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Cannabis smoke condensate II: influence of tobacco on tetrahydrocannabinol levels.
Inhal Toxicol. 2009 Feb; 21(2):87-90.IT

Abstract

Medicinal cannabis has attracted a lot of attention in recent times. Various forms of administration are used, of which smoking is very common but the least desirable. Smoking cannabis generates a large amount of unwanted side products, of which carcinogenic compounds are the most dangerous. A common practice among recreational drug users, and to a lesser degree patients who uses cannabis as medicine, is to mix the cannabis material with commercially available tobacco in order to increase the burning efficiency of the cigarette and to reduce the overall costs of the cigarette. In this study cannabis material has been mixed with tobacco in order to determine whether tobacco has an influence on the amount of and ratio between tetrahydrocannabinol (THC), cannabigerol (CBG), and cannabinol (CBN) administered while smoking. A small-scale smoking machine has been used and cannabis mixed with various ratios of tobacco was smoked. The trapped smoke was quantitatively analyzed by high-performance liquid chromatography (HPLC) and the amount of THC, CBG, and CBN was determined for each cigarette. We have found that tobacco increases the amount of THC inhaled per gram of cannabis from 32.70 +/- 2.29 mg/g for a 100% cannabis cigarette to 58.90 +/- 2.30 mg/g for a 25% cannabis cigarette. This indicates that tobacco increases the vaporization efficiency of THC by as much as 45% under the conditions tested.

Authors+Show Affiliations

Division of Pharmacognosy, Section of Metabolomics, Institute of Biology, Leiden University, Leiden, The Netherlands. f.vanderkooy@chem.leidenuniv.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18855154

Citation

Van der Kooy, F, et al. "Cannabis Smoke Condensate II: Influence of Tobacco On Tetrahydrocannabinol Levels." Inhalation Toxicology, vol. 21, no. 2, 2009, pp. 87-90.
Van der Kooy F, Pomahacova B, Verpoorte R. Cannabis smoke condensate II: influence of tobacco on tetrahydrocannabinol levels. Inhal Toxicol. 2009;21(2):87-90.
Van der Kooy, F., Pomahacova, B., & Verpoorte, R. (2009). Cannabis smoke condensate II: influence of tobacco on tetrahydrocannabinol levels. Inhalation Toxicology, 21(2), 87-90. https://doi.org/10.1080/08958370802187296
Van der Kooy F, Pomahacova B, Verpoorte R. Cannabis Smoke Condensate II: Influence of Tobacco On Tetrahydrocannabinol Levels. Inhal Toxicol. 2009;21(2):87-90. PubMed PMID: 18855154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabis smoke condensate II: influence of tobacco on tetrahydrocannabinol levels. AU - Van der Kooy,F, AU - Pomahacova,B, AU - Verpoorte,R, PY - 2008/10/16/pubmed PY - 2009/3/24/medline PY - 2008/10/16/entrez SP - 87 EP - 90 JF - Inhalation toxicology JO - Inhal Toxicol VL - 21 IS - 2 N2 - Medicinal cannabis has attracted a lot of attention in recent times. Various forms of administration are used, of which smoking is very common but the least desirable. Smoking cannabis generates a large amount of unwanted side products, of which carcinogenic compounds are the most dangerous. A common practice among recreational drug users, and to a lesser degree patients who uses cannabis as medicine, is to mix the cannabis material with commercially available tobacco in order to increase the burning efficiency of the cigarette and to reduce the overall costs of the cigarette. In this study cannabis material has been mixed with tobacco in order to determine whether tobacco has an influence on the amount of and ratio between tetrahydrocannabinol (THC), cannabigerol (CBG), and cannabinol (CBN) administered while smoking. A small-scale smoking machine has been used and cannabis mixed with various ratios of tobacco was smoked. The trapped smoke was quantitatively analyzed by high-performance liquid chromatography (HPLC) and the amount of THC, CBG, and CBN was determined for each cigarette. We have found that tobacco increases the amount of THC inhaled per gram of cannabis from 32.70 +/- 2.29 mg/g for a 100% cannabis cigarette to 58.90 +/- 2.30 mg/g for a 25% cannabis cigarette. This indicates that tobacco increases the vaporization efficiency of THC by as much as 45% under the conditions tested. SN - 1091-7691 UR - https://www.unboundmedicine.com/medline/citation/18855154/Cannabis_smoke_condensate_II:_influence_of_tobacco_on_tetrahydrocannabinol_levels_ L2 - https://www.tandfonline.com/doi/full/10.1080/08958370802187296 DB - PRIME DP - Unbound Medicine ER -