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Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins.
Addiction. 2008 Aug; 103(8):1391-8.A

Abstract

AIMS

To compute the common and specific genetic and environmental contributions to nicotine dependence (ND) alcohol dependence (AD) and cannabis dependence (CD).

DESIGN

Twin model.

PARTICIPANTS

Data from 1874 monozygotic and 1498 dizygotic twin pair members of the Vietnam Era Twin Registry were obtained via telephone administration of a structured psychiatric interview in 1992.

MEASUREMENTS

Data to derive life-time diagnoses of DSM-III-R ND, AD and CD were obtained via telephone administration of the Diagnostic Interview Schedule.

FINDINGS

The best-fitting model allowed for additive genetic contributions and unique environmental influences that were common to all three phenotypes. Risks for ND and AD were also due to genetic and unique environmental influences specific to each drug. A specific shared environmental factor contributed to CD.

CONCLUSIONS

These results suggest that the life-time co-occurrence of ND, AD and CD is due to common and specific genetic factors as well as unique environmental influences, and vulnerability for CD is also due to shared environmental factors that do not contribute to ND and AD. The majority of genetic variance is shared across drugs and the majority of unique environmental influences are drug-specific in these middle-aged men. Because differences between models allowing for specific genetic versus shared environment were small, we are most confident in concluding that there are specific familial contributions-either additive genetic or shared environment-to CD.

Authors+Show Affiliations

Research Service, St Louis Veterans Affairs Medical Center (VAMC), St Louis, MO 63106, USA. hong.xian@va.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Twin Study

Language

eng

PubMed ID

18855830

Citation

Xian, Hong, et al. "Genetic and Environmental Contributions to Nicotine, Alcohol and Cannabis Dependence in Male Twins." Addiction (Abingdon, England), vol. 103, no. 8, 2008, pp. 1391-8.
Xian H, Scherrer JF, Grant JD, et al. Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. Addiction. 2008;103(8):1391-8.
Xian, H., Scherrer, J. F., Grant, J. D., Eisen, S. A., True, W. R., Jacob, T., & Bucholz, K. K. (2008). Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. Addiction (Abingdon, England), 103(8), 1391-8. https://doi.org/10.1111/j.1360-0443.2008.02243.x
Xian H, et al. Genetic and Environmental Contributions to Nicotine, Alcohol and Cannabis Dependence in Male Twins. Addiction. 2008;103(8):1391-8. PubMed PMID: 18855830.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic and environmental contributions to nicotine, alcohol and cannabis dependence in male twins. AU - Xian,Hong, AU - Scherrer,Jeffrey F, AU - Grant,Julia D, AU - Eisen,Seth A, AU - True,William R, AU - Jacob,Theodore, AU - Bucholz,Kathleen K, PY - 2008/10/16/pubmed PY - 2009/6/13/medline PY - 2008/10/16/entrez SP - 1391 EP - 8 JF - Addiction (Abingdon, England) JO - Addiction VL - 103 IS - 8 N2 - AIMS: To compute the common and specific genetic and environmental contributions to nicotine dependence (ND) alcohol dependence (AD) and cannabis dependence (CD). DESIGN: Twin model. PARTICIPANTS: Data from 1874 monozygotic and 1498 dizygotic twin pair members of the Vietnam Era Twin Registry were obtained via telephone administration of a structured psychiatric interview in 1992. MEASUREMENTS: Data to derive life-time diagnoses of DSM-III-R ND, AD and CD were obtained via telephone administration of the Diagnostic Interview Schedule. FINDINGS: The best-fitting model allowed for additive genetic contributions and unique environmental influences that were common to all three phenotypes. Risks for ND and AD were also due to genetic and unique environmental influences specific to each drug. A specific shared environmental factor contributed to CD. CONCLUSIONS: These results suggest that the life-time co-occurrence of ND, AD and CD is due to common and specific genetic factors as well as unique environmental influences, and vulnerability for CD is also due to shared environmental factors that do not contribute to ND and AD. The majority of genetic variance is shared across drugs and the majority of unique environmental influences are drug-specific in these middle-aged men. Because differences between models allowing for specific genetic versus shared environment were small, we are most confident in concluding that there are specific familial contributions-either additive genetic or shared environment-to CD. SN - 0965-2140 UR - https://www.unboundmedicine.com/medline/citation/18855830/Genetic_and_environmental_contributions_to_nicotine_alcohol_and_cannabis_dependence_in_male_twins_ DB - PRIME DP - Unbound Medicine ER -