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Risk factors for dementia in the epidemiological study of Munguialde County (Basque Country-Spain).
BMC Neurol 2008; 8:39BN

Abstract

BACKGROUND

Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular risk factors (hypertension, diabetes mellitus and hypercholesterolemia) and depression has been evaluated.The incidence of dementia and risk factors has not been fully investigated in Spain. The aim of this study was to identify the risk factors for dementia, Alzheimer's disease (AD) and vascular dementia (VD) in elderly people in Munguialde County (Spain).

METHODS

A two phase, door-to-door populational study was performed. Demographic variables and the presence of vascular risk factors and depression were recorded. The MMSE, the DSM-IV and the conventional criteria for AD and VD were used in the evaluation. The odds ratio for each risk factor was calculated by logistic regression analysis.

RESULTS

1756 healthy subjects and 175 patients with dementia participated in the study. Of these, 133 had AD, 15 VD and the remainder other dementias. The risk factors for dementia and AD were female sex (OR = 1.67 and 1.97, respectively); age (OR = 1.14 and 1.15); stroke (OR = 7.84 and 3); and depression (OR = 53.08 and 3.19). Stroke was the only risk factor for VD (OR = 119).

CONCLUSION

Greater age, female sex, stroke and depression increase the risk of suffering dementia, AD and VD. The relationship between depression, vascular risk factors and dementia has clear public health implications. Prevention and early treatment of vascular risk factors and depression may have an important impact in lowering the risk of dementia and could modify the natural history of the disease.

Authors+Show Affiliations

Department of Neurology, Hospital de Cruces, Baracaldo, Vizcaya, Spain. mfernandezm@meditex.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18922150

Citation

Fernández Martínez, Manuel, et al. "Risk Factors for Dementia in the Epidemiological Study of Munguialde County (Basque Country-Spain)." BMC Neurology, vol. 8, 2008, p. 39.
Fernández Martínez M, Castro Flores J, Pérez de Las Heras S, et al. Risk factors for dementia in the epidemiological study of Munguialde County (Basque Country-Spain). BMC Neurol. 2008;8:39.
Fernández Martínez, M., Castro Flores, J., Pérez de Las Heras, S., Mandaluniz Lekumberri, A., Gordejuela Menocal, M., & Zarranz Imirizaldu, J. J. (2008). Risk factors for dementia in the epidemiological study of Munguialde County (Basque Country-Spain). BMC Neurology, 8, p. 39. doi:10.1186/1471-2377-8-39.
Fernández Martínez M, et al. Risk Factors for Dementia in the Epidemiological Study of Munguialde County (Basque Country-Spain). BMC Neurol. 2008 Oct 15;8:39. PubMed PMID: 18922150.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for dementia in the epidemiological study of Munguialde County (Basque Country-Spain). AU - Fernández Martínez,Manuel, AU - Castro Flores,Jessica, AU - Pérez de Las Heras,Susana, AU - Mandaluniz Lekumberri,Aitziber, AU - Gordejuela Menocal,María, AU - Zarranz Imirizaldu,Juan José, Y1 - 2008/10/15/ PY - 2008/03/19/received PY - 2008/10/15/accepted PY - 2008/10/17/pubmed PY - 2009/4/9/medline PY - 2008/10/17/entrez SP - 39 EP - 39 JF - BMC neurology JO - BMC Neurol VL - 8 N2 - BACKGROUND: Prevalence of degenerative dementias and dementias associated with cerebrovascular disease is increasing. Dementia is one of the most significant public health problem. In recent years, the role of vascular risk factors (hypertension, diabetes mellitus and hypercholesterolemia) and depression has been evaluated.The incidence of dementia and risk factors has not been fully investigated in Spain. The aim of this study was to identify the risk factors for dementia, Alzheimer's disease (AD) and vascular dementia (VD) in elderly people in Munguialde County (Spain). METHODS: A two phase, door-to-door populational study was performed. Demographic variables and the presence of vascular risk factors and depression were recorded. The MMSE, the DSM-IV and the conventional criteria for AD and VD were used in the evaluation. The odds ratio for each risk factor was calculated by logistic regression analysis. RESULTS: 1756 healthy subjects and 175 patients with dementia participated in the study. Of these, 133 had AD, 15 VD and the remainder other dementias. The risk factors for dementia and AD were female sex (OR = 1.67 and 1.97, respectively); age (OR = 1.14 and 1.15); stroke (OR = 7.84 and 3); and depression (OR = 53.08 and 3.19). Stroke was the only risk factor for VD (OR = 119). CONCLUSION: Greater age, female sex, stroke and depression increase the risk of suffering dementia, AD and VD. The relationship between depression, vascular risk factors and dementia has clear public health implications. Prevention and early treatment of vascular risk factors and depression may have an important impact in lowering the risk of dementia and could modify the natural history of the disease. SN - 1471-2377 UR - https://www.unboundmedicine.com/medline/citation/18922150/Risk_factors_for_dementia_in_the_epidemiological_study_of_Munguialde_County__Basque_Country_Spain__ L2 - https://bmcneurol.biomedcentral.com/articles/10.1186/1471-2377-8-39 DB - PRIME DP - Unbound Medicine ER -