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Treatment of 5-fluorouracil-induced stomatitis by allopurinol mouthwashes.
Oncology. 1991; 48(4):282-4.O

Abstract

5-Fluorouracil (5-FU) is the most commonly used drug in carcinomas of the gastrointestinal tract. However, stomatitis is one of the limiting side effects. In the present study, 18 patients with gastrointestinal cancer who experienced 5-FU-induced stomatitis in previous cycles used allopurinol mouthwashes in subsequent courses of 5-FU (500 mg of 5-FU/m2/day, i.v., over 2 h for 5 days). The degree of stomatitis diminished in 15 patients (83.3%). Allopurinol mouthwash could be used as a simple and effective method for the reduction of 5-FU-induced oral toxicity. However, further controlled trials are required.

Authors+Show Affiliations

Radiation Oncology Unit, Faculty of Medicine, Suez Canal University Ismailia, Port Said, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1891169

Citation

Elzawawy, A. "Treatment of 5-fluorouracil-induced Stomatitis By Allopurinol Mouthwashes." Oncology, vol. 48, no. 4, 1991, pp. 282-4.
Elzawawy A. Treatment of 5-fluorouracil-induced stomatitis by allopurinol mouthwashes. Oncology. 1991;48(4):282-4.
Elzawawy, A. (1991). Treatment of 5-fluorouracil-induced stomatitis by allopurinol mouthwashes. Oncology, 48(4), 282-4.
Elzawawy A. Treatment of 5-fluorouracil-induced Stomatitis By Allopurinol Mouthwashes. Oncology. 1991;48(4):282-4. PubMed PMID: 1891169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of 5-fluorouracil-induced stomatitis by allopurinol mouthwashes. A1 - Elzawawy,A, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 282 EP - 4 JF - Oncology JO - Oncology VL - 48 IS - 4 N2 - 5-Fluorouracil (5-FU) is the most commonly used drug in carcinomas of the gastrointestinal tract. However, stomatitis is one of the limiting side effects. In the present study, 18 patients with gastrointestinal cancer who experienced 5-FU-induced stomatitis in previous cycles used allopurinol mouthwashes in subsequent courses of 5-FU (500 mg of 5-FU/m2/day, i.v., over 2 h for 5 days). The degree of stomatitis diminished in 15 patients (83.3%). Allopurinol mouthwash could be used as a simple and effective method for the reduction of 5-FU-induced oral toxicity. However, further controlled trials are required. SN - 0030-2414 UR - https://www.unboundmedicine.com/medline/citation/1891169/Treatment_of_5_fluorouracil_induced_stomatitis_by_allopurinol_mouthwashes_ L2 - https://www.karger.com?DOI=10.1159/000226943 DB - PRIME DP - Unbound Medicine ER -