arterial hypertension and microvascular injury, particularly in the remnant kidney or in cyclosporine-induced renal fibrosis.

Authors+Show Affiliations

Department of Clinical Sciences, Italy, Sant'Andrea University Hospital, University La Sapienza of Rome, Rome, Italy. Paolo.Mene@uniroma1.itNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18854744

Citation

Menè, Paolo, and Giorgio Punzo. "Uric Acid: Bystander or Culprit in Hypertension and Progressive Renal Disease?" Journal of Hypertension, vol. 26, no. 11, 2008, pp. 2085-92.
Menè P, Punzo G. Uric acid: bystander or culprit in hypertension and progressive renal disease? J Hypertens. 2008;26(11):2085-92.
Menè, P., & Punzo, G. (2008). Uric acid: bystander or culprit in hypertension and progressive renal disease? Journal of Hypertension, 26(11), 2085-92. https://doi.org/10.1097/HJH.0b013e32830e4945
Menè P, Punzo G. Uric Acid: Bystander or Culprit in Hypertension and Progressive Renal Disease. J Hypertens. 2008;26(11):2085-92. PubMed PMID: 18854744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Uric acid: bystander or culprit in hypertension and progressive renal disease? AU - Menè,Paolo, AU - Punzo,Giorgio, PY - 2008/10/16/pubmed PY - 2008/11/18/medline PY - 2008/10/16/entrez SP - 2085 EP - 92 JF - Journal of hypertension JO - J Hypertens VL - 26 IS - 11 N2 - In humans, uric acid is the main urinary metabolite of purines. Serum levels are higher compared with other mammalians. Uric acid is an antioxidant and perhaps helps to control blood pressure during a low Na+ diet through stimulation of the renin-angiotensin system. Serum uric acid is also considered a marker of tubular reabsorption and 'effective' circulating blood volume. Moreover, hyperuricemia seems to be a cofactor in Na+ -sensitive hypertension, a marker and possibly itself responsible for microvascular damage through stimulation of the renin-angiotensin system, inhibition of endothelial nitric oxide, and proliferative effects on vascular smooth muscle. As fructose-rich diets increase uric acid levels, hyperuricemia may also play a role in the metabolic syndrome, triggering insulin resistance and hypertension.A number of studies on rats rendered hyperuricemic by administration of uricase inhibitors have recently confirmed induction of arterial hypertension and microvascular injury, particularly in the remnant kidney or in cyclosporine-induced renal fibrosis. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/18854744/Uric_acid:_bystander_or_culprit_in_hypertension_and_progressive_renal_disease L2 - https://doi.org/10.1097/HJH.0b013e32830e4945 DB - PRIME DP - Unbound Medicine ER -