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Clinical profile and management of hypertensive patients with chronic ischemic heart disease and renal dysfunction attended by cardiologists in daily clinical practice.
J Hypertens. 2008 Nov; 26(11):2230-5.JH

Abstract

OBJECTIVE

The present study was designed to assess the influence of renal function on the clinical profile and management of the hypertensive outpatients with chronic ischemic heart disease.

METHODS

A total of 112 investigators, all cardiologists, were asked to consecutively enrol outpatients of at least 18 years of age, both sexes, with an established diagnosis of hypertension and chronic ischemic heart disease. Renal function was assessed by serum creatinine levels and estimated glomerular filtration rate using the Modification of Diet in Renal Disease formula. Renal impairment was considered a serum creatinine of at least 1.2/1.3 mg/dl (women/men) or an estimated glomerular filtration rate less than 60 ml/min/1.73 m2. Blood pressure was considered controlled when it was less than 140/90 mmHg and less than 130/80 mmHg in diabetic patients or patients with chronic kidney disease.

RESULTS

A total of 2024 patients (66.8+/-10.1 years; 31.7% women) were included. A total of 666 (32.9%) and 498 (24.6%) patients exhibited renal function impairment assessed by estimated glomerular filtration rate and serum creatinine, respectively. The subgroup of patients with renal dysfunction was older, with a higher proportion of women with atrial fibrillation, diabetes, organ damage, associated clinical conditions and a worse blood pressure control. No differences were found in clinical profile when the two subgroups of patients with impaired renal function [serum creatinine >or=1.2/>or=1.3 mg/dl (women/men) vs. estimated glomerular filtration rate <60 ml/min per 1.73 m2] were compared.

CONCLUSION

Renal function impairment is frequent in the hypertensive population with coronary artery disease. Patients with renal dysfunction represent a subgroup of very high-risk population with more risk factors and comorbidities and worse blood pressure control. The clinical profiles of hypertensive patients with renal function impairment are similar whether renal dysfunction is detected by high serum creatinine or by low estimated glomerular filtration rate.

Authors+Show Affiliations

Department of Cardiology, Hospital Ramon y Cajal, Madrid, Spain. vbarriosa@meditex.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18854765

Citation

Barrios, Vivencio, et al. "Clinical Profile and Management of Hypertensive Patients With Chronic Ischemic Heart Disease and Renal Dysfunction Attended By Cardiologists in Daily Clinical Practice." Journal of Hypertension, vol. 26, no. 11, 2008, pp. 2230-5.
Barrios V, Escobar C, Murga N, et al. Clinical profile and management of hypertensive patients with chronic ischemic heart disease and renal dysfunction attended by cardiologists in daily clinical practice. J Hypertens. 2008;26(11):2230-5.
Barrios, V., Escobar, C., Murga, N., de Pablo, C., Bertomeu, V., Calderón, A., & Echarri, R. (2008). Clinical profile and management of hypertensive patients with chronic ischemic heart disease and renal dysfunction attended by cardiologists in daily clinical practice. Journal of Hypertension, 26(11), 2230-5. https://doi.org/10.1097/HJH.0b013e328311cdee
Barrios V, et al. Clinical Profile and Management of Hypertensive Patients With Chronic Ischemic Heart Disease and Renal Dysfunction Attended By Cardiologists in Daily Clinical Practice. J Hypertens. 2008;26(11):2230-5. PubMed PMID: 18854765.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical profile and management of hypertensive patients with chronic ischemic heart disease and renal dysfunction attended by cardiologists in daily clinical practice. AU - Barrios,Vivencio, AU - Escobar,Carlos, AU - Murga,Nekane, AU - de Pablo,Carmen, AU - Bertomeu,Vicente, AU - Calderón,Alberto, AU - Echarri,Rocio, PY - 2008/10/16/pubmed PY - 2008/11/18/medline PY - 2008/10/16/entrez SP - 2230 EP - 5 JF - Journal of hypertension JO - J Hypertens VL - 26 IS - 11 N2 - OBJECTIVE: The present study was designed to assess the influence of renal function on the clinical profile and management of the hypertensive outpatients with chronic ischemic heart disease. METHODS: A total of 112 investigators, all cardiologists, were asked to consecutively enrol outpatients of at least 18 years of age, both sexes, with an established diagnosis of hypertension and chronic ischemic heart disease. Renal function was assessed by serum creatinine levels and estimated glomerular filtration rate using the Modification of Diet in Renal Disease formula. Renal impairment was considered a serum creatinine of at least 1.2/1.3 mg/dl (women/men) or an estimated glomerular filtration rate less than 60 ml/min/1.73 m2. Blood pressure was considered controlled when it was less than 140/90 mmHg and less than 130/80 mmHg in diabetic patients or patients with chronic kidney disease. RESULTS: A total of 2024 patients (66.8+/-10.1 years; 31.7% women) were included. A total of 666 (32.9%) and 498 (24.6%) patients exhibited renal function impairment assessed by estimated glomerular filtration rate and serum creatinine, respectively. The subgroup of patients with renal dysfunction was older, with a higher proportion of women with atrial fibrillation, diabetes, organ damage, associated clinical conditions and a worse blood pressure control. No differences were found in clinical profile when the two subgroups of patients with impaired renal function [serum creatinine >or=1.2/>or=1.3 mg/dl (women/men) vs. estimated glomerular filtration rate <60 ml/min per 1.73 m2] were compared. CONCLUSION: Renal function impairment is frequent in the hypertensive population with coronary artery disease. Patients with renal dysfunction represent a subgroup of very high-risk population with more risk factors and comorbidities and worse blood pressure control. The clinical profiles of hypertensive patients with renal function impairment are similar whether renal dysfunction is detected by high serum creatinine or by low estimated glomerular filtration rate. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/18854765/Clinical_profile_and_management_of_hypertensive_patients_with_chronic_ischemic_heart_disease_and_renal_dysfunction_attended_by_cardiologists_in_daily_clinical_practice_ L2 - https://doi.org/10.1097/HJH.0b013e328311cdee DB - PRIME DP - Unbound Medicine ER -