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The development of disseminated intravascular coagulation in hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP) at very early gestational age.
Minerva Ginecol. 2008 Oct; 60(5):445-50.MG

Abstract

Hemolysis, elevated liver enzymes, and low platelet count syndrome(HELLP) is a severe pregnancy complication since it is life-threatening for both mother and fetus. When HELLP syndrome associates with disseminated intravascular coagulation (DIC) or with other complications it is necessary to terminate the pregnancy; however, due to fetal prematurity, it may be advisable to wait for the effectiveness of the corticosteroid prophylaxis of neonatal respiratory distress syndrome when such complications are not present. This article reports an initially mild HELLP syndrome case, with onset at week 26 and two days of pregnancy, where it was necessary to wait for the effectiveness of respiratory distress prophylaxis and, consequently, to carry out a close monitoring of the onset and worsening of DIC. Tests for blood cell distribution width, D-dimer, plasmatic electrolytes and urinary sediment, which undergo precocious and rapid variations in DIC, are quickly processed, and useful for the conservative management of HELLP.

Authors+Show Affiliations

Indraccolo U
Department of Surgical Sciences, Institute of Obstetrics and Gynecology, University of Foggia, Foggia, Italy. ugo.indraccolo@libero.it
Gentile G
No affiliation info available
Manfreda VM
No affiliation info available
Pomili G
No affiliation info available

MeSH

AdultDisseminated Intravascular CoagulationFemaleHELLP SyndromeHumansPregnancyPregnancy Trimester, Second

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18854811

Citation

Indraccolo, U, et al. "The Development of Disseminated Intravascular Coagulation in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome (HELLP) at Very Early Gestational Age." Minerva Ginecologica, vol. 60, no. 5, 2008, pp. 445-50.
Indraccolo U, Gentile G, Manfreda VM, et al. The development of disseminated intravascular coagulation in hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP) at very early gestational age. Minerva Ginecol. 2008;60(5):445-50.
Indraccolo, U., Gentile, G., Manfreda, V. M., & Pomili, G. (2008). The development of disseminated intravascular coagulation in hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP) at very early gestational age. Minerva Ginecologica, 60(5), 445-50.
Indraccolo U, et al. The Development of Disseminated Intravascular Coagulation in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count Syndrome (HELLP) at Very Early Gestational Age. Minerva Ginecol. 2008;60(5):445-50. PubMed PMID: 18854811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The development of disseminated intravascular coagulation in hemolysis, elevated liver enzymes, and low platelet count syndrome (HELLP) at very early gestational age. AU - Indraccolo,U, AU - Gentile,G, AU - Manfreda,V M, AU - Pomili,G, PY - 2008/10/16/pubmed PY - 2009/3/6/medline PY - 2008/10/16/entrez SP - 445 EP - 50 JF - Minerva ginecologica JO - Minerva Ginecol VL - 60 IS - 5 N2 - Hemolysis, elevated liver enzymes, and low platelet count syndrome(HELLP) is a severe pregnancy complication since it is life-threatening for both mother and fetus. When HELLP syndrome associates with disseminated intravascular coagulation (DIC) or with other complications it is necessary to terminate the pregnancy; however, due to fetal prematurity, it may be advisable to wait for the effectiveness of the corticosteroid prophylaxis of neonatal respiratory distress syndrome when such complications are not present. This article reports an initially mild HELLP syndrome case, with onset at week 26 and two days of pregnancy, where it was necessary to wait for the effectiveness of respiratory distress prophylaxis and, consequently, to carry out a close monitoring of the onset and worsening of DIC. Tests for blood cell distribution width, D-dimer, plasmatic electrolytes and urinary sediment, which undergo precocious and rapid variations in DIC, are quickly processed, and useful for the conservative management of HELLP. SN - 0026-4784 UR - https://www.unboundmedicine.com/medline/citation/18854811/The_development_of_disseminated_intravascular_coagulation_in_hemolysis_elevated_liver_enzymes_and_low_platelet_count_syndrome__HELLP__at_very_early_gestational_age_ L2 - http://www.diseaseinfosearch.org/result/3266 DB - PRIME DP - Unbound Medicine ER -