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Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation.
J Pharm Biomed Anal. 2008 Dec 01; 48(4):1112-9.JP

Abstract

Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO(2)) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 degrees C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 degrees C/17.2 MPa, drug release behavior obeyed a n-power law (n=0.54).

Authors+Show Affiliations

Clean Materials Technology Group, Department of Chemistry, University College London, Christopher Ingold Building, 20 Gordon Street, London WC1H 0AJ, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18922658

Citation

Gong, Kenan, et al. "Characterization and Drug Release Investigation of Amorphous Drug-hydroxypropyl Methylcellulose Composites Made Via Supercritical Carbon Dioxide Assisted Impregnation." Journal of Pharmaceutical and Biomedical Analysis, vol. 48, no. 4, 2008, pp. 1112-9.
Gong K, Rehman IU, Darr JA. Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation. J Pharm Biomed Anal. 2008;48(4):1112-9.
Gong, K., Rehman, I. U., & Darr, J. A. (2008). Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation. Journal of Pharmaceutical and Biomedical Analysis, 48(4), 1112-9. https://doi.org/10.1016/j.jpba.2008.08.031
Gong K, Rehman IU, Darr JA. Characterization and Drug Release Investigation of Amorphous Drug-hydroxypropyl Methylcellulose Composites Made Via Supercritical Carbon Dioxide Assisted Impregnation. J Pharm Biomed Anal. 2008 Dec 1;48(4):1112-9. PubMed PMID: 18922658.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization and drug release investigation of amorphous drug-hydroxypropyl methylcellulose composites made via supercritical carbon dioxide assisted impregnation. AU - Gong,Kenan, AU - Rehman,Ihtesham U, AU - Darr,Jawwad A, Y1 - 2008/09/07/ PY - 2008/07/09/received PY - 2008/08/15/revised PY - 2008/08/22/accepted PY - 2008/10/17/pubmed PY - 2009/4/1/medline PY - 2008/10/17/entrez SP - 1112 EP - 9 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 48 IS - 4 N2 - Hydroxypropylmethyl cellulose (HPMC)-indomethacin (4:1, w/w) drug composites (DCs) were prepared via supercritical carbon dioxide (sc-CO(2)) assisted impregnation. The effect of processing temperature (at fixed pressures) on the physical and other properties of the resulting HPMC-indomethacin DCs was investigated using a range of analytical techniques, including differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, Raman spectroscopy, and powder X-ray diffraction (XRD) methods. The data suggest that for a 4:1 (w/w) HPMC-indomethacin ratio prepared at 130 degrees C (17.2 MPa), the indomethacin exists entirely in an amorphous dispersion within the polymer matrix. The primary interaction between HPMC and indomethacin appears to be hydrogen bonding between the carboxylic acid carbonyl group of indomethacin and hydroxyl group of HPMC. The initial (first 15 min) and overall drug release behavior within a 5h timeframe for the HPMC-indomethacin DCs, was analyzed. For the HPMC-indomethacin drug composite processed at 130 degrees C/17.2 MPa, drug release behavior obeyed a n-power law (n=0.54). SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/18922658/Characterization_and_drug_release_investigation_of_amorphous_drug_hydroxypropyl_methylcellulose_composites_made_via_supercritical_carbon_dioxide_assisted_impregnation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(08)00452-4 DB - PRIME DP - Unbound Medicine ER -