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Action of beer and its ingredients on gastric acid secretion and release of gastrin in humans.
Gastroenterology. 1991 Oct; 101(4):935-42.G

Abstract

The intragastric action of beer and its known ingredients before and after fermentation on gastric acid secretion and release of gastrin was studied in healthy humans. None of 11 tested ingredients of fermented beer (2 x 500 mL, pH 5.5, given either alone or in combination) or hop extract had any significant effect. Finished beer (6 weeks old) and new beer were potent stimuli of acid output, causing 93% and 76% of the incremental maximal acid output in response to pentagastrin (6 micrograms/kg SC), respectively. Before the addition of yeast, preproducts of beer were considerably less potent. Thus, first and finished wort caused only a minor acid response which was 48% and 46% of maximal acid output. Foreign fermentation in first and finished wort is presumably the reason for the stimulatory action because glucose solutions in concentrations (11.5% wt/vol) seen in wort did not stimulate acid secretion. However, glucose solutions to which yeast was added, resulting in fermentation, were as potent stimuli of acid secretion as beer. Lyophilization of beer at pH 11.0 and dialysis (cutoff mol wt, 1000) removed the stimulatory substances. The plasma gastrin responses paralleled the gastric acid response to the different stimulants. It was concluded that (a) the addition of yeast to finished wort and the following alcoholic fermentation are the essential steps for the stimulatory action of beer on gastric acid secretion and release of gastrin; (b) carbohydrate metabolites with a molecular weight of less than 1000 are the acid-stimulatory agents in fermented beer; and (c) gastrin is the mediator of the stimulation of acid secretion because all substances that had a potent acid-stimulatory action also were potent stimuli of gastrin release.

Authors+Show Affiliations

Department of Medicine, University of Essen, Germany.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1889717

Citation

Singer, M V., et al. "Action of Beer and Its Ingredients On Gastric Acid Secretion and Release of Gastrin in Humans." Gastroenterology, vol. 101, no. 4, 1991, pp. 935-42.
Singer MV, Teyssen S, Eysselein VE. Action of beer and its ingredients on gastric acid secretion and release of gastrin in humans. Gastroenterology. 1991;101(4):935-42.
Singer, M. V., Teyssen, S., & Eysselein, V. E. (1991). Action of beer and its ingredients on gastric acid secretion and release of gastrin in humans. Gastroenterology, 101(4), 935-42.
Singer MV, Teyssen S, Eysselein VE. Action of Beer and Its Ingredients On Gastric Acid Secretion and Release of Gastrin in Humans. Gastroenterology. 1991;101(4):935-42. PubMed PMID: 1889717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Action of beer and its ingredients on gastric acid secretion and release of gastrin in humans. AU - Singer,M V, AU - Teyssen,S, AU - Eysselein,V E, PY - 1991/10/1/pubmed PY - 1991/10/1/medline PY - 1991/10/1/entrez SP - 935 EP - 42 JF - Gastroenterology JO - Gastroenterology VL - 101 IS - 4 N2 - The intragastric action of beer and its known ingredients before and after fermentation on gastric acid secretion and release of gastrin was studied in healthy humans. None of 11 tested ingredients of fermented beer (2 x 500 mL, pH 5.5, given either alone or in combination) or hop extract had any significant effect. Finished beer (6 weeks old) and new beer were potent stimuli of acid output, causing 93% and 76% of the incremental maximal acid output in response to pentagastrin (6 micrograms/kg SC), respectively. Before the addition of yeast, preproducts of beer were considerably less potent. Thus, first and finished wort caused only a minor acid response which was 48% and 46% of maximal acid output. Foreign fermentation in first and finished wort is presumably the reason for the stimulatory action because glucose solutions in concentrations (11.5% wt/vol) seen in wort did not stimulate acid secretion. However, glucose solutions to which yeast was added, resulting in fermentation, were as potent stimuli of acid secretion as beer. Lyophilization of beer at pH 11.0 and dialysis (cutoff mol wt, 1000) removed the stimulatory substances. The plasma gastrin responses paralleled the gastric acid response to the different stimulants. It was concluded that (a) the addition of yeast to finished wort and the following alcoholic fermentation are the essential steps for the stimulatory action of beer on gastric acid secretion and release of gastrin; (b) carbohydrate metabolites with a molecular weight of less than 1000 are the acid-stimulatory agents in fermented beer; and (c) gastrin is the mediator of the stimulation of acid secretion because all substances that had a potent acid-stimulatory action also were potent stimuli of gastrin release. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/1889717/Action_of_beer_and_its_ingredients_on_gastric_acid_secretion_and_release_of_gastrin_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0016-5085(91)90718-Z DB - PRIME DP - Unbound Medicine ER -