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Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred?
Acta Radiol. 2008 Dec; 49(10):1104-11.AR

Abstract

BACKGROUND

When a palpable breast mass is detected, a biopsy is usually performed even if the mass reveals probably benign morphologic features on imaging, as there is relatively little data reporting the outcome of such breast masses.

PURPOSE

To determine the negative predictive value for sonographic evaluation of palpable breast masses with probably benign morphology, and to assess whether follow-up may be an acceptable alternative to immediate biopsy.

MATERIAL AND METHODS

Of the 1399 sonograms of palpable masses from January 2004 to September 2005, there were 397 patients with masses of probably benign morphology. This study included 274 of these patients (age range 12-64 years, mean age 34 years) with 312 palpable masses that were pathologically confirmed by fine-needle aspiration (n=7), ultrasound (US)-guided core needle biopsy (n=180), or surgical biopsy (n=125). The false-negative rate, negative predictive value (NPV), and 95% confidence interval (CI) were calculated using the SPSS statistical software package for Windows, version 12.0. A P value <0.05 was considered statistically significant.

RESULTS

Of the 312 masses, there were 310 benign lesions and two malignancies, resulting in a false-negative rate of 0.6% (NPV 99.4%, P value=0.0432, 95% CI 0.0-1.5%).

CONCLUSION

The negative predictive value of sonography for palpable breast masses with probably benign morphology is high (99.4%). Therefore, short-term imaging follow-up can be an acceptable alternative to immediate biopsy, similar to the management of nonpalpable probably benign lesions (BI-RADS category 3).

Authors+Show Affiliations

Department of Radiology, Inje University College of Medicine, Busan, Korea. pymrad@yahoo.co.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18855166

Citation

Park, Y-M, et al. "Palpable Breast Masses With Probably Benign Morphology at Sonography: Can Biopsy Be Deferred?" Acta Radiologica (Stockholm, Sweden : 1987), vol. 49, no. 10, 2008, pp. 1104-11.
Park YM, Kim EK, Lee JH, et al. Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred? Acta Radiol. 2008;49(10):1104-11.
Park, Y. M., Kim, E. K., Lee, J. H., Ryu, J. H., Han, S. S., Choi, S. J., Lee, S. J., & Yoon, H. K. (2008). Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred? Acta Radiologica (Stockholm, Sweden : 1987), 49(10), 1104-11. https://doi.org/10.1080/02841850802438504
Park YM, et al. Palpable Breast Masses With Probably Benign Morphology at Sonography: Can Biopsy Be Deferred. Acta Radiol. 2008;49(10):1104-11. PubMed PMID: 18855166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palpable breast masses with probably benign morphology at sonography: can biopsy be deferred? AU - Park,Y-M, AU - Kim,E-K, AU - Lee,J-H, AU - Ryu,J-H, AU - Han,S-S, AU - Choi,S-J, AU - Lee,S-J, AU - Yoon,H-K, PY - 2008/10/16/pubmed PY - 2008/12/19/medline PY - 2008/10/16/entrez SP - 1104 EP - 11 JF - Acta radiologica (Stockholm, Sweden : 1987) JO - Acta Radiol VL - 49 IS - 10 N2 - BACKGROUND: When a palpable breast mass is detected, a biopsy is usually performed even if the mass reveals probably benign morphologic features on imaging, as there is relatively little data reporting the outcome of such breast masses. PURPOSE: To determine the negative predictive value for sonographic evaluation of palpable breast masses with probably benign morphology, and to assess whether follow-up may be an acceptable alternative to immediate biopsy. MATERIAL AND METHODS: Of the 1399 sonograms of palpable masses from January 2004 to September 2005, there were 397 patients with masses of probably benign morphology. This study included 274 of these patients (age range 12-64 years, mean age 34 years) with 312 palpable masses that were pathologically confirmed by fine-needle aspiration (n=7), ultrasound (US)-guided core needle biopsy (n=180), or surgical biopsy (n=125). The false-negative rate, negative predictive value (NPV), and 95% confidence interval (CI) were calculated using the SPSS statistical software package for Windows, version 12.0. A P value <0.05 was considered statistically significant. RESULTS: Of the 312 masses, there were 310 benign lesions and two malignancies, resulting in a false-negative rate of 0.6% (NPV 99.4%, P value=0.0432, 95% CI 0.0-1.5%). CONCLUSION: The negative predictive value of sonography for palpable breast masses with probably benign morphology is high (99.4%). Therefore, short-term imaging follow-up can be an acceptable alternative to immediate biopsy, similar to the management of nonpalpable probably benign lesions (BI-RADS category 3). SN - 1600-0455 UR - https://www.unboundmedicine.com/medline/citation/18855166/Palpable_breast_masses_with_probably_benign_morphology_at_sonography:_can_biopsy_be_deferred L2 - https://journals.sagepub.com/doi/10.1080/02841850802438504?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -