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Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome.
Australas J Dermatol. 2008 Nov; 49(4):223-5.AJ

Abstract

A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy. On questioning, a history of diarrhoea, taste disturbance and weight loss was found. The onset of these changes coincided with the administration of thyroxine prescribed for a benign multinodular goitre. Hormonal investigations showed no abnormality and no underlying malignancy was found. Investigation of the diarrhoea showed a protein-losing enteropathy with generalized intestinal polyposis and non-specific histology. A diagnosis of Cronkhite-Canada syndrome was made. Treatment with prednisone and nutritional support has been partially effective.

Authors+Show Affiliations

School of Medicine, James Cook University, Cairns, Queensland, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

18855786

Citation

Ho, Vincent, et al. "Hyperpigmentation, Nail Dystrophy and Alopecia With Generalised Intestinal Polyposis: Cronkhite-Canada Syndrome." The Australasian Journal of Dermatology, vol. 49, no. 4, 2008, pp. 223-5.
Ho V, Banney L, Falhammar H. Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome. Australas J Dermatol. 2008;49(4):223-5.
Ho, V., Banney, L., & Falhammar, H. (2008). Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome. The Australasian Journal of Dermatology, 49(4), 223-5. https://doi.org/10.1111/j.1440-0960.2008.00474.x
Ho V, Banney L, Falhammar H. Hyperpigmentation, Nail Dystrophy and Alopecia With Generalised Intestinal Polyposis: Cronkhite-Canada Syndrome. Australas J Dermatol. 2008;49(4):223-5. PubMed PMID: 18855786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hyperpigmentation, nail dystrophy and alopecia with generalised intestinal polyposis: Cronkhite-Canada syndrome. AU - Ho,Vincent, AU - Banney,Leith, AU - Falhammar,Henrik, PY - 2008/10/16/pubmed PY - 2009/2/26/medline PY - 2008/10/16/entrez SP - 223 EP - 5 JF - The Australasian journal of dermatology JO - Australas. J. Dermatol. VL - 49 IS - 4 N2 - A 62-year-old Malaysian woman presented with a constellation of skin signs including alopecia, hyperpigmentation and nail dystrophy. On questioning, a history of diarrhoea, taste disturbance and weight loss was found. The onset of these changes coincided with the administration of thyroxine prescribed for a benign multinodular goitre. Hormonal investigations showed no abnormality and no underlying malignancy was found. Investigation of the diarrhoea showed a protein-losing enteropathy with generalized intestinal polyposis and non-specific histology. A diagnosis of Cronkhite-Canada syndrome was made. Treatment with prednisone and nutritional support has been partially effective. SN - 1440-0960 UR - https://www.unboundmedicine.com/medline/citation/18855786/Hyperpigmentation_nail_dystrophy_and_alopecia_with_generalised_intestinal_polyposis:_Cronkhite_Canada_syndrome_ L2 - https://doi.org/10.1111/j.1440-0960.2008.00474.x DB - PRIME DP - Unbound Medicine ER -