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Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study.
Diabetes Res Clin Pract. 2008 Dec; 82(3):364-77.DR

Abstract

OBJECTIVE

Dyslipidaemia is present not only in diabetic but also in prediabetic subjects. The purpose of this study is to investigate the relationship between lipid and glucose levels in a large European population without a prior history of diabetes.

RESEARCH DESIGN AND METHODS

Data from the population-based studies of 8960 men and 10,516 women aged 35-74 years representing 15 cohorts in 8 European countries were jointly analyzed. Multivariate adjusted linear regression analyses with standardized coefficients (beta) were performed to estimate the relationship between lipid and plasma glucose.

RESULTS

In subjects without a prior history of diabetes, positive relationships were shown between fasting plasma glucose (FPG) and total cholesterol (TC) (beta=0.06 and 0.03, respectively for men and women, p<0.01), triglycerides (TG) (beta=0.14 and 0.12, p<0.001), non-high-density lipoprotein cholesterol (non-HDL-C) (beta=0.06 and 0.03, p<0.01) and TC to HDL ratio (beta=0.06 and 0.05, p<0.001) but a negative trend between FPG and HDL-C (beta=-0.02, p>0.05 in men and beta=-0.03, p<0.05 in women). The relationship between lipid and 2-h plasma glucose (2hPG) followed a similar pattern as that for FPG, except that TC was not increased and HDL-C was reduced in both sexes in subjects with impaired glucose tolerance (IGT).

CONCLUSIONS

For cardiovascular prevention, the different lipid patterns between impaired fasting glucose (IFG) and IGT may deserve further attention to evaluate the combined risks of dyslipidaemia and elevated glucose levels below the diagnostic threshold of diabetes.

Authors+Show Affiliations

Department of Public Health, University of Helsinki, Helsinki, Finland. lei.zhang@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18922596

Citation

Zhang, L, et al. "Blood Lipid Levels in Relation to Glucose Status in European Men and Women Without a Prior History of Diabetes: the DECODE Study." Diabetes Research and Clinical Practice, vol. 82, no. 3, 2008, pp. 364-77.
Zhang L, Qiao Q, Tuomilehto J, et al. Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study. Diabetes Res Clin Pract. 2008;82(3):364-77.
Zhang, L., Qiao, Q., Tuomilehto, J., Hammar, N., Alberti, K. G., Eliasson, M., Heine, R. J., Stehouwer, C. D., & Ruotolo, G. (2008). Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study. Diabetes Research and Clinical Practice, 82(3), 364-77. https://doi.org/10.1016/j.diabres.2008.08.022
Zhang L, et al. Blood Lipid Levels in Relation to Glucose Status in European Men and Women Without a Prior History of Diabetes: the DECODE Study. Diabetes Res Clin Pract. 2008;82(3):364-77. PubMed PMID: 18922596.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood lipid levels in relation to glucose status in European men and women without a prior history of diabetes: the DECODE Study. AU - Zhang,L, AU - Qiao,Q, AU - Tuomilehto,J, AU - Hammar,N, AU - Alberti,K G M M, AU - Eliasson,M, AU - Heine,R J, AU - Stehouwer,C D A, AU - Ruotolo,G, AU - ,, Y1 - 2008/10/14/ PY - 2007/11/01/received PY - 2008/08/22/revised PY - 2008/08/26/accepted PY - 2008/10/17/pubmed PY - 2009/1/9/medline PY - 2008/10/17/entrez SP - 364 EP - 77 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 82 IS - 3 N2 - OBJECTIVE: Dyslipidaemia is present not only in diabetic but also in prediabetic subjects. The purpose of this study is to investigate the relationship between lipid and glucose levels in a large European population without a prior history of diabetes. RESEARCH DESIGN AND METHODS: Data from the population-based studies of 8960 men and 10,516 women aged 35-74 years representing 15 cohorts in 8 European countries were jointly analyzed. Multivariate adjusted linear regression analyses with standardized coefficients (beta) were performed to estimate the relationship between lipid and plasma glucose. RESULTS: In subjects without a prior history of diabetes, positive relationships were shown between fasting plasma glucose (FPG) and total cholesterol (TC) (beta=0.06 and 0.03, respectively for men and women, p<0.01), triglycerides (TG) (beta=0.14 and 0.12, p<0.001), non-high-density lipoprotein cholesterol (non-HDL-C) (beta=0.06 and 0.03, p<0.01) and TC to HDL ratio (beta=0.06 and 0.05, p<0.001) but a negative trend between FPG and HDL-C (beta=-0.02, p>0.05 in men and beta=-0.03, p<0.05 in women). The relationship between lipid and 2-h plasma glucose (2hPG) followed a similar pattern as that for FPG, except that TC was not increased and HDL-C was reduced in both sexes in subjects with impaired glucose tolerance (IGT). CONCLUSIONS: For cardiovascular prevention, the different lipid patterns between impaired fasting glucose (IFG) and IGT may deserve further attention to evaluate the combined risks of dyslipidaemia and elevated glucose levels below the diagnostic threshold of diabetes. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18922596/Blood_lipid_levels_in_relation_to_glucose_status_in_European_men_and_women_without_a_prior_history_of_diabetes:_the_DECODE_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00397-5 DB - PRIME DP - Unbound Medicine ER -