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Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin.
Addict Biol. 2009 Jan; 14(1):73-83.AB

Abstract

There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence that may precipitate relapse in alcoholics, e.g. craving and disturbances in sleep and mood. This proof-of-concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non-treatment-seeking sample of cue-reactive, alcohol-dependent individuals. Subjects were 33 paid volunteers with current Diagnostic and Statistical Manual of Mental Disorders-IV alcohol dependence and a strength of craving rating 1 SD or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1 week and then participated in a within-subjects trial where each was exposed to standardized sets of pleasant, neutral and unpleasant visual stimuli followed by alcohol or water cues. Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving. Gabapentin was also associated with significant improvement on several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue-reactivity studies as proof-of-concept screens for potential antirelapse drugs.

Authors+Show Affiliations

The Pearson Center for Alcoholism and Addiction Research and Laboratory of Clinical Psychopharmacology, The Scripps Research Institute, USA. mason@scripps.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase III
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18855801

Citation

Mason, Barbara J., et al. "Proof-of-concept Human Laboratory Study for Protracted Abstinence in Alcohol Dependence: Effects of Gabapentin." Addiction Biology, vol. 14, no. 1, 2009, pp. 73-83.
Mason BJ, Light JM, Williams LD, et al. Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. Addict Biol. 2009;14(1):73-83.
Mason, B. J., Light, J. M., Williams, L. D., & Drobes, D. J. (2009). Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. Addiction Biology, 14(1), 73-83. https://doi.org/10.1111/j.1369-1600.2008.00133.x
Mason BJ, et al. Proof-of-concept Human Laboratory Study for Protracted Abstinence in Alcohol Dependence: Effects of Gabapentin. Addict Biol. 2009;14(1):73-83. PubMed PMID: 18855801.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Proof-of-concept human laboratory study for protracted abstinence in alcohol dependence: effects of gabapentin. AU - Mason,Barbara J, AU - Light,John M, AU - Williams,Lauren D, AU - Drobes,David J, Y1 - 2008/10/09/ PY - 2008/10/16/pubmed PY - 2009/4/25/medline PY - 2008/10/16/entrez SP - 73 EP - 83 JF - Addiction biology JO - Addict Biol VL - 14 IS - 1 N2 - There is a need for safe medications that can effectively support recovery by treating symptoms of protracted abstinence that may precipitate relapse in alcoholics, e.g. craving and disturbances in sleep and mood. This proof-of-concept study reports on the effectiveness of gabapentin 1200 mg for attenuating these symptoms in a non-treatment-seeking sample of cue-reactive, alcohol-dependent individuals. Subjects were 33 paid volunteers with current Diagnostic and Statistical Manual of Mental Disorders-IV alcohol dependence and a strength of craving rating 1 SD or greater for alcohol than water cues. Subjects were randomly assigned to gabapentin or placebo for 1 week and then participated in a within-subjects trial where each was exposed to standardized sets of pleasant, neutral and unpleasant visual stimuli followed by alcohol or water cues. Gabapentin was associated with significantly greater reductions than placebo on several measures of subjective craving for alcohol as well as for affectively evoked craving. Gabapentin was also associated with significant improvement on several measures of sleep quality. Side effects were minimal, and gabapentin effects were not found to resemble any major classes of abused drugs. Results suggest that gabapentin may be effective for treating the protracted abstinence phase in alcohol dependence and that a randomized clinical trial would be an appropriate next step. The study also suggests the value of cue-reactivity studies as proof-of-concept screens for potential antirelapse drugs. SN - 1369-1600 UR - https://www.unboundmedicine.com/medline/citation/18855801/Proof_of_concept_human_laboratory_study_for_protracted_abstinence_in_alcohol_dependence:_effects_of_gabapentin_ L2 - https://doi.org/10.1111/j.1369-1600.2008.00133.x DB - PRIME DP - Unbound Medicine ER -